proteomics

Distinct core minor pilin complexes prime specialized type IV filaments in cyanobacteria

This study identifies two distinct core minor pilin complexes in cyanobacteria that prime specialized Type IV filaments for natural competence and motility.

RAStoERK: a reference interaction atlas for insights into signaling and disease

The paper creates a comprehensive reference map of the RAS/RAF/MEK/ERK pathway interactomes and their mutation-driven rewiring, revealing new interactions and disease links.

Beyond the Billion: Dose-Response Immunophenotyping and Machine Learning Classification of Live versus Heat-Inactivated Gram-Positive Probiotic Strains in Human Peripheral Blood Mononuclear Cells

This study challenges assumptions about probiotic efficacy by showing heat-treated strains can match live strains in immunological activity at higher doses, using flow cytometry and machine learning to classify probiotic strains.

Postsynaptic TAK1-GluN2B axis supports hippocampal synaptic integrity and cognitive function during aging

This study identifies a postsynaptic TAK1-GluN2B signaling axis that maintains synaptic integrity and cognitive function, with reduced TAK1 levels contributing to age-related hippocampal decline.

Targeting IGF2BP1 Creates a Mitotic Vulnerability in Colorectal Carcinoma

This study identifies IGF2BP1 as a regulator of mitotic integrity in CRC, showing that its inhibition creates a therapeutic vulnerability that synergizes with paclitaxel.

Accelerated discovery and optimization of a potent andselective MMP12 inhibitor with the machine learningplatform CAMOLE-1

This paper describes the development of CAMOLE-1, a machine learning platform for designing potent and selective MMP12 peptide inhibitors, achieving results in about one year with 270 synthesized peptides.

HEPLISAV-B Breaks Immune Tolerance and Induces HBV Control via CD4 T Cell-Dependent Mechanisms in a Chronic Hepatitis B Mouse Model

HEPLISAV-B vaccine breaks HBV immune tolerance in a mouse model, inducing HBsAg clearance and anti-HBs immunity through CD4 T cell-dependent mechanisms.

SARS-CoV-2 Main Protease Inhibition Through Dimerization Promotion by Peptidomimetic Inhibitors and Disruption by Ebselen

This study examines how different inhibitors affect the dimerization of SARS-CoV-2 main protease, revealing distinct mechanisms of action between peptidomimetics and ebselen.

Gingipain-containing products from Porphyromonas gingivalis promote epithelial CCL20 signaling and γδ T-cell accumulation in COPD-like airways

This paper shows that Porphyromonas gingivalis gingipain products induce CCL20 signaling and γδ T-cell accumulation in COPD-like airways via PAR-2 activation.

Protein Aggregation Capture for Top-down Proteomics

This paper introduces a magnetic bead-based sample preparation method for top-down proteomics to improve sensitivity and reduce sample loss during protein aggregation capture.

ROR2 drives right ventricular heart failure via disruption of proteostasis

This study identifies ROR2 as a driver of right ventricular failure by disrupting proteostasis, showing that modulating ROR2 can rescue structural and functional deficits in cardiomyocytes.

Pantoea ananatis-triggered systemic resistance requires root sensing through the LORE receptor kinase in Arabidopsis

This study shows that Pantoea ananatis triggers systemic resistance in Arabidopsis through root sensing via the LORE receptor kinase, using HAAs and 3-OH-C10 as MAMPs.

E2 displacement of CIP2A from TOPBP1 activates the DNA damage response during papillomavirus life cycles

This paper shows E2 activates the DNA damage response by displacing CIP2A from TOPBP1, promoting viral replication and cell proliferation through ATM activation and ATR inhibition.

Early mitophagy defects and impaired mitochondrial energy metabolism drive target organ damage progression: lessons from the Fabry heart

This study identifies mitochondrial dysfunction and impaired mitophagy as key drivers of cardiac damage in Fabry disease and shows that L-arginine supplementation can prevent cardiac abnormalities.

