J. Chen

Coordinated molecular and ecological adaptations underlie a highly successful parasitoid

This study identifies molecular and ecological adaptations in the parasitoid Trichopria drosophilae that enhance its success in parasitizing Drosophila hosts.

A Dimerization-dependent Allosteric Activation for Receptor-like Kinase in Plants

The paper shows that FERONIA (FER) activates its homologs through dimerization-dependent allosteric activation, with ROS enhancing dimerization and impacting plant responses like ABA-mediated stomatal movement.

TaNF-Y-PRC2 orchestrates temporal control of starch and protein synthesis in wheat

This study identifies the TaNF-Y-PRC2 complex as a regulator of starch and protein synthesis in wheat endosperm, revealing its role in epigenetic control through histone modification and gene repression.

One million years of solitude: the rapid evolution of de novo protein structure and complex

This study examines the rapid structural evolution of de novo genes in rice over 1 million years, finding faster changes in disordered regions and structured elements compared to gene duplicates.

Horizontal transfer and recombination fuel Ty4 retrotransposon evolution in Saccharomyces.

The paper investigates HTT and recombination in Saccharomyces Ty4 retrotransposons, finding multiple HTT events and novel clades formed through recombination.

Senolytics enhance longevity in Caenorhabditis elegans by altering betaine metabolism

This study identifies betaine metabolism as a key factor in aging in C. elegans and shows that senolytics extend lifespan by increasing betaine levels and enhancing autophagy and antioxidant capacity.

Distinct roles of H3K27me3 and H3K36me3 in vernalization response, maintenance and resetting in winter wheat

This study identifies distinct roles of H3K27me3 and H3K36me3 in vernalization response, maintenance, and resetting in winter wheat by analyzing transcriptome and chromatin dynamics.

Comprehensive Multi-Omic Analysis Reveals Distinct Molecular Features in Early and Advanced Stages of Hepatocellular Carcinoma

This study uses multi-omic analyses to identify molecular features and biomarkers in early and advanced hepatocellular carcinoma stages.

Inhibition of O-GlcNAc transferase activates type I interferon-dependent antitumor immunity by bridging cGAS-STING pathway

This study shows that inhibiting OGT activates type I interferon-dependent antitumor immunity by enhancing the cGAS-STING pathway through genomic instability.

Bosutinib stimulates macrophage survival, phagocytosis and intracellular killing of bacteria

This paper shows bosutinib enhances macrophage phagocytosis and bacterial killing, reducing infection in mice.

Battery-Free Optoelectronic Patch for Photodynamic and Light Therapies in Treating Bacteria-Infected Wounds

This paper introduces a battery-free optoelectronic patch for photodynamic and light therapies to treat bacterial infections, showing reduced bacterial load and enhanced tissue regeneration in animal models.

Amyloid-motif-dependent tau self-assembly is modulated by isoform sequence context

This study shows that tau aggregation can be reduced by modifying sequences near the PGGG β-turn motif, while maintaining microtubule binding, offering therapeutic insights for neurodegenerative diseases.

INHBA/Activin A promotes tumor growth and induces resistance to anti-PD-L1 therapy by suppressing IFN-γ signaling

This study shows that INHBA/activin A suppresses IFN-γ signaling, leading to resistance to anti-PD-L1 therapy and promoting tumor growth.

Lithocholic acid targets TULP3 to activate sirtuins and AMPK to retard ageing

This study identifies LCA's mechanism of action through TULP3-sirtuin-v-ATPase-AMPK pathway to activate AMPK and extend lifespan in model organisms.

Transposition, duplication, and divergence of the telomerase RNA underlies the Mimulus telomere evolution

The paper identifies transposition, duplication, and divergence of the telomerase RNA as the mechanism driving telomere sequence evolution in Mimulus species.

The intrinsically disordered tail of ESCO1 binds DNA in a charge-dependent manner

This study shows ESCO1's intrinsically disordered tail binds DNA via electrostatic interactions, but its catalytic activity is independent of direct DNA binding.

Armillaria korhonenii, the sixteenth biological species of Armillaria from China

The paper describes a new species of Armillaria, Armillaria korhonenii, based on phylogenetic, morphological, and mating test evidence, identifying it as the sixteenth biological species in China.

Plasmacytoid dendritic cells (pDCs) display surface but not membrane-bound IgE across a broad range of total serum IgE levels

This study shows that plasmacytoid dendritic cells (pDCs) have surface-bound IgE but not membrane-bound IgE, despite similar IgE removal by omalizumab in basophils.

Filter-aided expansion proteomics

The paper introduces FAXP, a method combining hydrogel expansion and mass spectrometry for high-resolution proteomics of FFPE tissues, showing improved resolution and efficiency over existing methods.

Phylogeny-metabolism dual-directed single-cell genomics for dissecting and mining ecosystem function

This paper introduces FISH-scRACS-Seq, a method to identify and sequence single cells with specific metabolic functions, revealing a new cyclohexane-degrading enzyme system in marine bacteria.

RAG-17: A Novel siRNA Conjugate Demonstrating Efficacy in Late-Stage Treatment of SOD1G93A ALS mice

This study introduces RD-12500, an siRNA conjugate that effectively reduces SOD1 levels and delays disease progression in late-stage SOD1G93A ALS mice.

Modulation of Biophysical Properties of Nucleocapsid Protein in the Mutant Spectrum of SARS-CoV-2

The paper examines how mutations in SARS-CoV-2 nucleocapsid protein's intrinsically disordered regions affect its biophysical properties across different variants.

AvrSr27 is a zinc-bound effector with a modular structure important for immune recognition

The paper reports the crystal structure of AvrSr27, a Pgt effector, revealing its modular zinc-bound fold and its role in immune recognition by Sr27.

CEP44 is required for maintaining centriole duplication and spindle integrity

This study identifies CEP44's role in preventing centriole overduplication and maintaining spindle integrity, linking it to breast carcinoma prognosis.

Hammerhead-type FXR agonists induce an eRNA FincoR that ameliorates nonalcoholic steatohepatitis in mice

This study identifies a novel FXR-induced eRNA, FincoR, which mediates the therapeutic effects of hammerhead-type FXR agonists in NASH mice.

Evolutionarily new genes in humans with disease phenotypes reveal functional enrichment patterns shaped by adaptive innovation and sexual selection.

This study identifies evolutionarily new genes in humans with disease phenotypes, showing their enrichment in male reproductive diseases and adaptive traits like brain size and color vision.

Leukemia in Sprague-Dawley Rats Exposed Long-term from Prenatal Life to Glyphosate and Glyphosate-Based Herbicides

This study shows that glyphosate and glyphosate-based herbicides caused increased leukemia incidence in rats at exposure levels within the EU ADI and NOAEL.

UDP-glucosyltransferase 71C4 regulates seed development by redistributing phenylpropanoid metabolism in cotton

This study identifies UGT71C4's role in regulating seed development and yield traits in cotton by modulating phenylpropanoid metabolism, lignin, and flavonoid pathways.

Non-canonical hepatic androgen receptor mediates glucagon sensitivity in female mice through the PGC1α/ERRα/mitochondria axis

This study identifies hepatic androgen receptor as a mediator of glucagon sensitivity in female mice, revealing its role in glucose and lipid metabolism via the PGC1α/ERRα/mitochondria axis.

Berberine impairs spermatogenesis in mice by modulating ornithine metabolism via gut microbiota regulation

This study shows berberine reduces sperm count and testosterone in mice by altering gut microbiota, specifically reducing Muribaculaceae, and affecting ornithine metabolism.