Q. Yang

Collagen co-localised with macrovesicular steatosis for fibrosis progression in non-alcoholic fatty liver disease

This study quantifies steatosis and fibrosis progression in NAFLD models, finding that collagen co-localized with macrosteatosis better differentiates fibrosis stages.

Phage DNA polymerase prevents deleterious on-target damage and enhances precise CRISPR/Cas9 editing

This study identifies T4 DNA polymerase as a tool to enhance CRISPR/Cas9 editing precision by reducing on-target deletions and translocations while increasing insertion accuracy.

Atlas-Guided Discovery of Transcription Factors for T Cell Programming

The paper identifies transcription factors driving distinct CD8+ T cell states and shows their impact on tumor control and immunotherapy.

High-quality nuclear genome and mitogenome of Bipolaris sorokiniana strain LK93, a devastating pathogen causing wheat root rot

The paper sequences and assembles the nuclear and mitochondrial genomes of Bipolaris sorokiniana strain LK93 to improve understanding of its interaction with wheat.

A legacy role for DNA binding of Lon protects against genotoxic stress

The paper shows that Lon protease DNA binding protects bacteria and mitochondria from genotoxic stress by clearing bound proteins.

X-Chromosome Target Specificity Diverged Between Dosage Compensation Mechanisms of Two Closely Related Caenorhabditis Species

The paper compares X-chromosome dosage compensation mechanisms in C. briggsae and C. elegans, finding divergent DCC target specificity and binding modes.

Improved Neutralization of Omicron BA.4/5, BA.4.6, BA.2.75.2, BQ.1.1, and XBB.1 with Bivalent BA.4/5 Vaccine

This study compares the neutralizing antibody responses induced by monovalent and bivalent BA.4/5 vaccines against multiple Omicron sublineages in individuals over 55 years old, finding the bivalent vaccine elicits stronger neutralization.

Terminal differentiation of villus-tip enterocytes is governed by distinct members of Tgfβ superfamily

This study identifies distinct roles of Bmp2 and Tgfβ in driving specific enterocytic programs at different villus regions, with Bmp2 promoting terminal differentiation at the villus-tip.

Oral Feeding of Nanoplastics reduces Brain function of Mice by Inducing Intestinal IL-1β-producing Macrophages

This study shows that oral nanoplastic exposure in mice leads to gut macrophage activation and IL-1β production, which affects brain function by causing microglial activation and cognitive decline.

Biophysical and Structural Characterization of a Viral Genome Packaging Motor

This paper characterizes the biophysical properties and initial structure of λ terminase during DNA translocation, showing a pentameric complex with flexibility and ATP hydrolysis activity.

Regulation of phage lambda packaging motor-DNA interactions: Nucleotide independent and dependent gripping and friction

This study investigates phage lambda packaging motor-DNA interactions, revealing nucleotide-independent and -dependent gripping and friction mechanisms, and proposes a DNA end clamp function for TerS.

Exposure to BA.4/BA.5 Spike glycoprotein drives pan-Omicron neutralization in vaccine-experienced humans and mice

This study shows that exposure to BA.4/BA.5 spike glycoprotein enhances neutralizing antibody breadth against Omicron variants in vaccinated humans and mice.

Nucleobase adduct-containing metabolites are MR1 ligands that stimulate self-reactive MR1T cells

The paper identifies nucleobase adduct-containing metabolites as MR1 ligands that activate self-reactive MR1T cells, highlighting their role in detecting metabolic stress in cancer.

A microglia-CD4+ T cell partnership generates protective anti-tumor immunity to glioblastoma

This study identifies a microglia-CD4+ T cell interaction that enhances anti-glioblastoma immunity through IFN-gamma-mediated tumor surveillance and phagocytosis.

LC-MS/MS-PRM Quantification of IgG glycoforms using stable isotope labeled IgG1 Fc glycopeptide standard

The paper introduces a workflow for quantifying IgG glycoforms using stable isotope labeled standards and LC-MS/MS-PRM, achieving high sensitivity and precision.

