Muscle Physiology and Disorders

Unconventional myosin VI is involved in the regulation of muscle energy metabolism

This study shows that myosin VI regulates mitochondrial function and energy metabolism in skeletal muscle by affecting respiratory capacity, ATP production, and fiber type composition.

The glycosyltransferase POGLUT1 regulates muscle stem cell development and maintenance in mice

This study shows that POGLUT1 is essential for muscle stem cell development and maintenance in mice, with loss of function leading to muscle defects and impaired repair.

Epigenetic small molecule screening identifies a new HDACi compound for ameliorating Duchenne muscular dystrophy

The paper screens epigenetic small molecules in a zebrafish DMD model to identify SR-4370, a new HDACi that ameliorates muscle degeneration.

Unveiling the neuro-vascular interplay in the skeletal muscle in health, injury and disease

The paper identifies kranocytes as sensory platforms in neuromuscular junctions that connect adjacent junctions, interact with microvasculature, and respond to injury or disease.

Dystrophin interacts with Msp300 to Regulate Myonuclear Positioning and Microtubule Organization

This study identifies Dystrophin's role in maintaining myonuclear spacing through its interaction with Msp300 and regulation of microtubule organization during Drosophila myogenesis.

Alterations of the skeletal muscle nuclear proteome after acute exercise reveals a post-transcriptional influence.

This study identifies changes in the skeletal muscle nuclear proteome after acute exercise, revealing post-transcriptional effects on mRNA processing and splicing.

Combined stimuli of elasticity and microgrooves form aligned myotubes that characterize slow-twitch muscles

This study shows that soft elasticity and microgrooves promote the formation of slow-twitch muscle-like myotubes by enhancing fiber-type markers and orientation.

CEBPβ regulates myoblast proliferation and myogenic differentiation during human myogenesis and rescues defective differentiation in FSHD

This study shows CEBPβ regulates human myoblast proliferation and differentiation, and its altered expression contributes to defective myogenesis in FSHD.

Combined aerobic and resistance exercise training alters the spatial transcriptome of skeletal muscle in young adults

This study examines how combined aerobic and resistance exercise training affects the spatial transcriptome of skeletal muscle in young adults, identifying fiber type-specific gene expression changes and shifts in interstitial cell populations.

Muscle stem cells produce a protective Fibrillin-1 matrix to prevent precocious activation.

This paper identifies Fibrillin-1 as a Notch-regulated matrix protein that maintains muscle stem cell quiescence by shielding them from mitogenic signals, and shows its loss leads to muscle dysfunction in Marfan syndrome.

From Development to Regeneration: Insights into Flight Muscle Adaptations from Bat Muscle Cell Lines

This paper establishes bat muscle cell lines and analyzes their transcriptomic and metabolic profiles to study muscle regeneration and flight muscle biology in bats.

Loss of NRMT1 allows expression of multiple differentiation pathways and alters transcription of secreted proteins in C2C12 myoblasts

This study shows that NRMT1 loss in C2C12 myoblasts disrupts muscle differentiation by altering gene expression related to cell cycle, muscle specification, and other lineage pathways.

Large MAF Transcription Factors Reawaken Evolutionarily Dormant Fast-Glycolytic Type IIb Myofibers in Human Skeletal Muscle

This study identifies large MAF transcription factors as inducers of type IIb myofibers in humans, enhancing glycolytic capacity and correlating with power training.

Myonuclear domain-associated and central nucleation-dependent spatial restriction of dystrophin protein expression in a novel DMD mouse model

This paper introduces a novel DMD mouse model with non-uniform dystrophin expression and shows that partial dystrophin expression protects against muscle pathology.

Hyperactivation of TAK1 causes skeletal muscle pathology reminiscent of inflammatory myopathies

This study shows that hyperactivation of TAK1 in adult mice causes skeletal muscle pathology similar to inflammatory myopathies, while low activation improves muscle mass.

