S. Basu

Physics of Self-Assembly and Morpho-Topological Changes of Klebsiella Pneumoniae in Desiccating Sessile Droplets

This study examines how Klebsiella Pneumoniae self-assembles and changes morphology during droplet desiccation, revealing physical mechanisms affecting bacterial survival and pathogenesis.

CK2 signaling from TOLLIP-dependent perinuclear endosomes is an essential feature of KRAS and NRAS mutant cancers

This study identifies TOLLIP as a critical adaptor for CK2 signaling from perinuclear endosomes in KRAS and NRAS mutant cancers, showing its role in tumor proliferation and progression.

3'UTR-dependent dynamic changes in TP53 mRNA localization regulate p53 tumor suppressor activity

This study shows that 3'UTR sequences of TP53 mRNA regulate its localization and activity by modulating CK2 phosphorylation and AMPK2/HuR dynamics.

3'UTR-directed, kinase proximal mRNA decay inhibits C/EBPβ phosphorylation/activation to suppress senescence in tumor cells

This study identifies a mechanism where 3'UTR-directed mRNA decay inhibits C/EBPβ activation, suppressing senescence in tumor cells and promoting tumor progression.

Metagenomes of Red Sea subpopulations challenge the use of morphology and marker genes to assess Trichodesmium diversity

The paper assesses Trichodesmium diversity in the Red Sea using metagenomes and hetR gene phylotyping, finding that morphology and marker genes may not reliably reflect genetic diversity.

Computational study on Strontium ion modified Fibronectin-Hydroxyapatite interaction

This paper uses molecular dynamics simulations to study how Sr2+ doping affects fibronectin adsorption on HA surfaces, finding enhanced adhesion and structural flexibility but no impact on RGD motif availability.

Capturing a crucial 'disorder-to-order transition' at the heart of the coronavirus molecular pathology - triggered by highly persistent, interchangeable salt-bridges

The paper investigates the disorder-to-order transition in the SARS-CoV-2 Spike protein upon Furin binding, highlighting salt-bridge networks and their role in proteolytic cleavage efficiency.

Two Liberibacter Effectors Combine to Suppress Critical Innate Immune Defenses and Facilitate Huanglongbing Pathogenesis in Citrus

The paper investigates two CLas effectors, P235 and Effector 3, showing they suppress citrus innate immune responses and contribute to HLB pathogenesis by inhibiting immune proteins and inducing cell death.

Legume plant defenses and nutrients mediate indirect interactions between soil rhizobia and chewing herbivores

This study shows that chewing herbivores interact with soil rhizobia through plant-mediated pathways, affecting both herbivore feeding and rhizobial symbiosis.

PTPN14, a modifier of HHT, protects SMAD4 from ubiquitination and turnover to potentiate BMP9 signaling in endothelial cells.

This study identifies PTPN14 as a stabilizer of SMAD4, enhancing BMP9 signaling in endothelial cells and suggesting potential drug targets for HHT.

Protein reservoirs of seeds are composites of amyloid and amyloid-like structures facilitating sustained release during germination and seedling growth

This study identifies amyloid and amyloid-like structures in plant seed storage protein bodies (SSPB) and demonstrates their role in controlling germination and seedling growth.

Identification of SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of the nsp14 RNA Cap Methyltransferase

This study identifies four small molecule inhibitors of SARS-CoV-2 nsp14 RNA cap methyltransferase, with three showing synergy with remdesivir in antiviral assays.

Mycobacterium tuberculosis DosS binds H2S through its Fe3+ heme iron to regulate the Dos dormancy regulon

This study shows Mycobacterium tuberculosis uses its DosS sensor kinase to detect H2S via Fe3+ heme binding, activating the dormancy regulon.

Vapor mediation as a tool to control micro-nano scale dendritic crystallization and preferential bacterial distribution in drying respiratory droplets

This paper controls dendritic crystallization and bacterial distribution in drying respiratory droplets using vapor-mediated interactions to manipulate flow dynamics and solute transfer.

