P. Li

Gaq-PKD/PKCμ regulates the IkB transcription to limit the NF-kB mediated inflammatory response essential for early pregnancy

This study shows that Gaq-PKD/PKCμ regulates IκB transcription to limit NF-κB-mediated inflammation, essential for successful early pregnancy.

Combined Developmental Toxicity Of Cyhalofop-butyl And Quizalofop-p-ethyl On The Zebrafish (Danio rerio) Embryos

This study evaluates the combined developmental toxicity of cyhalofop-butyl and quizalofop-p-ethyl on zebrafish embryos, finding an antagonistic effect and altered gene expression related to apoptosis and cardiac development.

Nimbolide Targets RNF114 to Induce the Trapping of PARP1 and Poly-ADP-Ribosylation-Dependent DNA Repair Factors

This study identifies RNF114 as a key player in PARP1 trapping and shows that nimbolide blocks its degradation, enhancing PARP1 trapping and cytotoxicity in BRCA-deficient cancers.

Expanding adult tubular microvessels on stiff substrates with endothelial cells and pericytes from the same tissue

This study develops a culture model to expand adult tubular microvessels on stiff substrates using endothelial cells and pericytes from the same tissue, showing improved growth and morphology with a custom medium.

A Peronophythora litchii RXLR effector PlAvh202 enhances plant susceptibility by destabilizing host SAMS

This study identifies PlAvh202, an RXLR effector from Peronophythora litchii, which enhances plant susceptibility by destabilizing SAMS and suppressing ethylene production.

Doublecortin and JIP3 are neural-specific counteracting regulators of dynein-mediated retrograde trafficking

This study identifies DCX and JIP3 as neural-specific regulators that counteract each other in dynein-mediated retrograde trafficking by modulating dynein-microtubule binding and motor complex composition.

PcoB is a defense outer membrane protein that facilitates cellular uptake of copper

This study characterizes PcoB, an outer membrane protein that facilitates copper import, revealing its structure and function in Cu homeostasis and defense against metal stress.

Two Rac1 pools integrate the direction and coordination of collective cell migration

This study identifies two switchable Rac1 pools in Drosophila border cells that integrate direction and coordination during collective migration.

Transcriptomic analysis reveals hub genes and pathways in response to acetic acid stress in Kluyveromyces marxianus during high-temperature ethanol fermentation

This study identifies differentially expressed genes and pathways in Kluyveromyces marxianus under acetic acid stress during high-temperature ethanol fermentation, revealing effects on protein metabolism and ethanol production.

The energy landscape reshaped by strain-specific mutations underlies the long-range epistasis in NS1 evolution of influenza A virus

The paper investigates how strain-specific mutations in the NS1 protein of influenza A virus reshape the energy landscape, leading to long-range epistasis.

Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity

This study shows that ZBP1 and cGAS cooperate to detect mitochondrial DNA, leading to cardiotoxicity, and that blocking this interaction protects against heart damage.

Microparticle-delivered Cxcl9 prolongs Braf inhibitor efficacy in melanoma

The paper shows that delivering Cxcl9 via microparticles enhances the effectiveness of BRAF inhibitors in melanoma by reducing minimal residual disease relapse.

A Novel Y-Shaped, S-O-N-O-S-Bridged Crosslink between Three Residues C22, C44, and K61 Is a Redox Switch of the SARS-CoV-2 Main Protease

The paper identifies a novel Y-shaped crosslink in SARS-CoV-2 MPro that acts as a redox switch, regulating its catalytic activity and offering new targets for antiviral drug development.

Structural and biochemical insights into lipid transport by VPS13 proteins.

The paper presents the crystal structure of VPS13s adaptor binding domain complexed with a Pro-X-Pro peptide and shows that scramblases partner with bulk lipid transport proteins.

Inter-subunit coupling enables fast CO2-fixation by reductive carboxylases

This paper investigates the structural and dynamic mechanisms of CO2 fixation by ECRs, revealing inter-subunit coupling that enables fast catalytic activity.