JAG2-related muscular dystrophy and Notch signaling dysfunction in muscle stem cells

This study investigates JAG2-related muscular dystrophy by examining the role of Notch signaling in muscle stem cells, finding that JAG2 variants disrupt both autocrine and paracrine Notch signaling, impairing muscle regeneration.

Immune aging impairs muscle regeneration via macrophage-derived anti-oxidant selenoprotein P

This study identifies that immune aging impairs muscle regeneration by altering macrophage-derived antioxidant selenoprotein P expression and function in aged mice.

Gradient of Wnt signaling facilitates Mef2 heterogeneity and limits commitment of the developmental muscle progenitor pool

The paper identifies a spatial gradient of Wnt signaling that restricts Mef2 expression in Drosophila muscle progenitors, maintaining a less committed state and preserving the progenitor pool.

Microtubules coordinate mitochondria transport with myofibril morphogenesis during muscle development

This study shows microtubules coordinate mitochondria transport and myofibril formation during muscle development in Drosophila and mammals.

Mitochondrial-targeted plastoquinone therapy ameliorates early onset muscle weakness that precedes ovarian cancer cachexia in mice

This study shows mitochondrial-targeted plastoquinone SkQ1 reduces early muscle weakness in ovarian cancer mice by improving calcium handling and mitochondrial function, without preventing atrophy.

Tribbles 3 blunts exercise-induced skeletal muscle adaptation

This study shows that TRB3 overexpression in skeletal muscle reduces exercise-induced adaptations by impairing glucose metabolism and mitochondrial biogenesis.

Multi-scale machine learning model predicts muscle and functional disease progression in FSHD

This paper develops a multi-scale machine learning model to predict muscle and functional disease progression in FSHD using MRI and clinical data, achieving strong predictive performance in holdout datasets.

Gene-corrected human iPSC-derived cardiomyocytes and skeletal muscles reveal partial dystrophin Dp427 preservation and cardiac Dp116 expression in Duchenne muscular dystrophy

The paper uses hiPSCs to study DMD, finding preserved cardiac dystrophin but reduced skeletal muscle dystrophin and cardiac Dp116 expression.

Transcriptomic Suppression of Immune and Regenerative Signalling in Skeletal Muscle of Patients with Chronic Kidney Disease

This study identifies transcriptomic changes in CKD muscle, showing suppressed immune and regenerative pathways, with 76 differentially expressed genes.

Late-Stage Skeletal Muscle Transcriptome in Duchenne muscular dystrophy shows a BMP4-Induced Molecular Signature

The paper identifies a BMP4-induced molecular signature in late-stage DMD skeletal muscle by comparing transcriptomes of DMD patients and BMP4-stimulated cells.

Human-specific lncRNA TMEM9B-AS1 is downregulated in skeletal muscle of individuals with type 2 diabetes and regulates ribosomal biogenesis

This study identifies TMEM9B-AS1, a human-specific lncRNA downregulated in type 2 diabetes skeletal muscle, which regulates ribosomal biogenesis by stabilizing MYC mRNA through interaction with IGF2BP1.

Failure to resolve inflammation contributes to juvenile onset cardiac damage in a mouse model of Duchenne Muscular Dystrophy

This study shows that the D2-mdx mouse model exhibits juvenile-onset cardiac damage due to unresolved inflammation, and pro-resolution therapy can mitigate fibrotic degeneration.

Muscle growth by sarcomere divisions

The paper discovers that sarcomeres divide along the myofibril tension axis during Drosophila muscle development to add new sarcomeres while maintaining mechanical integrity.

Systematic identification of exercise-induced anti-aging processes involving intron retention

This study identifies exercise-induced anti-aging processes in skeletal muscle by analyzing intron retention and its link to genomic instability and mitochondrial function.

RCOR1 promotes myoblast differentiation and muscle regeneration

This study identifies RCOR1 as a positive regulator of myogenesis and skeletal muscle regeneration by interacting with LSD1 and MyoD.