Immunotherapy and Immune Responses

MHC II-expressing bone marrow megakaryocytes are noncanonical antigen presenting cells and activate CD4+ T cells ex vivo

The paper identifies MHC II-expressing bone marrow megakaryocytes as noncanonical antigen-presenting cells capable of activating CD4+ T cells and modulating immune responses.

Contextual control of CD8+ T cell priming by dendritic cell subsets in tumor and inflammatory microenvironments

This study shows that migratory type 1 dendritic cells are more effective than lymph node resident type 1 dendritic cells in priming CD8+ T cells in tumor and inflamed tissues.

Oxygen-generating cryogel vaccines help overcome tumor antigen tolerance and induce durable anti-tumor immunity in prostate cancer

This study develops a cryogel vaccine platform that generates oxygen to overcome tumor antigen tolerance and induce durable anti-tumor immunity in prostate cancer.

Improving peptide vaccine manufacturability without sacrificing immunogenicity: substitution of methionine and cysteine with oxidation-resistant isosteres

This study introduces oxidation-resistant (OXR) antigens by substituting cysteine and methionine with isosteres to improve peptide vaccine manufacturability without compromising immunogenicity.

Antigen presentation requirements for effective cDC1-based cancer immunotherapy

This study shows that in vitro-derived cDC1s resemble tumor-infiltrating DCs and that MHC-I and MHC-II antigen presentation by these cells is essential for effective cancer immunotherapy.

T-Cell Synaptosomes Orchestrate Long-Term Anti-Tumor Immunity via Proliferative and Metabolic Reprogramming

This study shows T-cell immunological synaptosomes (TIS) reprogram APCs and induce durable anti-tumor immunity in a mouse model.

Dendritic cells type 1 control the formation, maintenance, and function of tertiary lymphoidstructures in cancer

This study identifies the role of mature dendritic cells type 1 in forming, maintaining, and functioning tertiary lymphoid structures in cancer.

Tunable Rigid Spikes on Virus-Like Porous Silica Enable Mechanistically Controlled Nanovaccine Platforms

This paper designs tunable, rigid spike architectures on virus-like porous silica nanoparticles to enhance antigen delivery and immune response, showing improved vaccine efficacy compared to traditional adjuvants.

Multiplexed cytokine and antigen mRNA administration generates durable anti-tumor immunity against pancreatic cancer

This study shows that delivering multiple cytokine and antigen mRNAs via nanoparticles can generate strong anti-tumor immunity against pancreatic cancer in mice.

Simultaneous TCR and IL-2 agonism selectively enhances epitope-specific CD8 T cell responses during chronic viral infection

This study shows that targeting IL-2 to antigen-specific CD8 T cells enhances their responses during chronic viral infection while sparing non-targeted populations, and combining this with PD-1 blockade further improves outcomes.

Ready-to-load MHC-I Nanoparticles for High-throughput T cell Screening Studies

The paper introduces VLP-Open HLA nanoparticles for high-throughput T cell screening, enabling efficient peptide exchange and antigen-specific T cell activation.

Pam3CSK4 as a Cross-Species Adjuvant for Polysaccharide Vaccines: Efficacy in Humanized Mouse and Non-Human Primate Models

Pam3CSK4-based adjuvants show promise for boosting protective antibody responses to polysaccharide vaccines.

Antigen-scaffolds loaded with hyper-stable Neoleukin-2/15 expand antigen-specific T cells with a favorable phenotype for adoptive cell therapy

This study shows that Ag-Neo2/15 scaffolds expand antigen-specific T cells with enhanced cytotoxicity and reduced dysfunctionality compared to Ag-IL2/21 scaffolds.

Coated Bacterial Vaccine Platform Overcomes Weak Antigen Immunogenicity: A Functional Approach to GnRH-Based Immunocastration

This study demonstrates that Coated Bacterial Vaccines (CBVs) enhance the immunogenicity of a GnRH-based peptide vaccine, inducing a strong Th2-biased humoral response and effective immunocastration in mice.