Spatiotemporal proteomics reveals dynamic antagonistic gradients shaping signalling waves

The paper uses a microfluidics and proteomics approach to study dynamic protein gradients in mouse embryos, revealing antagonistic ligand-receptor patterns that regulate Wnt oscillations and somite formation.

Non-canonical proteoforms of the human fusiform gyrus in Alzheimers disease

The paper identifies non-canonical proteins encoded by non-coding ORFs in Alzheimer's disease, finding 67 differentially expressed proteins in the fusiform gyrus.

Erythrocyte extravasation drives ferroptosis and inflammatory amplification in eccentric contraction-induced skeletal muscle injury via the heme-HO-1-iron axis

This study investigates how erythrocyte extravasation contributes to skeletal muscle injury via the heme-HO-1-iron axis, linking it to ferroptosis and inflammation.

Developmental and molecular features shaping broad and synergistic actions of human autoantibodies targeting interferon-α

This study tracks the development of human autoantibodies against interferons over time, revealing their maturation, specificity, and synergistic effects in blocking IFN signaling.

Effects of panitumumab on the proteome of treated EGFRvIII glioblastoma cells and on their extracellular vesicles

This study examines how panitumumab affects the proteome of EGFRvIII glioblastoma cells and their extracellular vesicles, showing reduced EGFRvIII on EVs and changes in extracellular matrix proteins.

AltORF-encoded microprotein recruits primary-ORF-encoded dehydrogenase to cell poles upon heat shock

The paper identifies an altORF-encoded microprotein, GndA, that facilitates stress-dependent relocalization of its primary ORF partner, Gnd, in E. coli during heat shock.

Synovial fluid glycosaminoglycans signature involved 3-O-sulfated heparan sulfate modulated by TGF-β pathway in OA

This study identifies 3-O-sulfated heparan sulfate in OA synovial fluid and shows its regulation by the TGF-β pathway in fibroblastic-like synoviocytes.

Functional Convergence of Genetically Diverse B-Cell Receptors in Simian-HIV Infected Rhesus Macaques

The paper investigates whether genetically diverse B-cell receptor responses in simian-HIV infected macaques converge functionally, finding that functional convergence does not require genetic convergence.

TMEM55B regulates lysosomal acidification and ER-lysosome calcium signaling to promote lipolysis

This study identifies TMEM55B as a regulator of lysosomal acidification and ER-lysosome calcium signaling, which promotes lipolysis and cholesterol metabolism.

High-light adaptation via ferredoxin-mediated tuning of the photosynthesis–photoprotection trade-off

Overexpression of Fd1 in tobacco plants adjusts the photosynthesis/photoprotection trade-off to enhance high-light adaptation.

Matched Plasma and Tissue Proteomics Reveal the Selective Nature of Circulating Biomarkers of Human Aging

This study identifies that plasma proteins selectively reflect tissue-specific aging processes in muscle and ovary, revealing context-dependent age-related changes.

Alpha-synuclein and neuromelanin converge to promote Parkinsons disease pathology

This study identifies a bidirectional pathogenic relationship between alpha-synuclein and neuromelanin in Parkinson's disease, showing they promote each other's accumulation and neuronal loss.

Calcium signaling recruits Rab27a and the exocyst complex to promote small extracellular vesicle release in skeletal muscle cells

Distinct patterns of skeletal muscle wasting and mitochondrial changes following hypoxia and inflammation: associations with physiological phenotype

This study examines how hypoxia and inflammation affect skeletal muscle mitochondrial function and protein turnover in different muscle types, finding muscle-specific responses and physiological variability.

Functional Validation of Known BEST1 Variants Using a Robust Halide-Sensitive YFP Quenching Assay

The paper develops a halide-sensitive YFP quenching assay to functionally validate BEST1 variants and distinguish loss-of-function from gain-of-function mutations.

Understanding cognitive function in post-COVID-19 condition with fatigue: an interdisciplinary multimodal investigation

This study investigates cognitive symptoms in post-COVID-19 condition with fatigue, finding subtle neurobiological changes not captured by standard assessments.