Circadian rhythm and melatonin

Genome-wide association analyses of chronotype in 697,828 individuals provides new insights into circadian rhythms in humans and links to disease

This study identifies 351 new genetic loci associated with chronotype using data from 697,828 individuals and links them to circadian biology and disease.

Molecular Diversity of Intrinsically Photosensitive Ganglion Cells

The paper identifies novel genes and reveals molecular diversity in mouse intrinsically photosensitive retinal ganglion cells (ipRGCs), showing unexpected complexity in their gene expression patterns.

The lysine demethylase dKDM2 is non-essential for viability, but regulates circadian rhythms in Drosophila

This study shows that dKDM2 is not essential for Drosophila viability but regulates circadian rhythms, with loss-of-function mutants showing arrhythmic behavior and overexpression causing shorter periods.

Systematic analysis of mouse genome reveals distinct evolutionary and functional properties among circadian and ultradian genes

The paper analyzes mouse genome data to show ultradian genes are more evolutionarily conserved and linked to dawn/dusk transitions.

Genome-wide association study of circadian rhythmicity in 71 500 UK Biobank participants and polygenic association with mood instability

This study identifies genetic loci associated with circadian rhythmicity using UK Biobank data and finds polygenic associations with mood instability and major depressive disorder.

Bootstrapping and Empirical Bayes Methods Improve Rhythm Detection in Sparsely Sampled Data

The paper improves rhythm detection in sparsely sampled genome-wide expression time series using bootstrapping and empirical Bayes methods, showing better consistency than existing methods.

Non-canonical circadian oscillations in Drosophila S2 cells drive gene-expression cycles coupled to metabolic oscillations

The paper shows Drosophila S2 cells exhibit daily gene and metabolic oscillations without canonical circadian regulators.

Entrainment of circadian rhythms depends on firing rates and neuropeptide release of VIP SCN neurons

This study identifies how VIP SCN neurons use firing rates and neuropeptide release to entrain circadian rhythms in gene expression and behavior.

miR-263b controls circadian rhythms and structural plasticity of small ventral lateral neurons by inhibition of Beadex

This study identifies miR-263b as a regulator of circadian rhythms in Drosophila by inhibiting Beadex expression, affecting structural plasticity of sLNv neurons.

Co-existing feedback loops generate tissue-specific circadian rhythms

The paper identifies tissue-specific circadian feedback loops by fitting mathematical models to gene expression data from different mammalian tissues.

A bHLH-PAS protein regulates light-dependent diurnal rhythmic processes in the marine diatom Phaeodactylum tricornutum

This study identifies PtbHLH1a, a bHLH-PAS protein in Phaeodactylum tricornutum, that regulates light-dependent diurnal rhythms, cell cycle, and gene expression, with conserved homologs across diatom species.

Theory of Circadian Metabolism

The paper extends a framework for quantifying growth and proteome composition to circadian metabolism in cyanobacteria, showing that storing carbon and nitrogen leads to an optimal growth strategy constrained by slow proteome relaxation.

Intrinsically photosensitive retinal ganglion cell mediated pupil function is impaired in Parkinson’s disease

This study shows that melanopsin-mediated pupil responses are impaired in early-stage Parkinson's disease, suggesting a potential biomarker for disease detection and monitoring.

Intercellular signaling network underlies biological time across multiple temporal scales

The paper identifies a multiscale temporal regulatory network involving genes that regulate circadian, cell cycle, and aging processes, enriched for signal transduction, metabolism, and stress response genes.

Coordination of robust single cell rhythms in the Arabidopsis circadian clock via spatial waves of gene expression

The paper examines single-cell circadian rhythms in Arabidopsis seedlings, revealing robust oscillations and spatial waves of gene expression that coordinate clock activity across the plant.

A population-based human enCYCLOPedia for circadian medicine

The paper identifies rhythmic gene expression across human tissues using computational methods and highlights implications for circadian medicine in cardiovascular disease.

Epigenetic regulation of the circadian gene Per1 in the hippocampus mediates age-related changes in memory and synaptic plasticity

This study shows that HDAC3 restricts long-term memory and synaptic plasticity in aging hippocampus by repressing Per1, a circadian gene, without affecting circadian rhythms.

Circadian clock neurons mediate time-of-day dependent responses to light

This study investigates how circadian clock neurons in the suprachiasmatic nucleus (SCN) respond to light and mediate time-of-day dependent rhythms in behavior.

A (blue) light in the dark: Blue light modulates oscillatory alpha activity in the occipital cortex of totally visually blind individuals with intact non-visual photoreception

This study shows that blue light modulates alpha rhythm in the occipital cortex of totally blind individuals with non-visual light perception, suggesting ipRGCs influence brain activity beyond vision.

Transcription factor activity rhythms and tissue-specific chromatin interactions explain circadian gene expression across organs.

The paper investigates how circadian gene expression is regulated across tissues by analyzing transcription factor activity rhythms and chromatin interactions in mouse tissues.

A sleep-regulatory circuit integrating circadian, homeostatic and environmental information in Drosophila

This study identifies a circuit in Drosophila where DN1p neurons integrate circadian, homeostatic, and environmental cues to regulate sleep onset.

Cell-autonomous regulation of astrocyte activation by the circadian clock protein BMAL1

This study shows BMAL1 regulates astrocyte activation and function through cell-autonomous and non-cell-autonomous mechanisms, impacting neuronal survival and brain health.

Identification of novel circadian transcripts in the zebrafish retina

The paper identifies novel circadian transcripts in the zebrafish retina and distinguishes between light-entrained and free-running oscillations.

Natural changes in light interact with circadian regulation at promoters to control gene expression in cyanobacteria

The paper shows natural light changes affect circadian gene expression in cyanobacteria through RNA polymerase recruitment controlled by transcription factors.

Salt-inducible kinase 3 regulates the mammalian circadian clock by destabilizing PER2 protein

This study shows that SIK3 regulates circadian rhythms in mice by destabilizing PER2 protein through phosphorylation.

Characterization of a thalamic nucleus mediating habenula responses to change in illumination

The paper identifies a thalamic nucleus that mediates habenula responses to changes in illumination using calcium imaging and optogenetics in zebrafish.

Mapping Quantitative Trait Loci Underlying Circadian Light Sensitivity In Drosophila

This study identifies a major QTL on chromosome 2 associated with circadian light sensitivity in Drosophila and finds that the timeless s/ls polymorphism contributes to phenotypic variation.

FlyClockbase: Importance of Biological Model Curation for Analyzing Variability in the Circadian Clock of Drosophila melanogaster by Integrating Time Series from 25 Years of Research

The paper curates and integrates circadian clock time series data from Drosophila melanogaster to analyze variability in core clock proteins, revealing unexpected differences in peak time variance between PERIOD and TIMELESS.

Translational contributions to tissue-specificity in rhythmic and constitutive gene expression.

The paper investigates how translation efficiency contributes to tissue-specific rhythmic and constitutive gene expression in kidney and liver, revealing translational control mechanisms and compensation effects.

Masking of a circadian behavior in larval zebrafish involves the thalamo-habenula pathway

This study shows blue light masks circadian behavior in larval zebrafish via a thalamo-habenula pathway, while red light does not.