Muscle Physiology and Disorders

Altered Relaxation and Mitochondria-Endoplasmic Reticulum Contact Sites Precede Major (Mal)adaptations in Aging Skeletal Muscle and are Prevented by Exercise

This study identifies early aging-related changes in muscle MERC ultrastructure and proteome, which are reversed by exercise, suggesting potential therapeutic targets for sarcopenia.

Transcriptome remodeling and adaptive preservation of muscle protein content in hibernating black bears

This study identifies transcriptional changes in black bears during hibernation that preserve muscle protein content through mTORC1 signaling and BCAA metabolism.

Immune vascular dialogue coordinates muscle maintenance following damage in Drosophila

This study identifies a novel immune-vascular communication program in Drosophila that coordinates muscle maintenance after damage through macrophage-derived signals and ECM organization.

TRIM32 controls timely cell cycle exit in muscular differentiation through c-Myc down-regulation

This study shows that TRIM32 loss in muscle cells delays differentiation by stabilizing c-Myc mRNA, contributing to LGMDR8 pathogenesis.

In vivo self-renewal and expansion of quiescent stem cells from a non-human primate

The paper identifies and characterizes quiescent stem cells in a non-human primate, showing their in vivo self-renewal and similarity to human cells.

Changes in serial sarcomere number of five hindlimb muscles across adult aging in rats

This study examines age-related changes in serial sarcomere number across five hindlimb muscles in rats at four aging timepoints, finding significant SSN loss contributing to muscle mass decline.

Slit1 -a MET target gene in the embryonic limbs, prevents premature differentiation during mammalian myogenesis.

The paper identifies Slit1 as a MET target gene that prevents premature differentiation during mammalian myogenesis by regulating progenitor cell migration and muscle development.

High resolution kinematic approach for quantifying impaired mobility of dystrophic zebrafish larvae

This paper develops a high-resolution kinematic method to quantify impaired mobility in dystrophic zebrafish larvae, finding significant differences in swimming performance between mutants and wild-types.

PSME3 Regulates Migration and Differentiation of Myoblasts

This study shows PSME3 regulates myoblast migration and differentiation by interacting with NUDC and modulating cell adhesion proteins, independent of proteasome activity.

Parkin overexpression attenuates muscle atrophy and improves mitochondrial bioenergetics but fails to improve key histological features in a mouse model of Duchenne Muscular Dystrophy

This study shows that Parkin overexpression reduces muscle atrophy and improves mitochondrial bioenergetics but does not improve key histological features in a DMD mouse model.

Multi-modal analysis of satellite cells reveals early impairments at pre-contractile stages of myogenesis in Duchenne muscular dystrophy

This study identifies early impairments in satellite cells of a porcine DMD model using multi-omics analysis, showing intrinsic genetic defects rather than environmental factors.

Integrated Multi-omic Profiling Reveals Early Regulatory Events in Dexamethasone Muscle Atrophy

The paper uses multi-omic profiling to study early regulatory changes in dexamethasone-induced muscle atrophy in C2C12 cells, identifying mitochondrial gene expression and alternative splicing alterations.

Early endosome disturbance and endolysosomal pathway dysfunction in Duchenne muscular dystrophy

This study identifies endosomal pathway dysfunction in DMD muscle cells and shows that Rab5 upregulation contributes to endosomal defects, which can be mitigated by Rab5 knock-down or dystrophin restoration.

Fibrillin-Related Proteins Control Calcium Homeostasis in Dystrophic Muscle Across Species

This study shows that fibrillin-related proteins regulate calcium homeostasis in dystrophic muscle across species, linking ECM integrity to calcium control.

Proteomic profiling uncovers sexual dimorphism in the muscle response to wheel running exercise in the FLExDUX4 murine model of facioscapulohumeral muscular dystrophy

This study uses proteomics to show sex-specific differences in mitochondrial protein response to exercise in a mouse model of FSHD, highlighting potential sex-specific biomarkers.

