Muscle Physiology and Disorders

Phased ERK function on muscle stem cell plasticity in axolotl

This study shows that ERK signaling duration regulates muscle stem cell plasticity in axolotl tail regeneration, with distinct phases promoting fibroblast and chondrocyte fates.

Unacylated Ghrelin Counteracts Contractile and Mitochondrial Dysfunction in Cancer Cachexia

This study shows that unacylated ghrelin prevents muscle and mitochondrial dysfunction in cancer cachexia by improving muscle mass, mitochondrial function, and reducing proteolysis.

Dysregulated Skeletal Muscle Myosin Super-relaxation and Energetics in Type II Diabetes

This study investigates altered myosin super-relaxation and energy metabolism in type II diabetes using muscle biopsies and proteomic analyses, finding increased super-relaxation and reduced ATP demand.

Dystrophin Dp71 is essential for the development and function of macrophages

This study shows that Dp71 dystrophin is essential for macrophage development and function, as its absence disrupts migration, phagocytosis, and inflammasome activity in mouse macrophages.

GL261 glioblastoma induces delayed body weight gain and stunted skeletal muscle growth in young mice

This study shows GL261 glioblastoma tumors in young mice reduce skeletal muscle growth, mass, and protein synthesis while altering catabolism signaling.

Submaximal eccentric training during immobilization does not prevent serial sarcomere loss or impairments in mechanical function in old or young rats

Exercise-Induced Myostimulin Enhances Muscle Function in Health and Disease

This study identifies myostimulin, a protein derived from C1ORF54, which enhances muscle function and recovery in mice, suggesting its potential as a therapeutic for musculoskeletal diseases.

Polysialylated NCAM distinguishes differentiated myoblasts from proliferating myoblasts prior to fusion

The paper identifies polysialylated NCAM as a marker distinguishing differentiated from proliferating myoblasts before fusion.

Resistance Exercise and Mechanical Overload Upregulate Vimentin for Skeletal Muscle Remodeling

The paper investigates how resistance exercise and mechanical overload upregulate vimentin in skeletal muscle, linking it to hypertrophy and regeneration.

Hepatic Yap1 activates systemic catabolism and muscle loss during organ repair: evidence for a liver-derived common mechanism with cancer cachexia.

This study shows that liver-derived Yap1 activation during organ repair induces systemic catabolism and muscle loss, similar to cancer cachexia.

CtBP1 coordinates synaptic, metabolic and contractile changes induced by denervation in skeletal muscle

Preliminary Insights into the Acute Molecular Responses in C2C12 Myotubes to Hyperthermia and Insulin Treatment.

This study examines gene expression changes in C2C12 myotubes under hyperthermia with and without insulin treatment, finding upregulated metabolic and stress-related genes and insulin's moderating effect on these changes.

The Short Isoform of the Mouse Actin Adaptor Protein Synaptopodin-2 Activates Actin-Responsive Transcription Factors and Enhances Myoblast Fusion

This study identifies the short isoform of SYNPO2 as a pro-myogenic factor that enhances myotube formation and upregulates late myogenic differentiation markers.

Becker muscular dystrophy mice showed site-specific decay of type IIa fibers with capillary change in skeletal muscle

This study investigates BMD mice with specific exon deletions, showing site-specific muscle degeneration, type IIa fiber reduction, and capillary changes linked to nNOS reduction.

Impact of exercise intervention on IGF-1 signaling related to muscle regeneration and physical performance in aged mice

This study shows that exercise improves IGF-1 signaling and muscle function in aged mice, enhancing physical performance and mitigating age-related muscle decline.

Muscle-specific Keap1 deletion enhances force production but does not prevent inactivity-induced muscle atrophy in mice

This study investigates whether muscle-specific Keap1 deletion prevents inactivity-induced muscle atrophy in mice, finding it enhances force production but does not prevent atrophy or weakness after hindlimb unloading.

Inhibiting EZH2 complements steroid effects in Duchenne muscular dystrophy

The paper investigates the role of EZH2 in Duchenne muscular dystrophy and shows that inhibiting EZH2 improves muscle phenotype in Dmd mutant mice when combined with glucocorticoids.

Targeting Galectin-3 to modulate inflammation in LAMA2-deficient congenital muscular dystrophy

This study identifies Galectin-3 as a driver of inflammation in LAMA2-CMD and shows that inhibiting it reduces inflammation and fibrosis in a mouse model.

Modeling statin-induced myopathy with human iPSCs reveals that impaired proteostasis underlies the myotoxicity and is targetable for the prevention

This study uses human iPSC-derived myocytes to model statin-induced myopathy, showing statins impair proteostasis via the mevalonate pathway and identify FOXO1 as a target for prevention.

Single-nuclei sequencing of skeletal muscle reveals subsynaptic-specific transcripts involved in neuromuscular junction maintenance

The paper uses single-nuclei RNA-sequencing to identify NMJ-specific transcripts and shows that Etv4 and Pdzrn4 contribute to NMJ stability through gene regulation and protein interactions.

3D mechanical confinement directs muscle stem cell fate and function

This study shows that 3D mechanical confinement regulates muscle stem cell fate by maintaining stemness and inhibiting differentiation through epigenetic and nuclear changes.

Enhanced expression of Dystrophin, IGF-1, CD44 and MYH3 in plasma and skeletal muscles including Diaphragm of mdx mice after oral administration of Neu REFIX Beta 1,3-1,6 glucan

Changes in motor unit conduction velocity after unilateral lower limb suspension and active recovery correlate with muscle ion channel gene expression

This study examines changes in motor unit conduction velocity after unilateral lower limb suspension and active recovery, finding that ion channel gene expression, particularly K+ transporters, correlates with these changes.

Muscle stem cell activation in response to acute injury is promoted by transient exposure to neutrophil elastase

This study shows that transient neutrophil elastase exposure promotes muscle stem cell activation and regeneration after injury, while chronic exposure impairs it.

Enhancement of Prednisolone efficacy and safety in Duchenne muscular dystrophy via neutrophil elastase inhibition

This paper shows that combining Alvelestat with Prednisolone improves muscle function and reduces side effects in a DMD mouse model.

A skeletal muscle-sympathetic nerve-intestine network underlies muscle inflammation and atrophy induced by immobilization

This study identifies a muscle-sympathetic nerve-intestine network that drives inflammation and atrophy in immobilized muscles, showing that intestinal inflammation contributes to muscle damage.

Human iPSC-derived motor neuron innervation enhances the differentiation of muscle bundles engineered with benchtop fabrication techniques

This study shows that adding human iPSC-derived motor neurons to engineered muscle bundles improves their structural and functional maturity and maintains an oxidative phenotype.

Transcription factors associated with regulation of transcriptome in human thigh and calf muscles at baseline and after six days of disuse

The paper identifies transcription factors regulating gene expression in human soleus and vastus lateralis muscles before and after disuse, finding distinct responses and associations with inflammation and mitochondrial metabolism.

Fibroblast growth factor 21 regulates neuromuscular junctioninnervation through HDAC4 in denervation-induced skeletal muscle atrophy

This study identifies FGF21 as a key driver of denervation-induced skeletal muscle atrophy through HDAC4 regulation, showing that inhibiting FGF21 could mitigate muscle atrophy.

Delivery of a chemically modified noncoding RNA domain improves dystrophic myotube function

This study identifies a pro-myogenic domain in CYTOR and shows that chemically modified RNA delivery improves dystrophic myotube function.