Immunotherapy and Immune Responses

In vivo vaccine generation with a topical small molecule cocktail to eradicates AML and PDAC

This paper presents a small molecule cocktail-based in vivo vaccine strategy that effectively eradicates AML and PDAC by inducing immunogenic cell death and activating immune responses.

Cancer cell-selective ectopic expression of CD20 as an antigen enables rituximab repurposing for solid tumor immunotherapy

This paper demonstrates a strategy to repurpose rituximab for solid tumors by selectively expressing CD20 on cancer cells, enhancing NK cell-mediated cytotoxicity and showing high specificity and safety in multiple models.

Hiltonol and Protamine-RNA stimulation induce an immune-activating transcriptome profile in cDC1s

The paper evaluates how Hiltonol and protamine-RNA stimulate human cDC1s, showing similar transcriptome changes related to immune activation without synergistic effects.

Adenovirus-based vaccines transduce and activate human Langerhans cells

This study shows human Langerhans cells internalize and respond to adenovirus vectors, suggesting a role in vaccine-induced immunity.

Langerhans Cell-targeted Protein Delivery Enhances Antigen-Specific Cellular Immune Response

This study shows that targeting protein antigens to Langerhans cells enhances antigen-specific T cell activation and immune response compared to unmodified antigens.

Development of Dendritic Cell Membrane-Coated Nanoparticles for Antigen-Specific T Cell Engagement

This study develops a combined coating method for dendritic cell membrane-coated nanoparticles, showing improved protein coating and size control, and validates their antigen-specific T cell engagement.

Ontogeny and functional potential of founding dendritic cells in the developing lung

The paper identifies two distinct dendritic cell subsets in fetal and newborn mouse lungs, showing unique ontogeny and functional characteristics compared to adult DCs.

NTX250: A Modular mRNA-Based Immunotherapy Platform for HPV-Associated Cancers with Broad Applicability.

This paper introduces NTX250, an mRNA-based immunotherapy platform for HPV-associated cancers that induces tumor regression and durable immune memory in preclinical models.

The anti-virus T cell response dominates the anti-cancer response in oncolytic virus therapy

This study shows oncolytic virus therapy primarily elicits anti-virus T cell responses rather than anti-cancer responses, explaining limited clinical efficacy in metastatic disease.

Optimized Ex Vivo Differentiation of CD103⁺ Dendritic Cells and High-Efficiency Retroviral Transduction of Mouse Bone Marrow HSCs

Enhancing HLA-DR in Cytotoxic T Lymphocytes is crucial for the development of efficient adoptive T cell Therapies for Breast Cancer

This study shows that enhancing HLA-DR expression in cytotoxic T lymphocytes improves their anti-tumor activity, suggesting strategies to optimize adoptive T cell therapies for breast cancer.

mRNA-Based Designer APCs Elicit Robust CD8⁺ and CD4⁺ T Cell Responses

This paper develops an mRNA-based platform that reprograms somatic cells into designer APCs, enhancing T cell responses against tumors and demonstrating translational potential in human and mouse models.

Immunization with peptide encapsulated within synthetic spores activates T cell responses and reduces tumor growth

This study shows that synthetic spore-like particles (SSHELs) enhance T cell responses and reduce tumor growth in a mouse model by efficiently delivering peptides to dendritic cells.

Resolving cDC2 heterogeneity across human cancer atlases

The paper integrates single-cell RNA sequencing data across cancer types to resolve cDC2 heterogeneity and identify major DC populations in human tumours.

Towards active vaccination against tumour endothelial marker Robo4

A conjugate vaccine targeting Robo4 induces anti-Robo4 antibodies, inhibiting tumour growth and vascular development in mouse models.

Reprogramming the genome of M13 bacteriophage for all-in-one personalized cancer vaccine

This paper develops a reprogrammed M13 bacteriophage platform for personalized cancer vaccines, showing enhanced immune response and tumor eradication.

