T-cell and B-cell Immunology

Initial TCR Signal Strength Imprints GATA3 and Tbet Expression Driving T-helper Cell Fate Decisions

The paper shows that initial TCR signal strength sets early expression of GATA3 and Tbet, influencing Th2 differentiation, while cytokine signals modulate later differentiation outcomes.

Conditioned immunological memory: implication for cognition of immune cells

This study demonstrates that immune cells can undergo classical conditioning, forming associations between hapten analogues and conjugates, leading to conditioned immunological memory and humoral immunosuppression.

Resident memory T cells in dirty mice suppress innate cell activation and infiltration into the skin following stimulation with alarmins.

CD39 is expressed on functional effector and tissue resident memory CD8+ T cells

This study identifies CD39 expression on functional effector and tissue-resident memory CD8+ T cells, showing its role in memory differentiation and function, distinct from its role in T cell exhaustion.

T cell responsiveness to IL-10 defines the immunomodulatory effect of costimulation blockade via anti-CD154 and impacts transplant survival

This study shows that T cell responsiveness to IL-10 determines the effectiveness of costimulation blockade therapy in transplant models, impacting graft survival.

Steady-state, therapeutic, and helminth-induced IL-4 compromise protective CD8 T cell bystander activation

The paper investigates how IL-4 from therapeutic or helminth-induced sources affects bystander activation of CD8 T cells, showing it modulates cytotoxic mediator expression without fully blocking the process.

Thymic self-recognition-mediated TCR signal strength modulates antigen-specific CD8+ T cell pathogenicity in non-obese diabetic mice

The paper shows that CD8+ T cells with stronger TCR signals in NOD mice are more pathogenic in diabetes, suggesting they are targets for treatment.

Akt2 deficiency impairs Th17 differentiation, augments Th2 differentiation, and alters the peripheral response to immunization

This study shows Akt2 deficiency impairs Th17 differentiation, enhances Th2 differentiation, and reduces peripheral immune responses to immunization.

A dominant role of TGFβ in regulating T-cell size and physiology

This study shows TGFβ profoundly regulates T-cell size and physiology by modulating gene expression and transcription factor networks, independent of other cytokines.

Stem cell-like memory T cells are closely related to follicular helper T lymphocytes

The paper identifies cytokine combinations that enhance the expansion of stem cell-like memory T cells and links them to follicular helper T cell differentiation.

Disruptors of sestrin-MAPK interactions rejuvenate T cells and expand TCR specificity

This paper develops DOS, a first-in-class disruptor of sestrin-MAPK complexes, which rejuvenates senescent T cells and expands TCR specificity by generating new T cell clones.

T-follicular helper cells are epigenetically poised to transdifferentiate into T-regulatory type-1 cells

The paper investigates the epigenetic mechanisms enabling T-follicular helper cells to transdifferentiate into TR1 cells, finding that TR1 gene programs are pre-established in TFH cells.

Longitudinal Proteomic Profiling of T Cell Differentiation In Vivo Reveals Biochemical Remodeling Underlying Exhaustion

This study profiles longitudinal proteomic and phosphoproteomic changes in CD8 T cells during acute and chronic infections, identifying exhaustion-associated proteins and phosphosites with potential therapeutic relevance.

Epigenetic control of CD8+ T cell tissue homing and tissue resident memory T cell precursors by the histone methyltransferase SUV39H1

This study shows that SUV39H1 depletion in CD8+ T cells enhances tissue homing and TRM differentiation, improving therapeutic outcomes in infection and cancer.

A Catalog of the Public T-cell Response to Cytomegalovirus

The paper provides a catalog of public T-cell receptors specific to cytomegalovirus (CMV) and explores their antigen specificity and subgroup variations.

Origins and diversity of pan-isotype human bone marrow plasma cells

The paper investigates the origins and diversity of human bone marrow plasma cells, identifying distinct functional profiles and sources of IgE-producing cells in peanut allergy.

Follicular helper- and peripheral helper-like T cells drive autoimmune disease in human immune system mice

The paper shows that PD-1+CD4+ Tfh-like and Tph-like cells in human immune system mice drive autoimmune disease, with disease progression linked to HLA-restricted T cell-APC interactions.

IL-2 enhances effector function but suppresses follicular localization of CD8+ T cells in chronic infection

This study shows IL-2 enhances CD8+ T cell effector function but inhibits CXCR5+ TPEX cell formation and follicular infection control in chronic LCMV infection.

Dynamic Changes in Lymphocyte Populations Establish Zebrafish as a Thymic Involution Model

This study shows zebrafish thymic B cells increase relative to T cells after involution, similar to humans, and establishes zebrafish as a model for studying thymic involution.

Plasma cell heterogeneity is driven by type of immune challenge

This study identifies five plasma cell subsets in humans and mice, showing their heterogeneity is driven by immune challenge type and B cell origin.

Unusual lineage plasticity revealed by YY1 knockout in pro-B cells

This study shows that YY1 knockout in pro-B cells leads to lineage plasticity, enabling the generation of T lineage cells and revealing YY1's role in lineage commitment.

34-parameter full spectrum immunophenotyping panel of human regulatory and effector lymphocytes

This paper introduces a 34-marker flow cytometry panel for comprehensive immunophenotyping of regulatory and effector lymphocytes in human samples.

Identification of B cell subsets based on antigen receptor sequences using deep learning

This paper introduces BCR-SORT, a deep learning model that predicts B cell subsets from BCR sequences, revealing inter-individual heterogeneity in memory B cell evolution post-COVID-19 vaccination.

Seq2MAIT: A Novel Deep Learning Framework for Identifying Mucosal Associated Invariant T (MAIT) Cells

Seq2MAIT identifies MAIT cells from bulk TCR-sequencing data using a transformer-based model, achieving AUROC >0.80 across datasets.

Germinal centers are permissive to subdominant antibody responses

The paper uses in silico simulations to show that immunodominance in germinal centers is driven by the most immunogenic antigen, but increased vaccine valence may reduce this dominance.

Microbiota-derived inosine programs protective CD8+ T cell responses against influenza in newborns

This study identifies microbiota-derived inosine as a key factor in promoting CD8+ T cell responses against influenza in newborns by reversing epigenetic dysregulation.

A time-resolved meta-analysis of consensus gene expression profiles during human T-cell activation

The paper identifies time-resolved gene expression profiles during T-cell activation using meta-analysis and validates them in CAR T-cell data.

T-cell receptor sequences correlate with and predict gene expression levels in T cells

The paper examines the relationship between T cell receptor sequences and gene expression levels, finding correlations and predictive associations.

Embryonic lymphocytes contribute to a genetic form of autoimmune inflammation

This study shows that embryonic-like progenitors contribute to autoreactive T-cells in Omenn Syndrome, leading to autoimmune inflammation.

An essential role for miR-15/16 in Treg suppression and restriction of proliferation

This study shows that miR-15/16 in Tregs is essential for immune tolerance by restricting proliferation and maintaining suppressive function, preventing inflammation.