Spine and Intervertebral Disc Pathology

HMGB1 mediates macrophage recruitment and regional intervertebral disc tissue functional and mechanical property changes following injury.

This study shows HMGB1 promotes macrophage recruitment and worsens intervertebral disc degeneration after injury, with knockout mice showing reduced mechanical and structural damage.

VEGFA critically controls neurovascular invasion and chronic low back pain during intervertebral disc degeneration

This study shows that VEGFA drives neurovascular invasion in degenerating intervertebral discs and contributes to chronic low back pain, with its inhibition preventing pain behaviors.

Intervertebral disc impairments in a mouse model of Alzheimer's Disease

This study examines intervertebral disc (IVD) impairments in a mouse model of Alzheimer's Disease, finding no increased degeneration but altered mechanical properties and volume.

An in vivo rat lumbar spine instability model induced by intervertebral disc injury

This study establishes a rat model of lumbar spine instability through intervertebral disc injury and evaluates musculature adaptations.

Mineral Phase Changes During Intervertebral Disc Degeneration

The paper analyzes mineral phase changes in intervertebral discs from dogs, finding that herniated discs contain crystalline hydroxyapatite while non-herniated discs have amorphous calcium phosphate.

Single-Cell and WGCNA Integrative Analysis Reveal the Key Chondrocytes Niches and Pathogenic Genes in Intervertebral Disc Degeneration

This study integrates single-cell RNA sequencing and WGCNA to identify chondrocyte subtypes, hub genes, and inflammatory pathways in intervertebral disc degeneration.

Lactate metabolic coupling between the endplates and nucleus pulposus via MCT1 is essential for intervertebral disc health

This study shows that lactate transfer via MCT1 between nucleus pulposus and endplate cells is essential for intervertebral disc health, as its absence leads to degeneration.

Parallel networks to predict TIMP and protease cell activity of Nucleus Pulposus cells exposed and not exposed to pro-inflammatory cytokines

The paper uses a Parallel Network methodology to predict TIMP and protease activity in NP cells under various mechanical and inflammatory conditions.

Oral citrate supplementation mitigates age-associated pathological intervertebral disc calcification in LG/J mice

This study shows oral K3Citrate reduces disc calcification in LG/J mice without affecting bone structure or locomotion, suggesting Ca2+ chelation as a potential mechanism.

Nucleus Pulposus Cell Network Modelling in the Intervertebral Disc

The paper develops a regulatory network model of nucleus pulposus cells to simulate ECM regulation in intervertebral discs, showing how perturbations affect catabolic and anabolic processes.

Genome-wide meta-analysis conducted in three large biobanks expands the genetic landscape of lumbar disc herniations

This study conducts a genome-wide meta-analysis across three biobanks to identify new genetic loci associated with lumbar disc herniation, expanding the known genetic landscape.

Therapeutic effects of PDGF-AB/BB against cellular senescence in human intervertebral disc

This study shows that PDGF-AB/BB treatment reduces senescence in human intervertebral disc cells by modulating gene expression related to cell cycle, metabolism, and oxidative stress.

SIRT6 loss causes intervertebral disc degeneration in mice by promoting senescence and SASP status

This study shows that SIRT6 loss in mice leads to intervertebral disc degeneration by promoting senescence and SASP through changes in histone modifications, DNA accessibility, and autophagy.

Environmentally stressed human nucleus pulposus cells trigger the onset of discogenic low back pain

The paper identifies a stress-induced subtype of nucleus pulposus cells in degenerating intervertebral discs that trigger discogenic low back pain.

Single-cell Atlas Unveils Cellular Heterogeneity and Novel Markers in Human Neonatal and Adult Intervertebral Discs

The paper generates and compares single-cell atlases of human neonatal and adult intervertebral discs to identify cellular heterogeneity, sub-populations, and developmental trajectories.

Protocol for disease-oriented Russian disc degeneration study (RuDDS) biobank facilitating functional omics studies of lumbar disc degeneration

This paper describes a biobank protocol for studying lumbar disc degeneration using clinical and omics data from 1100 participants.

Identification of biological processes and signaling pathways in the stretched nucleus pulposus cells

The paper identifies altered biological processes and signaling pathways in stretched nucleus pulposus cells using transcriptomic analysis of a rat dataset.

The role of miR-31-5p in the development of intervertebral disk degeneration and its therapeutic potential

This study identifies miR-31-5p as a key regulator of intervertebral disc degeneration, showing it promotes cell proliferation, inhibits apoptosis, and reduces matrix degradation by targeting the SDF-1/CXCR7 axis.

DIPPER: a spatiotemporal proteomics atlas of human intervertebral discs for exploring ageing and degeneration dynamics

DIPPER provides a spatiotemporal proteomics atlas of human intervertebral discs, revealing region-specific regulatory profiles and a hydration matrisome linked to MRI intensity.

Simulating intervertebral disc cell behavior within 3D multifactorial environments

This paper develops a hybrid Agent-based model to simulate intervertebral disc cell behavior in 3D multifactorial environments, showing cell death and viability changes under simulated stress conditions.

Homeostasis of the intervertebral disc requires regulation of STAT3 signaling by the adhesion G-protein coupled receptor ADGRG6

This study identifies ADGRG6 as a regulator of intervertebral disc homeostasis through STAT3 signaling, showing that inhibiting STAT3 reduces disc degeneration in a mouse model.

Downregulation of insulin-like growth factor binding protein 5 is involved in intervertebral disc degeneration via the ERK signaling pathway

Trans-ethnic polygenic analysis supports genetic overlaps of lumbar disc degeneration with height, body mass index, and bone mineral density

The paper uses polygenic scores to show genetic overlaps between lumbar disc degeneration and height, BMI, and BMD in Chinese and Japanese cohorts.