A Transient Immunostimulatory Niche Synergizes Adoptive and Endogenous Immunity for Enhanced Tumor Control

This paper develops ACTIVATE, a hydrogel-based platform that enhances tumor control by synergizing adoptive and endogenous immunity through localized cytokine delivery and T-cell activation.

Human tonsil organoids reveal innate pathways modulating humoral and cellular responses to ChAdOx1

This study uses human tonsil organoids to investigate innate pathways regulating humoral and cellular responses to ChAdOx1, identifying key roles for IFN- and IL-6.

Development of a Stable Lyophilized Formulation of a Quadrivalent Frame-Shift Peptide Vaccine for Cancer Prevention in Lynch Syndrome

The paper develops a stable lyophilized formulation for a quadrivalent frame-shift peptide vaccine targeting Lynch syndrome-associated cancers, showing stability for 18 months at ambient temperatures.

Matrix-M(R) adjuvant triggers inflammasome activation and enables antigen cross-presentation through induction of lysosomal membrane permeabilization

This study shows Matrix-M adjuvant induces lysosomal membrane permeabilization, enabling antigen cross-presentation and IL-1β/IL-18 secretion, which contributes to its adjuvant effect.

Cellular and transcriptional profiles of peripheral blood mononuclear cells pre-vaccination predict immune response to preventative MUC1 vaccine

The paper uses single-cell RNA sequencing to identify pre-vaccination immune cell types, gene expression patterns, and pathways that predict immune response to a preventative MUC1 vaccine.

HERV-derived epitopes represent new targets for T-cell based immunotherapies in ovarian cancer

This study identifies HERV-derived epitopes as potential targets for T-cell immunotherapies in ovarian cancer, showing their expression in tumors and immunogenicity in patients.

Chlamydia-induced ex vivo activation of B cells from mice, nonhuman primates, and humans produces large numbers of uniformly activated antigen presenting cells

The paper shows Chlamydia activates B cells across species to become APCs that elicit strong T cell immunity against pathogens and tumors.

Cutting Edge: An mRNA Platform to Create Isolated, Monospecific Th1 Responses

This paper develops an mRNA platform to generate monospecific Th1 responses in mice by encoding epitopes linked to MHCII, demonstrating efficacy against Salmonella infection.

Langerhans Cells Drive Tfh and B Cell Responses Independent of Canonical Cytokine Signals

This study shows Langerhans cells drive Tfh and B cell responses without needing IL-6, type-I interferons, or ICOS-L, challenging the cytokine-centric model of T cell differentiation.

Controlled Release of Poly(U) via Acetalated Dextran Microparticles for Enhanced Vaccine Adjuvant Delivery

This study compares the efficacy of smooth and wrinkled poly(U) encapsulated in Ace-DEX microparticles for vaccine delivery, showing differential immune responses in mice.

Nanomaterials trigger functional responses in primary human immune cells

This study evaluates the effects of nanomaterials on human immune cells, finding that PLGA NPs enhance NK cell function while Si-Gd NPs impair T cell activation.

Intratumoral expression of IL-12 and CD40 ligand (CD154) from plasmids generates antitumor responses that eliminate tumoral T regs

This study combines IL-12 and CD154 plasmid electroporation to enhance antitumor immunity, leading to tumor clearance and reduced T regulatory cells in mouse models.

Ex vivo Model of Functioning Human Lymph Node Reveals Pivotal Role for Innate Lymphoid Cells and Stromal Populations in Response to Vaccine Adjuvant

This study uses ex vivo human lymph node slices to investigate immune responses to a vaccine adjuvant, identifying IL-1β secretion as TLR4-dependent and highlighting roles for innate lymphoid and stromal cells.

TLR2 signaling uniquely destabilizes tumor Tregs to promote cancer immunotherapy

This study shows that TLR2 signaling in innate immune cells within tumors reduces Treg stability, enhancing cancer immunotherapy by improving CD8+ T cell function.