Cancer, Lipids, and Metabolism

Adipocytes in tumour microenvironment promote chemoresistance in TNBC through oxysterols

This study shows adipocytes in the tumor microenvironment promote chemoresistance in TNBC by secreting oxysterols that activate the LXR pathway and increase P-glycoprotein expression.

A nuclear branched-chain amino acid catabolism pathway controls histone propionylation in pancreatic cancer

This study identifies a nuclear branched-chain amino acid catabolism pathway in pancreatic cancer that regulates histone propionylation and gene expression.

PCSK9 dependent cholesterol acquisition and utilization underlies metastatic organ preference in pancreatic cancer.

This study identifies PCSK9 as a key determinant of metastatic organ preference in pancreatic cancer by regulating cholesterol acquisition and utilization in liver versus lung environments.

Integrated proteome and lipidome analyses place OCIAD1 at mitochondria-peroxisome intersection balancing lipid metabolism

The paper uses proteomics and lipidomics to show OCIAD1 balances mitochondrial and peroxisomal lipid metabolism by affecting lipid composition and key enzymes.

Targeting SCD triggers lipotoxicity of cancer cells and enhances anti-tumor immunity in breast cancer brain metastasis mouse models

This study shows that inhibiting SCD in breast cancer brain metastases induces lipotoxicity and enhances anti-tumor immunity, improving survival in mouse models.

Jerusalem artichoke extracts regulate the gene expression of key enzymes involved in fatty acid biosynthesis

This study shows that Jerusalem artichoke extracts reduce FASN and ACACA expression, which are key enzymes in fatty acid biosynthesis, and links this effect to topoisomerase II activity.

Expression Profiles of FABP4 and FABP5 in Breast Cancer: Clinical Implications and Perspectives

This study examines FABP4 and FABP5 expression in breast cancer tissues, finding distinct roles in tumor progression and suggesting their potential as prognostic markers and therapeutic targets.

Microenvironmental arginine restriction sensitizes pancreatic cancers to polyunsaturated fatty acids by suppression of lipid synthesis

The paper shows that arginine restriction in the tumor microenvironment limits lipid synthesis in pancreatic cancers, making them susceptible to polyunsaturated fatty acids via ferroptosis.

Lipid metabolic reprogramming drives triglyceride storage and variable sensitivity to FASN inhibition in endocrine-resistant breast cancer cells

This study identifies lipid metabolic reprogramming in endocrine-resistant breast cancer cells, showing TVB-2640 reduces lipid storage but not cell growth.

ELOVL6 as a Therapeutic Target: Disrupting c-MYC-Driven Lipid Metabolism to Enhance Chemotherapy in Pancreatic Cancer

This study identifies ELOVL6 as a therapeutic target in pancreatic cancer by showing its role in c-MYC-driven lipid metabolism and its impact on chemotherapy efficacy.

Defined media reveals the essential role of lipid scavenging to support cancer cell proliferation

This study identifies the metabolic role of serum in cell culture by showing that albumin-bound lipids are essential for cancer cell proliferation and can replace fetal bovine serum.

Palmitate-induced mitochondrial damage restricts histone acetylation in CD8+ T cells to impair anti-tumor immunity.

This study shows that palmitate impairs CD8+ T cell function by damaging mitochondria and reducing histone acetylation, leading to weakened anti-tumor immunity.

Regulation of Age-Related Lipid Metabolism in Ovarian Cancer

This study investigates how aging affects ovarian cancer progression by analyzing gene expression, lipid metabolism, and immune cell changes in rat models, finding that aged adipose microenvironment promotes tumor growth.

P-cadherin mechanoactivates tumor- mesothelium metabolic coupling to promote ovarian cancer metastasis

This study shows that P-cadherin-mediated mechanical forces on mesothelial cells enhance lipid production in ovarian cancer cells, promoting metastasis through lactate-driven lipogenesis.

Statins inhibit onco-dimerization of the 4Ig isoform of B7-H3

This study identifies statins as inhibitors of 4Ig-B7-H3 dimerization, linking their anti-cancer effects to immune checkpoint disruption in B7-H3-expressing tumors.

