F. Wang

New metabolic alterations and predictive marker pipecolic acid in sera for esophageal squamous cell carcinoma

This study identifies 12 serum metabolites associated with esophageal squamous cell carcinoma and highlights pipecolic acid as a predictive biomarker for tumorigenesis.

Transmembrane Kinases are essential for plant development

Analysis of multiple tmk mutants reveals key roles of TMKs in plant development, including organogenesis, leaf size, fertility, and selfing population defects.

Airway bacterial and fungal microbiome in chronic obstructive pulmonary disease

This study characterizes the airway bacterial and fungal microbiome in COPD patients and healthy controls, finding altered microbial diversity and interactions associated with disease severity.

Cryo-EM study on the homo-oligomeric ring formation of yeast TRiC/CCT subunits reveals TRiC ring assembly mechanism

This study uses cryo-EM to reveal the mechanism of TRiC/CCT ring assembly in yeast, showing subunit-specific roles and ATP-driven assembly dynamics.

A phosphorylation of RIPK3 kinase initiates an intracellular apoptotic pathway that promotes corpus luteum regression

This study shows that RIPK3 phosphorylation at S165/T166 switches its function from necroptosis to apoptosis, driving corpus luteum regression via PGF2-induced apoptosis.

Expanded Asgard archaea shed new light on the origin of eukaryotes and support a 2-domain tree of life

This study identifies five new Asgard archaeal phyla, expands the Asgard superphylum, and supports a 2-domain tree of life by showing Tyrarchaeota as a deeper branching lineage than Heimdallarchaeota.

Molecular mechanism underlying the non-essentiality of Bub1 for the fidelity of chromosome segregation in human cells

This study shows Bub1 and the CENP-U complex redundantly recruit Plk1 to kinetochores, ensuring accurate chromosome segregation, and suggests potential therapeutic targets for cancer cells with Bub1 or CENP-U mutations.

Identification of anti-severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) oxysterol derivatives in vitro

This study identifies oxysterol derivatives with anti-SARS-CoV-2 activity, showing that Oxy210 and Oxy232 inhibit viral replication by disrupting double membrane vesicles.

Hedgehog pathway inhibitors significantly reduce the formation of heterotopic ossification in a direct trauma/burn mouse model

This study shows that Hedgehog pathway inhibitors reduce heterotopic ossification in a trauma/burn mouse model by inhibiting osteoblast differentiation and systemic inflammation.

Spatial drivers and pre-cancer populations collaborate with the microenvironment in untreated and chemo-resistant pancreatic cancer

This paper uses spatial single-cell omics to analyze PDAC tumors and microenvironment, identifying key populations and interactions that may inform treatment strategies.

Fatal COVID-19 and non-COVID-19 Acute Respiratory Distress Syndrome is Associated with Incomplete Alveolar Type 1 Epithelial Cell Differentiation from the Transitional State Without Fibrosis

The paper shows that in fatal ARDS, alveolar type 1 cells do not fully differentiate from transitional cells without fibrosis, leading to persistent barrier permeability and respiratory failure.

Effects of climatic warming on spring phenology in subtropical trees: process-based modelling with experiments designed for model development

This study develops process-based tree phenology models for subtropical trees using experimental data, showing advanced spring phenology under warming with species-specific responses.

Enhanced reproductive thermotolerance is associated with increased accumulation of flavonols in pollen of the tomato high-pigment 2 mutant.

This study shows that increased flavonol accumulation in tomato hp2 mutant pollen enhances thermotolerance and reproductive success under heat stress.

Casein Kinase 1G2 Suppresses Necroptosis-Promoted Testis Aging by Inhibiting Receptor-Interacting Kinase 3

This study shows that CSNK1G2 inhibits RIP3-mediated necroptosis, reducing testis aging in mice and conserved in humans.

Sequential ER stress and inflammatory responses are induced by SARS-CoV-2 ORF3 through ERphagy

This study identifies SARS-CoV-2 ORF3 as an inducer of ERphagy, leading to ER stress and inflammatory responses, which may be targeted for COVID-19 treatment.

