Retinal Development and Disorders

FGF Signaling Potentiates Müller Glia for Mammalian Retinal Regeneration

This study shows FGF signaling is essential for mammalian retinal regeneration by enabling Muller glia to overcome transcriptional barriers through sustained ERK activation.

Therapeutic restoration of synaptic architecture, retinal and visual function, and prevention of retinal degeneration in a mouse model of retinal dystrophy

This study shows that gene therapy targeting rod photoreceptors can restore synaptic structure, retinal function, and visual acuity in a mouse model of retinal dystrophy.

Megalin deficiency perturbs retinal homeostasis and impairs cathepsin D processing and phagosome-lysosome maturation in the retinal pigment epithelium

This study shows megalin deficiency disrupts retinal homeostasis by impairing phagosome-lysosome maturation and cathepsin D processing in the RPE.

IDENTIFICATION OF HUMAN PHOTORECEPTORS SUITABLE FOR CELL REPLACEMENT STUDIES IN A PRECLINICAL ACHROMATOPSIA MODEL

This study compares human iPSC-derived photoreceptors of different ages for transplantation into a mouse retinal degeneration model, showing structural integration and functional maturation.

Developmental analysis of the cone photoreceptor-less little skate retina reveals distinct Onecut1 isoforms

The paper investigates the development of the little skate retina, identifying a novel onecut1 isoform and its potential regulatory role in photoreceptor development.

Differential and compensatory roles for type I phosphatidylinositol-4-phosphate-5-kinase isoforms in retinal function and health.

This study investigates the roles of PIP5KI isoforms in retinal function and health using mouse models, revealing differential and compensatory effects on photoreceptor degeneration and function.

Transplanted human photoreceptors differentially survive, incorporate, and mature in mildly and severely degenerated mouse retinae

This study shows that transplanted human photoreceptors integrate and mature better in mildly degenerated retinas than severely degenerated ones, depending on the retinal microenvironment.

Erucamide regulates retinal neurovascular crosstalk

This study identifies erucamide as a key regulator of retinal neurovascular crosstalk, showing its role in stabilizing retinal degeneration through TMEM19-mediated activation of myeloid cells.

Redox imbalance dictates dependence on GOT1 versus GOT2 for rod photoreceptor health during aging and stress

This study shows that GOT1 and GOT2 have opposing roles in rod photoreceptor health, with GOT2 acting as a neuroprotective factor under reductive stress conditions.

Reduction of PALS1/Nok disrupts retinal lamination through altered cell positioning while preserving photoreceptor self-organization capacity

This study shows that reduced PALS1/Nok disrupts retinal lamination by altering cell positioning, while photoreceptors retain their self-organization ability.

Circadian clock gates retinal regeneration by orchestrating Cxcl12-dependent immune coordination

This study shows that the circadian clock regulates zebrafish retinal regeneration by controlling immune coordination via the Cxcl12-Cxcr4 axis.

Genome-wide association and multi-omics functional screens reveal the genetic architecture of foveal development

This paper identifies genetic variants and genes associated with foveal hypoplasia using GWAS and multi-omics data, and establishes a zebrafish model to study the condition.

Proliferative Capacity and Neural Lineage Commitment of Muller Glia in the Adult Human Retina

This study shows that human Muller glia can proliferate and differentiate into multiple retinal cell types when exposed to FGF-2 and GSK-3 inhibition.

The Lipidome of iPSC-Derived Retinal Organoids and RPE Partially Resembles that of the Human Retina

This study compares the lipidomic profiles of iPSC-derived retinal organoids and RPE with post-mortem human retina to assess their similarity.

Promfusion: a synthetic fusion promoter enabling enhanced and balanced photoreceptor transgene expression

The paper develops and evaluates two synthetic fusion promoters, Pikali and Nocchu, for enhanced and balanced transgene expression in both rods and cones of retinal organoids.