Spatial mapping of human lung tissue reveals granuloma diversity and histopathological superstructure in tuberculosis

This study maps spatial immune cell composition in human TB lung tissue, revealing diverse non-necrotizing aggregates surrounding necrotizing granulomas.

An Evidence-based Cognitive Model of Uncertainty during Indoor Multi-level Human Wayfinding

This study develops a cognitive model of uncertainty in human wayfinding using empirical data, showing that uncertainty correlates with time since last helpful sign and that the model replicates human behavior better than pathing algorithms.

Novel leaf-root coordination driven by leaf water storage tissues in mangroves

This study identifies a unique leaf-root coordination mechanism in mangroves driven by leaf water storage tissues, distinct from non-mangrove plants.

ADOLESCENT EXPOSURE TO LOW-DOSE THC DISRUPTS ENERGY BALANCE AND ADIPOSE ORGAN HOMEOSTASIS IN ADULTHOOD

This study shows that adolescent exposure to low-dose THC leads to metabolic changes in adulthood, including reduced fat mass and adipose dysfunction.

Integration of microprism and microelectrode arrays enables simultaneous electrophysiology and two-photon imaging across all cortical layers

This paper introduces a device combining microelectrodes and microprisms for simultaneous electrophysiology and two-photon imaging across all cortical layers in mice.

Neutrophils reprograms the bone marrow to impair T-cell immunity during tuberculosis

This study shows that neutrophils in tuberculosis promote pathologic hematopoiesis by producing G-CSF, which impairs T-cell immunity through IFNAR1 signaling.

Single-shot Volumetric Chemical Imaging by Mid- Infrared Photothermal Fourier Light Field Microscopy

This paper introduces MIP-FLF microscopy to enable fast, volumetric infrared spectroscopic imaging of living cells and organisms, revealing lipid metabolism changes in drug-resistant pancreatic cancer cells.

Nanotopography modulates intracellular excitable systems through cytoskeleton actuation

The paper shows nanotopography is sensed directly by cytoskeletal networks, with implications for texture sensing and guidance cues in microenvironments.

Neutralization of Omicron sublineages and Deltacron SARS-CoV-2 by 3 doses of BNT162b2 vaccine or BA.1 infection

This study evaluates the neutralization of Omicron sublineages and Deltacron by BNT162b2 vaccine or BA.1 infection, finding BA.4/5 shows highest evasion.

Mitochondrial genome recovery by ATFS-1 is essential for development following starvation

This study shows that ATFS-1's mitochondrial localization, not its nuclear activity, is essential for mtDNA recovery and development after starvation in C. elegans.

Lipidomic profiling reveals concerted temporal patterns of functionally related lipids in Aedes aegypti females following blood feeding

This study identifies temporal lipidomic changes in Aedes aegypti mosquitoes post-blood meal, highlighting functional lipid patterns linked to reproduction.

Dendritic cell Piezo1 integrating mechanical stiffness and inflammatory signals directs the differentiation of TH1 and Treg cells in cancer

Wolbachia inhibits ovarian formation and increases blood avidity in female Aedes aegypti

This study shows Wolbachia wAlbB in Aedes aegypti inhibits ovarian formation and increases blood feeding in infertile females, with implications for Wolbachia release strategies and host evolution.

The senescence regulator S40 family members from Caragana intermedia and Arabidopsis thaliana inhibit leaf senescence via promoting cytokinins synthesis

This study identifies CiS40-11 and its orthologs AtS40-5 and AtS40-6 as regulators of leaf senescence that promote cytokinin synthesis by inhibiting MYB2 expression.

Neutralization of Omicron BA.1, BA.2, and BA.3 SARS-CoV-2 by 3 doses of BNT162b2 vaccine

This study assesses the neutralization of Omicron sublineages BA.1, BA.2, and BA.3 by BNT162b2 vaccine sera, finding reduced neutralization compared to the original SARS-CoV-2 strain.