Cancer, Lipids, and Metabolism

IL-4 Licenses B Cell Activation Through Cholesterol Synthesis

This study shows IL-4 promotes B cell activation by upregulating cholesterol synthesis, which is essential for ER expansion, cell cycle progression, and proliferation during influenza infection.

Identification of Fasnall as a therapeutically effective Complex I inhibitor

This study identifies Fasnall as a Complex I inhibitor that mimics FASN inhibition, showing anti-tumor effects without neurological side effects.

Targeting the sphingolipid rheostat in IDH1mut glioma alters cholesterol homeostasis and triggers apoptosis via membrane degradation

This study shows that altering sphingosine levels in IDH1mut glioma cells disrupts cholesterol homeostasis, leading to apoptosis through effects on cholesterol synthesis, uptake, and efflux.

DMT1 contributes to MF- 438 - mediated inhibition of glioma cells

The paper shows MF-438 inhibits glioma growth through both SCD1-dependent lipid metabolism disruption and SCD1-independent DMT1 suppression.

Identification of MYC synthetic lethal genes and networks

The paper identifies synthetic lethal genes and networks for MYC overexpression using CRISPR and shRNA screens, finding that disrupting citrate production and transport inhibits MYC-driven tumor growth.

Proteolytic activation of fatty acid synthase signals pan-stress resolution

The paper shows proteolytic cleavage of fatty acid synthase (FASN) activates a global signal for stress resolution, promoting an anti-inflammatory profile and down-regulating stress-responsiveness.

Nucleoside Diphosphate Kinases 1 and 2 regulate a protective liver response to a high-fat diet

This study shows that NME1/2 regulate liver response to high-fat diet by repressing de novo lipogenesis and activating protective gene expression through histone acetylation.

Triggering blood-lipid-profile by immunomodulatory and antimicrobial molecules for cross-evaluation of early detection of cancer

The paper investigates the impact of immunomodulatory and antimicrobial molecules on blood lipid profiles to explore their potential for early cancer detection.

Role of acetoacetyl-CoA synthetase in glucose uptake by HepG2 cells

This study investigates the role of AACS in glucose uptake and cell proliferation in HepG2 cells, finding that AACS knockdown reduces glucose uptake and increases ketone body concentration, enhancing sensitivity to sorafenib.

Hypoxia truncates and constitutively activates the key cholesterol synthesis enzyme squalene monooxygenase

The paper shows hypoxia triggers truncation and constitutive activation of squalene monooxygenase (SM) through proteasomal targeting and substrate accumulation, linking it to oncogenic properties in endometrial cancer.

Paradoxical activation of SREBP1c and de novo lipogenesis by hepatocyte-selective ACLY depletion in obese mice.

The paper shows that ACLY depletion in obese mice paradoxically increases de novo lipogenesis despite reducing AcCoA levels, linked to increased SREBP1c expression.

Acetyl-CoA mediated autoacetylation of fatty acid synthase in de novo lipogenesis

The paper identifies acetyl-CoA-mediated autoacetylation of FASN at K813 as a regulatory mechanism for de novo lipogenesis in Drosophila larvae.

Overexpression of ELOVL6 has been associated with poor prognosis in patients with head and neck squamous cell carcinoma

This study shows that ELOVL6 overexpression in HNSCC is linked to poor prognosis and affects fatty acid metabolism pathways.

Discovery of novel putative tumor suppressors from CRISPR screens reveals rewired lipid metabolism in AML cells

The paper identifies novel tumor suppressors from CRISPR screens and reveals rewired lipid metabolism in AML cells through functional analysis of gene modules.

Systematic mapping of genetic interactions for de novo fatty acid synthesis

This study maps genetic interactions in FASN-deficient cells to identify genes involved in lipid uptake and metabolic adaptation.

Biomarker identification for statin sensitivity of cancer cell lines

The paper identifies a gene expression signature for statin sensitivity using transcriptome data from cancer cell lines and validates it experimentally, extending it to TCGA tumors and predicting synergistic drug combinations.