Potent SARS-CoV-2 neutralizing antibodies selected from a human antibody library constructed decades ago

The paper identifies potent SARS-CoV-2 neutralizing antibodies from a pre-pandemic human antibody library, showing high somatic hypermutation and specific binding to the spike protein.

Molecular and morphological analyses clarify species delimitation and reveal a new Betula species in section Costatae

The paper uses molecular and morphological data to clarify species boundaries in Betula section Costatae, identifying a new species, Betula buggsii, within the group.

IFN-{lambda}4 may contribute to HCV persistence by increasing ER stress and enhancing IRF1 signaling

This study investigates the association between IFNL4 genetic variants and HCV-related cirrhosis and HCC risk, finding protective effects against cirrhosis and increased HCC risk in specific populations.

Leukemia stemness and co-occurring mutations drive resistance to IDH inhibitors in acute myeloid leukemia

The paper identifies leukemia stemness and co-occurring mutations as drivers of resistance to IDH inhibitors in AML through genomic analyses of treated patients.

Multiple glacial refugia across northern and southern China and unexpected patterns of spatial genetic diversity in Betula albosinensis: a widespread temperate deciduous tree species

The paper tests hypotheses about genetic diversity patterns in Betula albosinensis, finding support for the central-marginal hypothesis and the role of multiple glacial refugia.

Bathyarchaeota Occurence in Shallow Marine Methane-rich Sediments (Saco Do Mamangua, Rio de Janeiro, Brazil)

The paper investigates the spatial and vertical distribution of microbial communities in methane-rich sediments of Saco do Mamangua, Brazil, highlighting the prevalence of Bathyarchaeota.

SARS-CoV-2 Spike protein promotes hyper-inflammatory response that can be ameliorated by Spike-antagonistic peptide and FDA-approved ER stress and MAP kinase inhibitors in vitro

This study shows that SARS-CoV-2 spike protein induces inflammation and epithelial damage, which can be reduced by an antagonistic peptide and FDA-approved drugs.

Altering the solubility of the antibiotic candidate Nisin - a computational study

This study uses molecular dynamics simulations to investigate how mutations affect nisin solubility and evaluates force fields' ability to model solubility of uncommon amino acids.

Single-cell immune landscape of human recurrent spontaneous abortion

This study uses single-cell RNA-sequencing to analyze decidual and peripheral leukocytes in normal and RSA pregnancies, revealing immune dysregulation in RSA.

Inferring MHC interacting SARS-CoV-2 epitopes recognized by TCRs towards designing T cell-based vaccines

This study infers SARS-CoV-2 epitopes recognized by TCRs through structural modeling and designs a T cell-based vaccine using immunoinformatics tools.

Assembly of a double-stranded RNA synthesizing complex: RNA-DEPENDENT RNA POLYMERASE 2 docks with NUCLEAR RNA POLYMERASE IV at the clamp domain

The paper identifies how RDR2 binds to the clamp domain of Pol IV to facilitate dsRNA synthesis for siRNA production in plants.

Celastrol directly inhibits PFKM to induce weight loss and leptin sensitization

This study identifies PFKM as a direct target of celastrol, showing that its inhibition promotes weight loss and leptin sensitivity through AMPK/ACC signaling.

Single-cell Characterization of Acute Myeloid Leukemia and its Microenvironment Following PD-1 Blockade Based Therapy

This study analyzes single-cell RNA and TCR profiles from AML patients before and after PD-1 blockade therapy to identify factors influencing response and resistance.

Targeting uncoupling of copy number and gene expression in cancers

The paper analyzes multiomics data to show that uncoupling of copy number and gene expression (UCNE) in cancer is associated with oncogenic signaling and immune suppression, and identifies potential therapeutic targets.

Suppression of MDA5-mediated antiviral immune responses by NSP8 of SARS-CoV-2

This study identifies NSP8 as a SARS-CoV-2 protein that suppresses MDA5-mediated antiviral immune responses by inhibiting type I IFN signaling.