J. Chen

Estrogen prevents age-dependent beige adipogenesis failure through NAMPT-controlled ER stress pathway

This study shows estrogen prevents age-related failure in beige adipogenesis by controlling ER stress via NAMPT, improving energy expenditure and glucose tolerance in mice.

Logic Gate Activated Lysosome Targeting DNA Nanodevice for Controlled Proteins Degradation

This paper develops a logic-gate activated lysosome targeting DNA nanodevice for controlled protein degradation and modulates T cell-mediated antitumor immunity.

Exposure to titanium dioxide nanoparticles accelerates abnormal fat deposition through the mediation of the ROS via the AGE-RAGE signaling pathway in mice

This study shows that titanium dioxide nanoparticles induce fat deposition in mice by increasing ROS and activating the AGE-RAGE pathway, with NAC as a potential therapeutic.

Accurate Simulation of Coupling between Protein Secondary Structure and Liquid-Liquid Phase Separation

This paper introduces a hybrid resolution protein model (HyRes) to accurately simulate the coupling between protein secondary structure and liquid-liquid phase separation in intrinsically disordered proteins.

Ecological drift during colonization drives within- and between-host heterogeneity in animal symbiont populations

The paper shows ecological drift drives microbiome heterogeneity in squash bugs, both between and within hosts, without requiring host-mediated selection.

Global and local adaptation to aridity in a desert plant Gymnocarpos przewalskii

This study identifies genes involved in global and local adaptation to aridity in Gymnocarpos przewalskii, finding limited overlap between the two processes.

Pleistocene glaciation advances the younger temporal dimension of species diversification in a major biodiversity hotspot

The paper uses genomic and eco-morphological analysis to reveal recent diversification in the Stellera chamaejasme L. complex, driven by Pleistocene glaciation and biotic factors.

Heart-on-a-chip model of immune-induced cardiac dysfunction reveals the involvement of free mitochondrial DNA and therapeutic effects of endothelial exosomes

This paper develops a heart-on-a-chip model to study immune-induced cardiac dysfunction, identifying mitochondrial DNA as a key factor and showing therapeutic potential of endothelial exosomes.

Mitochondrial DNA released by senescent cells triggers immunosuppression in cancer

This study shows that mtDNA released by senescent cells triggers immunosuppression via PMN-MDSCs, and inhibiting this pathway enhances therapy-induced senescence in cancer.

FAM210A mediates an inter-organelle crosstalk essential for protein synthesis and muscle growth in mouse

This study identifies FAM210A as a mediator of mitochondrial-ribosome crosstalk that supports protein synthesis and muscle growth in mice.

Plant TIR domains physically interact with EDS1 family proteins to propagate immune signalling.

The paper shows TIR domains interact with EDS1 family proteins and helper NLRs to propagate immune signaling in plants.

Comprehensive catalogs for microbial genes and metagenome-assembled genomes of the swine lower respiratory tract microbiome identify the relationship of microbial species with lung lesions

The paper constructs gene catalogs and metagenome-assembled genomes from the swine lower respiratory tract microbiome and identifies associations between microbial species and lung lesions.

miRNA-encoded regulatory peptides modulate cadmium tolerance and accumulation in rice

This study identifies miPEP156e, a miRNA-encoded peptide in rice, which enhances cadmium tolerance by modulating ROS and Cd transporter genes.

Cold temperature induces a TRPM8-independent calcium release from the endoplasmic reticulum in human platelets

This study shows cold temperature activates human platelets via TRPM8-dependent and -independent mechanisms, with TRPM8 involved in early activation and ER calcium release driving later responses.

Quantification of glutathione with high throughput live-cell imaging

This study quantifies glutathione dynamics in living cells using a reversible fluorescent probe, demonstrating its sensitivity and applicability in high-throughput imaging.

Intrarenal myeloid subsets associated with kidney injury are comparable in mice and patients with lupus nephritis

This study identifies conserved myeloid subsets and disease-associated gene expression changes in kidney injury across lupus mouse models and human patients with lupus nephritis.

Identification and Characterization of CtUGT3 as the Key Player of Astragalin Biosynthesis in Safflower

This study identifies CtUGT3 as the key UGT enzyme responsible for astragalin biosynthesis in safflower through metabolomics, transcriptome analysis, and biochemical experiments.

The principles of peptide selection by the transporter associated with antigen processing

The paper determines TAP structures with peptides to show how it selects peptides by length while allowing sequence diversity through terminal interactions.

Mechanically stimulated osteocytes maintain tumor dormancy in bone metastasis of non-small cell lung cancer by releasing small extracellular vesicles

This study shows that mechanically stimulated osteocytes release extracellular vesicles containing microRNAs that inhibit NSCLC cell proliferation and bone metastasis progression.

Quorum-sensing agr system of Staphylococcus aureus primes gene expression for protection from lethal oxidative stress

This study shows that the agr quorum-sensing system in Staphylococcus aureus primes the bacteria to resist oxidative stress by controlling reactive oxygen species, even when the system is not actively activated.

AGILE Platform: A Deep Learning-Powered Approach to Accelerate LNP Development for mRNA Delivery

AGILE uses deep learning and combinatorial chemistry to rapidly design and evaluate ionizable lipids for mRNA delivery, revealing cell-specific preferences for lipid structures.

Tumor-specific neutrophils originating from meninges promote glioblastoma

This study identifies tumor-specific neutrophils in glioblastoma that originate from meninges and contribute to immunosuppression, showing their role in tumor progression and poor prognosis.

The first complete mitochondrial genome of Sphaeniscus atilius (Walker, 1849) (Diptera: Tephritidae) and implications for the phylogenetic relationships of Tephritidae

This study characterizes the first complete mitochondrial genome of Sphaeniscus atilius and presents phylogenetic insights for Tephritidae family relationships.

Stimulator of interferon genes is required for Toll-Like Receptor-8 induced interferon response

This study shows that STING is required for TLR8-induced IFN production in human monocytes and reveals a new crosstalk mechanism between cytosolic and endosomal innate immune receptors.

Discovery and characterization of highly potent and selective covalent inhibitors of SARS-CoV-2 PLpro

This study identifies and characterizes two covalent PLpro inhibitors, HUP0109 and DX-027, as potential treatments for SARS-CoV-2.

Microsporidia dressing up: the spore polaroplast transport through the polar tube and transformation into the sporoplasm membrane

This study investigates the formation of the sporoplasm membrane during microsporidia spore germination, revealing that the polaroplast transforms into the sporoplasm membrane via the polar tube.

Pooled effector library screening in protoplasts rapidly identifies novel Avr genes

This paper develops a pooled effector library screening platform in plant protoplasts to identify Avr genes interacting with R genes, validating it by discovering known and novel Avr genes from wheat stem rust.

Colocalization of Protein and microRNA Markers Reveals Unique Extracellular Vesicle Sub-Populations for Early Cancer Detection

This study introduces NOBEL-SPA to analyze EV sub-populations by colocalizing protein and miRNA markers, identifying unique signatures for early breast cancer detection.

Serum from pregnant donors induces human beta cell proliferation and insulin secretion

This study shows that serum from pregnant donors can stimulate human beta cell proliferation and insulin secretion, suggesting potential for beta cell expansion.

Insight into the genetic diversity, resistance, and virulence of Listeria from the marine environment: reveal the risk of hypervirulent isolates

This study examines Listeria species in beach sand, identifying hypervirulent isolates and their potential role in human listeriosis.