Circular RNAs in diseases

FindBacksplice: a Tool for Locating Circular RNA Backsplice Coordinates

FindBacksplice locates circular RNA backsplice coordinates using BSJ sequences across any genome version and species.

Circular RNAs accumulate in ageing human placental tissue and in stillbirth, leading to DNA damage and cellular senescence

This study shows that circular RNAs accumulate in aged human placental tissue and in stillbirth cases, causing DNA damage and cellular senescence, and suggests they could be used for stillbirth risk screening.

Circular RNAs in Lotus japonicus Responses to Nutrient Supply and Symbiotic Interactions

The paper identifies circRNAs in Lotus japonicus under different nutrient and symbiotic conditions and suggests their role in regulating symbiosis through miRNA sponging.

The noncoding circular RNA circHomer1 regulates synaptic development and experience-dependent plasticity in mouse visual cortex

This study identifies circHomer1 as a circRNA critical for synaptic development and experience-dependent plasticity in mouse visual cortex through transcriptome analysis and knockdown experiments.

Circular RNA profiling identifies circ5078 as a BMPR2-derived regulator of endothelial proliferation and stress responses

The paper identifies circ5078 as a BMPR2-derived circular RNA that regulates endothelial proliferation and stress responses in PAH, with opposing effects to linear BMPR2 mRNA.

Intracellular auto-circularizing RNA using human tRNA splicing elements

This study identifies human tRNA splicing elements that enable efficient intracellular auto-circularization of RNA, providing a framework for circRNA production.

TGF-β signaling promotes the expression of proviral circular RNA ciTRAN in HIV-1 infection

The paper shows that TGF-β signaling, triggered by HIV-1 Vpr, increases ciTRAN expression through SMAD2/3 recruitment to the SMARCA5 promoter.

Unlocking efficiency: Native circular RNA surpass linear isoforms in RNase P activity

The paper identifies circular RNA isoforms of RNase P in bacteria, fungi, and human cells, showing improved stability and distinct protein interactions compared to linear forms.

A Short 63-Nucleotide Element Promotes Efficient circRNA Translation

This study identifies a 63-nucleotide element that promotes efficient circRNA translation, comparable to traditional IRESs, enhancing their therapeutic potential.

CircAge: A Comprehensive Resource for Aging-Associated Circular RNAs Across Species and Tissues

circAge compiles aging-associated circRNA data from 7 species and 21 tissues, identifying 413,378 unique circRNAs and their conservation, interactions, and coding potential.

CircRNA hypomethylation in the human amygdala implicates FKBP5 in alcohol use disorder

The paper identifies circRNA hypomethylation in the human amygdala linked to FKBP5 in alcohol use disorder, with replication in an animal model.

Purifying circular RNA by ultrafiltration

This study demonstrates that ultrafiltration can purify circRNA with 86% purity and 50% yield, outperforming SE-HPLC.

Os-circANK negatively regulates resistance to bacterial blight in rice via Osa-miR398b/OsCSD1/OsCSD2 pathways

The paper identifies Os-circANK as a circRNA that suppresses rice resistance to bacterial blight by sponging Osa-miR398b and modulating OsCSD1/OsCSD2 expression.

Circular RNAs exhibit exceptional stability in the aging brain and serve as reliable age and experience indicators

This study shows circRNAs are highly stable in the aging fly brain and can indicate age and environmental experience.

A functional screen uncovers circular RNAs regulating excitatory synaptogenesis in hippocampal neurons

The paper identifies circRNAs that regulate excitatory synaptogenesis in rat hippocampal neurons by modulating miR-128-3p activity.

Functional landscape of circular RNAs in human cancer cells

The paper identifies essential circRNAs in human cancer cells and introduces FunCirc, a database of functional circRNAs across cancer cell lines and tissues.

Loss of age-accumulated crh-1 circRNAs ameliorate amyloid β-induced toxicity in a C. elegans model for Alzheimers disease

The paper shows that loss of age-accumulated circ-crh-1 circRNAs reduces Aβ-induced toxicity in C. elegans, suggesting a protective role against Alzheimer's disease.

Circular RNA profiling and functional screening in breast cancer identify circNSD1 as a suppressor of tumor autophagy

The paper identifies circNSD1 as a tumor suppressor in breast cancer that inhibits autophagy and oxidative stress tolerance.

CircPVT1 sponges miR-33a-5p unleashing the c-MYC/GLS1 metabolic axis in breast cancer

This study identifies circPVT1 as a regulator of metabolic pathways in breast cancer by sponging miR-33a-5p, leading to increased c-MYC and GLS1 activity and promoting tumorigenesis.

Species-specific circular RNA circDS-1 enhances adaptive evolution in Talaromyces marneffei through regulation of dimorphic transition and virulence

This study identifies circDS-1, a circular RNA in Talaromyces marneffei, that promotes dimorphic transition and virulence, revealing a novel mechanism for fungal thermal adaptation.

Mitigating Cellular Dysfunction by Addressing Contaminants in Synthetic circRNA

This study identifies contaminants affecting circRNA functionality and develops a purification method to enhance its yield and reduce immune activation.

Bibliometric Analysis of Circular RNA Cancer Vaccines and Their Emerging Impact

This study uses bibliometric analysis to explore circRNA cancer vaccines, identifying research trends and comparing them with mRNA vaccines.

Transcriptome-wide analysis of circRNA and RBP profiles and their molecular and clinical relevance for GBM

The paper analyzes circRNA and RBP expression in GBM to identify their interactions and clinical relevance as stratification markers.

The circular RNA landscape of human dorsal root ganglia and its association with opioid exposure

The paper examines circRNA expression in human dorsal root ganglia (hDRG) under opioid exposure and identifies differentially expressed circRNAs and their potential regulatory roles in pain pathways.

EasyCircR:Detection and reconstruction of circular RNAs post-transcriptional regulatory interaction networks

EasyCircR detects and reconstructs circRNA-miRNA-mRNA regulatory networks through post-transcriptional analysis and visualization.

Circular RNA Circ-Cdr1as modulates Macrophage phenotype and Cardiac Reparative Function by Circ-Cdr1as-miR-7-Klf4 pathway

This study shows circ-Cdr1as modulates macrophage phenotype and cardiac repair via the circ-Cdr1as-miR-7-Klf4 pathway, improving cardiac function post-myocardial infarction.

Extending scope and power of circular RNA researchwith circtools 2.0

The paper introduces circtools 2.0, an enhanced software for circRNA detection and analysis, with new features for improved detection, probe design, conservation analysis, and support for Oxford Nanopore sequencing.

An oligo walk to identify siRNAs against the circular Tau 12->7 RNA

The paper identifies an siRNA effective against a modified circRNA, showing it can be targeted but with variable efficacy.

ca-circSCN8A promotes HPASMCs ferroptosis via LLPS initiated R-Loop

This study identifies ca-circSCN8A as a promoter of ferroptosis in HPASMCs under hypoxia by forming R-loops via LLPS of ca-circSCN8A/FUS/EP300, disrupting redox balance and contributing to pulmonary hypertension.

A poly(A) polymerase and oligo(dT)-dependent method for the purification of engineering circular RNAs that enhances protein expression in eukaryotic cells

This paper introduces a method using poly(A) polymerase and oligo(dT) chromatography to purify engineered circular RNA, improving its purity and enabling enhanced protein expression in eukaryotic cells.