proteomics

Stage-specific proteomic signatures of synaptopathy in Alzheimers disease

The paper identifies stage-specific synaptic proteomic signatures in Alzheimer's disease and links them to plasma proteins associated with disease progression and cognitive decline.

Extracellular GPX3 drives insulin receptor expression in adipose tissue independent of its peroxidase activity

This study identifies GPX3 as a paracrine mediator of adipose tissue insulin sensitivity through a GPX3-SP1-InsR signaling axis, independent of its peroxidase activity.

Programmable antigen-presenting scaffolds expand rare tumor-antigen-specific T cells from peripheral blood

This paper introduces APC-ms, a platform that expands rare tumor-antigen-specific T cells from peripheral blood, achieving higher enrichment and functional properties compared to conventional methods.

Impaired astrocytic Cx43 syncytial network in lateral habenula affects synaptic connectivity and drives adolescent stress-induced depression

This study identifies impaired astrocytic Cx43 syncytial networks in the lateral habenula as a driver of adolescent stress-induced depression through disrupted synaptic connectivity and neuronal function.

A Pore-Forming Toxin Monalysin Contributes to Infection-Induced Suppression of Defecation in Female Drosophila

This study identifies Monalysin, a pore-forming toxin from Pseudomonas entomophila, as a factor that suppresses defecation in infected Drosophila females.

Hepatitis C virus NS5A is not an effective antagonist of the canonical PKR-eIF2α pathway

This study shows that HCV NS5A does not inhibit the PKR-eIF2 pathway, contradicting previous claims and supporting that HCV replicates despite active PKR response.

Multi-omics analyses reveal environmentally adaptive cell-state remodeling during human iPSC biomanufacturing

The paper shows that biomanufacturing conditions alter molecular states in hiPSCs without losing pluripotency, linking these changes to developmental programs.

Exploring noise in TCR specificity data through supervised learning

This paper introduces a supervised learning denoising method to identify low-quality labels in TCR specificity data, improving model reliability by filtering noisy examples.

Genetically distinct neurodegenerative proteinopathies engage overlapping proteostasis components

The paper identifies shared proteostasis components across genetically distinct neurodegenerative proteinopathies and highlights key candidates for functional testing.

Comparative genomics and structure-informed analysis identify a putative tandem receptor-binding module in Pseudomonas phage UF_RH1

Coupling microalgal bioremediation of recirculating aquaculture effluents with photobiological hydrogen production

This study integrates microalgal bioremediation of aquaculture effluents with hydrogen production using Chlamydomonas reinhardtii, achieving nutrient removal, bioenergy generation, and high-quality biomass.

Autophagosome-tethering compounds selectively lower mutant ataxin-3 in preclinical models of spinocerebellar ataxia type 3

Small-molecule autophagosome-tethering compounds selectively lower mutant ataxin-3 through an LC3- and autophagy-dependent mechanism and improve disease-related phenotypes in preclinical models of SCA3.

Distinct iron metabolism regulation during cachexia progression in murine models of intestinal and pancreatic cancer

This study compares iron metabolism regulation in two murine cancer models with cachexia, finding distinct patterns linked to cancer type rather than cachexia severity.

Proteomic signatures of sublethal deltamethrin exposure in the European earwig

This study identifies proteomic changes in European earwig females exposed to sublethal deltamethrin, revealing molecular stress without detectable phenotypic effects.

DNA polymerase kappa supports repair-associated DNA synthesis and genome maintenance in postmitotic neurons

This study identifies DNA polymerase kappa (POLK) as essential for DNA repair and genome maintenance in postmitotic neurons, showing its role in preventing neurodegeneration and aging-related stress.

A Neuronally Active Bacterial Siderophore Manipulates Host Behavior and Longevity

This study identifies bacterial enterobactin as a non-canonical neurotransmitter that modulates host behavior and aging via mitochondrial function and redox state.

Subpopulations of Pseudomonas aeruginosa inflict distinct tissue damage during infection

This study identifies distinct subpopulations of Pseudomonas aeruginosa that use different virulence factors to cause tissue damage during infection.

MXRA8-dependent chikungunya virus infection in PDGFRα+ mesenchymal cells increases vascular permeability and facilitates hematogenous spread

This study shows that MXRA8-dependent infection of PDGFRα+ mesenchymal cells by CHIKV increases vascular permeability, enabling hematogenous spread and joint swelling.

Engineered Chimeric Proteins Functionally Replace ALS-causing Endogenous FUS and TDP-43 to Improve Neuronal Health

The paper engineers chimeric proteins to replace ALS-causing FUS and TDP-43, improving neuronal health by reducing aggregation and restoring nuclear functions.

mzQC: a versatile way to communicate quality information for biological mass spectrometry

The paper introduces mzQC, a standard for representing quality control metrics in mass spectrometry, enabling interoperable and machine-readable QC reporting.

Mutational fitness landscapes of diverse human influenza H1N1 neuraminidases

This study quantifies the replication fitness effects of mutations in diverse H1N1 influenza neuraminidases, revealing strain-dependent effects and epistasis patterns.

Photo-downregulation of SIRT4 mitigates aging in mice by enhancing H3K9ac via fatty acid metabolism

This study shows that red light exposure reduces SIRT4 in aged mice, enhancing H3K9ac via fatty acid metabolism and mitigating cellular aging.

The SET1/COMPASS subunit RBBP5 orchestrates epigenetic control of global proteostasis and the 12h oscillator to safeguard metabolic and cellular homeostasis

This study identifies RBBP5 as an essential epigenetic regulator of the 12h oscillator and proteostasis, linking it to metabolic and cellular homeostasis in mammals.

Proteome modulation by opposite inotropic drugs in human engineered cardiac tissue revealed by topology-driven cross-modal integration

This study integrates proteomics and functional data using topological analysis to reveal how opposite inotropic drugs affect engineered cardiac tissue.

Phosphoproteomics profiling of the monocytes uncovers the mechanosensory pathways regulating monocytes responses to pathologic level of shear stress

This study identifies mechanosensory pathways in monocytes exposed to pathological shear stress, revealing PKC and Piezo1 as key regulators of monocyte phenotype and function in calcific aortic valve disease.

The actin-binding protein drebrin interacts with the respiratory syncytial virus matrix protein and promotes virus particle release.

This study identifies drebrin and TM9SF2 as host factors that regulate RSV release by promoting membrane scission during viral budding.

Migrasomes May Originate from Cilia and Represent an Alternative Ciliary Form

This paper identifies migrasomes as originating from cilia, showing their correlation with EMT in cancer and tissue repair in fracture healing.

Activation pathway of the human voltage-gated proton channel

This study determines the activation pathway of the human voltage-gated proton channel hHV1 using computational methods, revealing voltage-driven structural changes and lipid effects validated by experiments.

DTH1-dependent remodeling of the lipid and protein environment of lipid droplets during nutrient recovery in Chlamydomonas

This study investigates the role of DTH1 in remodeling lipid and protein environments of lipid droplets during nutrient recovery in Chlamydomonas, revealing its impact on lipid degradation and organelle communication.

Sensory receptor expansion and neural accommodation in butterfly color vision

The paper investigates how butterflies expand their color vision by adding a second R7 photoreceptor and how the brain accommodates this change through developmental mechanisms.