Comprehensive dissection of immune microenvironment in the progression of early gastric cancer at spatial and single-cell resolution

This study uses spatial transcriptomics and single-cell RNA-seq to analyze immune microenvironment changes in gastric cancer progression, identifying immune cell dysregulation and key signaling pathways.

Gut Microbiome Contributes to Cold-climate Adaptation in Lizards

The paper investigates how gut microbiota contributes to cold-climate adaptation in two lizard species, finding species-specific differences in microbial composition and metabolic gene abundance.

Core Microbiota Drive the Prevalence of Extracellular Antibiotic Resistome in the Water Compartments

The paper identifies core bacterial taxa and mobile genetic elements associated with extracellular antibiotic resistance genes in water compartments.

Rare Monoclonal Antibody Discovery Based on Indirect Competitive Screening of Single Hapten-specific Rabbit Antibody Secreting Cell

This paper introduces a method to discover rare rabbit monoclonal antibodies against small molecules using an indirect competitive screening approach, resulting in a highly stable antibody with exceptional halophilic properties.

Assessment of chimeric antigen receptor T (CAR-T) cytotoxicity by droplet microfluidics in vitro

This study presents a droplet microfluidic assay to assess CAR-T cytotoxicity in vitro, enabling analysis of activity, expansion, and mechanism under varying conditions.

Geminivirus C4 proteins inhibit GA signaling via prevention of NbGAI degradation, to promote viral infection and symptom development in N. benthamiana

The N-Terminal Carbamate is Key to High Cellular and Antiviral Potency for Boceprevir-Based SARS-CoV-2 Main Protease Inhibitors

This paper identifies that a P4 N-terminal carbamate in boceprevir-based inhibitors is crucial for high antiviral potency against SARS-CoV-2.

The P3 O-Tert-Butyl-Threonine is Key to High Cellular and Antiviral Potency for Aldehyde-Based SARS-CoV-2 Main Protease Inhibitors

This study identifies O-tert-butyl-threonine at the P3 site as critical for enhancing cellular and antiviral potency of MPro inhibitors.

Overexpression of NDR1 Leads to Pathogen Resistance at Elevated Temperatures

The paper shows NDR1 overexpression enhances pathogen resistance at elevated temperatures by maintaining immune signaling during ETI.

IGF1 Signaling in Temporomandibular Joint Fibrocartilage Stem Cells Regulates Cartilage Growth and Homeostasis in Mice

This study shows that Igf1 deletion in TMJ fibrocartilage stem cells causes cartilage degeneration and worsens osteoarthritis in mice.

Mitochondrial dysfunction promotes alternative gasdermin D-mediated inflammatory cell death and susceptibility to infection

This study shows that mitochondrial dysfunction caused by Lrrk2G2019S promotes non-pyroptotic cell death via GSDMD and increases susceptibility to infection.

FOXP4 differentially controls cold-induced beige adipocyte differentiation and thermogenesis

This study identifies FOXP4 as a regulator of beige adipocyte differentiation and thermogenesis, showing it suppresses thermogenic potential in preadipocytes but enhances it in mature adipocytes.

A histone variant condenses flowering plant sperm via chromatin phase separation

This study identifies H2B.8 as a histone variant that mediates chromatin condensation in flowering plant sperm through phase separation, enabling nuclear compaction without transcriptional inhibition.

MicroRNA-27a-5p inhibits proliferation, migration and invasion and promotes apoptosis of Wilms tumor cell by targeting PBOV1

This study shows miR-27a-5p suppresses Wilms tumor by inducing apoptosis and inhibiting proliferation, migration, and invasion through targeting PBOV1.

Gastric cancer derived exosomes induce peritoneal mesothelial cell EMT through TGF-β1/Smads pathway to promote peritoneal metastasis

This study shows GC-derived exosomes induce EMT in peritoneal mesothelial cells via TGF-β1/Smads pathway, enhancing GC cell migration and adhesion.