Amphiphile-engineered DNA adjuvants stimulate strong type I IFN production in lymph nodes via cytosolic danger-sensing to induce potent cellular and humoral immunity in mice and non-human primates

CD40 agonistic-monovalent streptavidin fusion antibody for targeted neoantigen peptide delivery and potent cancer vaccination

This paper develops a CD40 agonistic-monovalent streptavidin fusion antibody that delivers neoantigen peptides to APCs, enhancing cancer vaccine efficacy and tumor regression in mice.

Feeder-free generation of functional dendritic cells from human pluripotent stem cells

This study develops a feeder-free method to generate functional human dendritic cells from pluripotent stem cells, outperforming monocyte-derived dendritic cells in antigen presentation and T cell activation.

Validation of DoriVac (DNA origami vaccine) efficacy in a metastatic melanoma model

This study validates DoriVac, a DNA origami vaccine, as an effective treatment for metastatic melanoma in mouse models, showing reduced tumor nodules and enhanced immune activation when combined with PD-L1 blockade.

Inhalable Polymeric Nanoparticle Vaccine for Lysosome-targeting Co-delivery of Antigen and Adjuvant with Enhanced Immunoprotection

This paper develops an inhalable nanoparticle vaccine that co-delivers antigen and adjuvant to lysosomes, enhancing immune protection against bacterial pneumonia.

Poly(allylamine)/tripolyphosphate nanocomplex coacervate as a NLRP3-dependent systemic adjuvant for vaccine development

This paper evaluates poly(allylamine)/tripolyphosphate nanocomplex coacervates as a safe systemic adjuvant that activates the NLRP3 inflammasome to enhance Th1-dependent immune responses.

Subunit Vaccination Using Atomic Layering Thermostable Antigen and Adjuvant (ALTA(R)) Platform Elicits Enhanced Humoral and Cellular Immune Responses

This study evaluates the ALTA(R) platform for vaccine formulation, showing enhanced humoral and cellular immune responses compared to liquid adjuvanted vaccines.

DAMP-inducing Peptide Nanofibers and PAMP Combination Adjuvants Boost Functional Lung Tissue-resident Memory CD4+ T Cell Responses

This study shows that combining DAMP-inducing peptide nanofibers with a PAMP enhances lung-resident memory CD4+ T cell responses, improving protection against TB and respiratory diseases.

Histone methyltransferase DOT1L differentially affects the development of dendritic cell subsets

This study shows that DOT1L influences dendritic cell subset development and antigen presentation by modulating histone H3K79 methylation.

In situ generated vaccine-like pyroptosome for personalized cancer immunotherapy

This paper develops a nanoadjuvant that induces localized pyroptosis to generate vaccine-like pyroptosomes, enhancing anti-tumor immunity while avoiding systemic toxicity.

Mutations outside the MR1 antigen binding groove differentially inhibit presentation of exogenous antigens

This study shows that mutations in MR1 outside the antigen binding groove differentially affect exogenous antigen presentation by altering B2M association.

Tumors Located in the Brain Impair the Frequency and Phenotype of Dendritic Cells in Blood and Tumor

This paper identifies systemic reductions in dendritic cell (DC) numbers and activation markers in brain tumor patients, with brain tumors directly contributing to DC defects, and highlights corticosteroid use as a confounding factor.

B cells maintain the homeostasis of splenic marginal zone antigen-presenting cells to promote the anti-viral CD8+ T cell response

This study shows B cells sustain Langerin+ cDC1s via LTβ and MMMs to support anti-viral CD8+ T cell responses during MCMV infection.

Non-cytolytic re-engineering of a viral vaccine vector enables durable effector-memory T cell immunity by reinforcing type I IFN induction

This paper re-engineers a cytolytic viral vector to be non-cytolytic, enhancing CD8 T cell immunity through reinforced type I IFN signaling.

Shared PRAME Epitopes are T-Cell Targets in NUT Carcinoma

This study identifies PRAME as a therapeutic target in NUT carcinoma, showing its high expression and susceptibility to T-cell mediated cytotoxicity via PRAME epitopes presented by HLA Class I molecules.

Redirecting cytomegalovirus immunity against pancreas cancer for immunotherapy

This paper redirects cytomegalovirus (CMV)-specific T cells to target pancreatic cancer, showing improved tumor control and survival in mice.