Developmental Synchrony of Retinal Waves, Apoptosis, and Angiogenesis in Postnatal Retina

This study identifies a unified mechanism linking retinal waves, apoptosis, and angiogenesis in postnatal mouse retina through purinergic signaling and microglial interactions.

Mitochondrial fusion controls the development of specialized mitochondrial structure and metabolism in rod photoreceptor cells

This study shows that mitochondrial fusion via MFN1 and MFN2 is essential for developing specialized mitochondrial structures and maintaining energy metabolism in rod photoreceptor cells.

The P2X7 receptor is an intermediate in the retinoic acid-signaling pathway that induces neuronal remodeling in retinitis pigmentosa

This paper identifies the P2X7 receptor as an intermediary in RA signaling that induces neuronal remodeling in retinitis pigmentosa, showing its role in RGC hyperactivity and hyperpermeability.

Evolutionary tuning of rhodopsin-mediated light protection

This paper shows that rhodopsin's light protection mechanism evolved to sequester toxic retinal and protect retinal cells, with implications for human disease.

Mesenchymal-derived neural progenitors underlie local insulin production and neuronal transdifferentiation during retina regeneration

This study identifies mesenchymal-derived neural progenitors that transdifferentiate into retinal ganglion cells in zebrafish after neuronal ablation, revealing a novel mechanism for retinal regeneration.

Retinal Electrophysiological Patterns in Alzheimer's Disease: A Multi-Domain Signal Processing Framework for Non-Invasive Biomarker Discovery Using a Portable ERG Device

This paper applies multi-domain signal processing to ERG data from AD patients and controls, identifying significant biomarkers that improve AD detection accuracy.

Antisense oligonucleotide allele-specific targeting of EFEMP1 in a patient-derived model of Doyne honeycomb retinal dystrophy

This study develops an allele-specific antisense oligonucleotide to target EFEMP1 in a patient-derived model of Doyne honeycomb retinal dystrophy, reducing extracellular deposits and intracellular lipid accumulation.

Microglia maintain retinal redox homeostasis following ablation of rod photoreceptors in zebrafish

This study shows that microglia in zebrafish retinas clear ROS from dying rod photoreceptors, preventing oxidative stress and off-target cell death.

Melanin regulates mitochondrial dynamics, metabolism and inflammatory signaling to protect the retina

This study shows that melanin in retinal pigment epithelium regulates mitochondrial structure, metabolism, and inflammation, protecting against light-induced retinal damage.

Extrinsic polarity cues control lamination versus cluster-based organisation in vertebrate retinal development

This study shows that extrinsic polarity cues determine whether retinal organoids develop a laminated epithelium or cluster-based organization, revealing plasticity in vertebrate retinal development.

Clinically relevant AAV8-PEX1 gene therapy preserves retinal integrity and function long-term in a murine model of Zellweger spectrum disorder

This study evaluates a gene therapy for Zellweger spectrum disorder, showing long-term preservation of retinal function and structure in mice.

A single Musashi gene allele is sufficient to maintain mouse photoreceptor cells

The paper shows that a single Musashi gene allele is sufficient to maintain photoreceptor function and splicing in mice.

A Knock-In Igfn1iCre transgenic mouse line provides partial developmental access to type-7 bipolar cells

The paper generates an Igfn1iCre knock-in mouse line to study type-7 bipolar cells during development and confirms Igfn1 expression in these cells and other retinal types.

Zebrafish Functional Screening of FDA-Approved Drugs for Autosomal Dominant Retinitis Pigmentosa Caused by RHODOPSIN Q344X Mutation

This study screens FDA-approved drugs in a zebrafish model of autosomal dominant retinitis pigmentosa, identifying four compounds that improve visual behavior by distinct mechanisms.

Lid speculum as effective active and reference electrodes for electroretinography recording in normal rabbits

This study evaluates the use of a metal eyelid speculum as active and reference electrodes for ERG recordings in rabbits, showing reliable signal quality and practical advantages over traditional corneal electrodes.