MuRF1 partners with TRIM72 to impair insulin signalling in skeletal muscle cells

This study identifies TRIM72 as a novel MuRF1-interacting protein that contributes to impaired insulin signaling in skeletal muscle cells, linking MuRF1 to muscle atrophy and insulin resistance.

Muscle stem cells in Duchenne muscular dystrophy exhibit molecular impairments and altered cell fate trajectories impacting regenerative capacity

This study uses scRNA-seq to show that DMD satellite cells have molecular impairments and altered differentiation trajectories, leading to reduced regenerative capacity, with autophagy induction potentially rescuing differentiation.

Long-term, age-associated activity quantification in the DE50-MD dog model of Duchenne muscular dystrophy (DMD)

The paper quantifies age-associated activity changes in DE50-MD dogs using accelerometers, finding reduced activity and increased rest time in affected dogs compared to controls.

A zebrafish model of Bethlem myopathy reveals CaV1.1 as the missing link between collagen type VI deficiency and muscle dysfunction

This study uses a zebrafish model of Bethlem myopathy to show that collagen VI deficiency disrupts CaV1.1 function, leading to increased sarcoplasmic reticulum Ca2+ leak and muscle dysfunction.

KLHL41 orchestrates sarcomere assembly and size to drive skeletal muscle hypertrophy in vivo

This study identifies KLHL41's role in sarcomere assembly and muscle growth in zebrafish models of nemaline myopathy, revealing its importance in myofibril formation and cross-bridge regulation.

The TWEAK/Fn14 signaling promotes skeletal muscle wasting during cancer cachexia

This study shows that inhibiting the TWEAK/Fn14 signaling reduces skeletal muscle wasting and tumor growth in cancer cachexia models.

Chronic and Acute Mediators of Passive Viscoelasticity in Human Skeletal Muscle Fibers

The paper examines how chronic resistance training and acute fatigue affect passive viscoelastic properties of human skeletal muscle fibers, finding greater responsiveness in males than females.

Collablots: Quantification of collagen VI levels and its structural disorganisation in cell cultures from patients with collagen VI-related dystrophies

This paper introduces a method called collablot to quantify collagen VI levels and structural disorganisation in cell cultures from patients with collagen VI-related dystrophies, showing its effectiveness in detecting treatment effects and structural changes.

A comprehensive spatiotemporal map of dystrophin isoform expression in the developing and adult human brain

This paper maps dystrophin isoform expression across human brain development and adulthood, revealing novel expression patterns in neurons and synapses.

Validation of Duchenne muscular dystrophy candidate modifiers using a CRISPR-Cas9-based approach in zebrafish

The paper validates new genetic modifiers of Duchenne muscular dystrophy using a zebrafish CRISPR-based screening approach.

Control of myogenesis by the E3 ubiquitin ligase CUL3-BTBD9

This study identifies CUL3-BTBD9 as an E3 ubiquitin ligase essential for myogenesis by ubiquitylating CAV1 and regulating insulin signaling in myoblasts.

Exercise Related microRNAs in C. elegans Regulate Calcium Homeostasis and Mitochondrial Dynamics: Conserved pathways, Divergent mircoRNAs

This study identifies exercise-related microRNAs in C. elegans that regulate calcium homeostasis and mitochondrial dynamics, showing conserved pathways but divergent microRNAs across species.

Aberrant Fibro-Adipogenic Progenitor Subpopulations Drive Volumetric Muscle Loss-Induced Fibrosis

This study identifies an aberrant FAP subpopulation in VML that drives fibrosis and presents potential targets for scarless muscle regeneration.

The Impact of Frailty Syndrome on Skeletal Muscle Histology: Preventive Effects of Exercise

This study examines how frailty syndrome affects skeletal muscle histology in mice and shows that exercise can prevent these negative changes.

Integrated single cell functional-proteomic profiling of human skeletal muscle reveals a shift in cellular specificity in nemaline myopathy

This paper introduces SMPFO, a method combining fluorescence assays and proteome profiling to study skeletal muscle, revealing reduced myofiber subtype divergence in nemaline myopathy.