Discovery and mechanism of action of small molecule inhibitors of ceramidases

The paper discovers small molecule inhibitors of alkaline ceramidase 3 using fluorescent substrates and characterizes their mechanism of action.

An automated platform for structural analysis of membrane proteins through serial crystallography

This paper introduces an automated platform for structural analysis of membrane proteins using serial crystallography, enabling high-throughput ligand discovery and structural determination.

Spatiotemporal evaporating droplet dynamics on fomites enhances long term bacterial pathogenesis

This study shows that evaporation-induced bacterial patterns on fomites enhance Salmonella Typhimurium virulence through hyper-proliferation in macrophages and sustained pathogenicity in mice.

Selective abrogation of S6K2 maps lipid homeostasis as a survival vulnerability in MAPKi-resistant NRASmut melanoma

This study identifies S6K2 as a vulnerability in MAPK inhibitor-resistant NRAS-mutant melanoma, showing its abrogation disrupts lipid homeostasis and triggers cell death.

Identifying SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of Nsp14/nsp10 Exoribonuclease

This study identifies patulin and aurintricarboxylic acid as inhibitors of SARS-CoV-2 nsp14 exoribonuclease, showing antiviral activity in cell culture.

Plant responses to multiple antagonists are mediated by order of attack and phytohormone crosstalk

This study shows that plant responses to multiple antagonists depend on attack order and phytohormone interactions, with some interactions being antagonistic and others synergistic.

Predators affect a plant virus through direct and trait-mediated indirect effects on vectors

The paper shows predators affect plant virus transmission through both direct consumption of aphids and indirect effects on aphid behavior and movement.

Electric field mediated fibronectin hydroxyapatite interaction: A molecular insight

This study uses molecular dynamics simulations to investigate how electric fields affect fibronectin adsorption on hydroxyapatite surfaces, revealing changes in protein structure and interactions.

Structure of TFIIH/Rad4-Rad23-Rad33 in damaged DNA opening in Nucleotide Excision Repair

The paper presents a cryo-EM structure of an NER initiation complex involving Rad4-Rad23-Rad33 and TFIIH bound to a DNA lesion, revealing DNA unwinding and translocation mechanisms.

Role of extracellular mycobacteria in blood-retinal barrier invasion in a zebrafish model of ocular TB

This study examines how extracellular and intracellular mycobacteria invade the blood-retinal barrier in a zebrafish model of ocular TB, showing different disease progression outcomes based on invasion mode.

Inhibition of Extracellular Vesicle-Associated MMP2 Abrogates Intercellular Transfer of Hepatic miR-122 to Tissue Macrophages and Curtails Liver Inflammation

The paper shows that inhibiting MMP2 on extracellular vesicles reduces miR-122 transfer to macrophages, thereby decreasing liver inflammation.

De novo synthesis of phosphatidylcholine is essential for the promastigote but not amastigote stage in Leishmania major

This study shows that de novo phosphatidylcholine synthesis via CEPT is essential for promastigote survival but not required for amastigote virulence or replication.

Orchard management and landscape context mediate the floral microbiome of pear

This study examines how orchard management and landscape context influence bacterial and fungal communities in pear flowers, revealing distinct effects on diversity and distribution of microbial taxa.

Spatiotemporal Control of Pathway Sensors and Cross-Pathway Feedback Regulate a Cell Differentiation MAPK Pathway in Yeast

The paper shows that temporal and spatial regulation of pathway sensors and cross-pathway feedback control the fMAPK pathway in yeast.

Lipid Droplets Promote Phase Separation of Ago2 to Accelerate Dicer1 Loss and Decelerate miRNA Activity in Lipid Exposed Hepatic Cells

The paper shows lipid droplets promote Ago2 phase separation, reduce Dicer1 levels, and decrease miR-122 activity in hepatic cells under lipotoxic stress.

Synergistic CDK control pathways maintain cell size homeostasis

The paper shows that inhibitory phosphorylation of CDK and PP2A synergistically regulate cell size homeostasis, and DNA concentration reduces CDK activity in diploid cells.