Targeting de novo lipogenesis improves gemcitabine efficacy in pancreatic ductal adenocarcinoma

This study identifies de novo lipogenesis as a mechanism of gemcitabine resistance in PDAC and shows that targeting lipid synthesis enzymes enhances treatment efficacy.

Poly-unsaturated Fatty Acids from Thamnidium elegans and Mortierella alpina Suppress Prostate Cancer Cells Proliferation and Migration

This study shows that fatty acid lithium salts from Thamnidium elegans and Mortierella alpina inhibit prostate cancer cell proliferation and migration.

The Kinetics of Carbon-Carbon-Bond Formation in Metazoan Fatty Acid Synthase and its Impact on Product Fidelity

The paper investigates the kinetics of carbon-carbon bond formation in fatty acid synthase, revealing how the enzyme's activity and fidelity are influenced by substrate length and dimeric cooperativity.

Chemotherapy resistance due to epithelial-to-mesenchymal transition is caused by abnormal lipid metabolic balance

The paper identifies that Snail-induced chemoresistance in cancer cells is linked to an imbalance in lipid metabolism, specifically through the repression of sphingomyelin biosynthesis and upregulation of ABCA1.

Retinoid X Receptor Signaling Mediates Cancer Cell Lipid Metabolism in the Leptomeninges

This study identifies RXR signaling as a mediator of lipid metabolism in leptomeningeal metastatic cancer cells, revealing a potential therapeutic target.

Filament structures unveil the dynamic organization of human acetyl-CoA carboxylase

The paper determines cryo-EM structures of human ACC1 in inactive and activated states, revealing structural dynamics and regulatory mechanisms.

Myoglobin Inhibits Breast Cancer Cell Fatty Acid Oxidation and Migration via Heme-Dependent Oxidant Production and Not Fatty Acid Binding

FABP4-mediated lipid accumulation and lipolysis in tumor associated macrophages promote breast cancer metastasis

This study shows that FABP4 in tumor-associated macrophages promotes breast cancer metastasis by mediating lipid accumulation and lipolysis in response to unsaturated fatty acids.

Acetate drives ovarian cancer quiescence via ACSS2-mediated acetyl-CoA production

This study shows that ACSS2-mediated acetate conversion to acetyl-CoA promotes quiescence in ovarian cancer cells, linking metabolic reprogramming to therapeutic resistance.

Statins attenuate Wnt/β-catenin signaling by targeting SATB family proteins in colorectal cancer

This study shows statins target SATB family proteins in the Wnt/β-catenin pathway, altering their expression and supporting their potential as anti-cancer agents in colorectal cancer.

Dysregulated Cholesterol Metabolism with Anomalous PI3K/Akt/mTOR pathway Predicts Poor Carboplatin Response in High Grade Serous Ovarian Cancer

A comprehensive analysis of the potential biological functions and prognostic values of SREBF1 for multiple cancer types including colorectal cancer

This study investigates SREBF1's role in multiple cancers, finding it correlates with prognosis and immune infiltration, and affects cell growth and migration.

Activation of the mevalonate pathway in response to anti-cancer treatments drives glioblastoma recurrences through activation of Rac-1

This study shows that activation of the mevalonate pathway and Rac-1 in glioblastoma cells after anti-cancer treatments promotes recurrence, and statins combined with radiation improve survival in mouse models.

In vivo CRISPR screening identifies geranylgeranyl diphosphate as a pancreatic cancer tumor growth dependency

The paper identifies geranylgeranyl diphosphate as essential for pancreatic cancer growth through in vivo CRISPR screening and shows that targeting its synthesis reduces tumor burden.

In Vivo Simvastatin and Brain Radiation in a Model of HER2+ Inflammatory Breast Cancer Brain Metastasis

This study examines if simvastatin and whole-brain radiation affect HER2+ inflammatory breast cancer brain metastases in a mouse model, finding mixed effects on micrometastases but not macrometastases.