D. Li

PROTAC-mediated selective degradation of cytosolic soluble epoxide hydrolase enhances ER-stress reduction

This paper develops first-in-class PROTACs that selectively degrade cytosolic sEH, reducing ER stress more effectively than sEH inhibitors.

Discovery of a SARS-CoV-2 Broadly-Acting Neutralizing Antibody with Activity against Omicron and Omicron + R346K Variants

This paper identifies a broadly neutralizing antibody, STI-9167, effective against SARS-CoV-2 variants including Omicron and Omicron + R346K, and describes its development for clinical trials.

Topological supramolecular network enabled highly conductive and stretchable organic bioelectronics

This paper introduces a topological supramolecular network strategy to create highly conductive and stretchable organic bioelectronics with unprecedented performance in physiological environments.

Single-cell RNA Sequencing Reveals the Temporal Diversity and Dynamics of Cardiac Immunity after Myocardial Infarction

This study uses single-cell RNA sequencing to analyze cardiac immune cell dynamics after myocardial infarction in mice, identifying key immune subsets and their roles in disease progression.

Generation and characterisation of P. falciparum parasites with a G358S mutation in the PfATP4 Na+ pump and clinically relevant levels of resistance to some PfATP4 inhibitors

This paper shows that a G358S mutation in PfATP4 confers clinically relevant resistance to cipargamin and (+)-SJ733 in P. falciparum parasites.

Barley stripe mosaic virus γb protein targets thioredoxin h-type 1 to dampen SA-mediated antiviral defenses

The paper shows that BSMV γb protein targets NbTRXh1 to reduce its reductase activity, impairing SA defense gene expression and enhancing viral movement.

5-aminolevulinic acid-photodynamic therapy ameliorates cutaneous granuloma by killing drug-resistant Mycobacterium marinum

This study shows that ALA-PDT kills drug-resistant M. marinum in vitro and in a mouse model, leading to recovery of cutaneous lesions and clinical improvement in two patients.

Reduced sera neutralization to Omicron SARS-CoV-2 by bothinactivated and protein subunit vaccines and the convalescents

The paper tests neutralization activity of sera from convalescents and vaccine recipients against Omicron, finding that vaccines maintain better neutralization than convalescents.

Cryo-EM structure of an amyloid fibril formed by full-length human SOD1 reveals its pathological conformational conversion

The paper determines the cryo-EM structure of human SOD1 amyloid fibrils, revealing conformational changes associated with ALS pathology.

Circular RNA signatures of human healing and non-healing wounds

This study identifies circRNA expression patterns in healing and non-healing wounds and finds two circRNAs that impair keratinocyte migration while promoting proliferation in non-healing venous ulcers.

Host casein kinase 1-mediated phosphorylation modulates phase separation of a rhabdovirus phosphoprotein and virus infection

This study shows host casein kinase 1 phosphorylates a viral phosphoprotein, altering its phase separation and affecting virus infection.

Different structures and pathologies of alpha-synuclein fibrils derived from preclinical and postmortem patients of Parkinson's disease

This study compares alpha-synuclein fibril structures from preclinical and postmortem Parkinson's disease patients, showing structural and pathological differences in fibril conformation during disease progression.

Camel nanobodies broadly neutralize SARS-CoV-2 variants

The paper isolates two camel nanobodies that broadly neutralize SARS-CoV-2 and its variants, showing therapeutic potential in mice.

Diversity, function and evolution of marine microbe genomes

The paper reviews marine microbiome studies, analyzes 17.59 Tb of sequencing data, and constructs genome and gene catalogues to explore marine prokaryotic diversity and function.

Alkaliphilus flagellata sp. nov., Butyricicoccus intestinisimiae sp. nov., Clostridium mobile sp. nov., Clostridium simiarum sp. nov., Dysosmobacter acutus sp. nov., Paenibacillus brevis sp. nov., Peptoniphilus ovalis sp. nov., and Tissierella simiarum sp. nov., isolated from monkey feces

The paper describes eight novel bacterial species isolated from cynomolgus monkey feces and provides their taxonomic characterization.

A histidine cluster determines YY1-compartmentalized coactivators and chromatin elements in phase-separated super-enhancers

This study shows YY1 forms phase-separated super-enhancers by compartmentalizing coactivators and enhancer elements, with a histidine cluster essential for this process.

The influence of age and sex on the pre-treatment immune microenvironment of a carcinogen induced murine model of bladder cancer

This study examines sex and age-related immune differences in healthy and carcinogen-exposed murine bladders using bulk RNA sequencing and spatial immune profiling.

Legionella pneumophila regulates host cell motility by targeting Phldb2 with a 14-3-3ζ-dependent protease effector

This study identifies Lem8, a protease effector from Legionella pneumophila, which inhibits host cell motility by targeting Phldb2 via 14-3-3ζ-dependent activation.

Genomics-informed insights into microbial degradation of N,N-dimethylformamide

This study identifies genomic diversity and degradation pathways for N,N-dimethylformamide (DMF) by analyzing 20,762 genomes, revealing plasmid-mediated degradation and anaerobic potential for methane production.

Single-shot rAAV5-based Vaccine Provides Long-term Protective Immunity against SARS-CoV-2 and Its Variants

This study develops a single-dose rAAV5-based vaccine that provides long-term immunity against SARS-CoV-2 and its variants with high neutralizing antibody titers and safety.

The creation of functioning gastrojejunostomy following magnetic compression

This study evaluates methods for creating gastrojejunostomy using magnetic compression and pyloric ligation in rabbits, finding that pyloric ligation provides better long-term patency than paclitaxel-loaded magnets.

A novel PD-L1-targeted shark VNAR single domain-based CAR-T strategy for treating breast cancer and liver cancer

This paper develops a PD-L1-targeted shark VNAR-based CAR-T strategy that effectively targets breast and liver cancer cells and reduces tumor metastasis in mice.

Discovery of nanobodies against SARS-CoV-2 and an uncommon neutralizing mechanism

This study isolates and characterizes two nanobodies against SARS-CoV-2 that neutralize the virus through distinct mechanisms, with one showing efficacy against the Alpha variant and reduced activity against the Beta variant.

Neutralization of recombinant RBD-subunit vaccine ZF2001-elicited antisera to SARS-CoV-2 variants including Delta

This study evaluates the neutralizing activity of ZF2001 vaccine-elicited antisera against SARS-CoV-2 variants, finding that E484K/Q mutations reduce neutralization and that extended intervals between doses improve variant resilience.

Oxidative phosphorylation safeguards pluripotency via UDP-N-acetylglucosamine

This paper shows that oxidative phosphorylation (OXPHOS) generates most ATP in mouse ESCs and is essential for pluripotency by coupling with the hexosamine biosynthesis pathway to produce UDP-GlcNAc.

Antibody Cocktail Exhibits Broad Neutralization against SARS-CoV-2 and SARS-CoV-2 variants

This study identifies two antibodies, F61 and H121, that neutralize SARS-CoV-2 and its variants, including B.1.1.7 and B.1.351, by targeting distinct epitopes on the RBD.

The phosphatidylglycerol phosphate synthase PgsA utilizes a trifurcated amphipathic cavity for catalysis at the membrane-cytosol interface

This study reports the structures of S. aureus PgsA at two catalytic states, revealing the mechanism of phosphatidylglycerol biosynthesis and the impact of daptomycin resistance mutations.

Natural variation in GmRAV confers ecological adaptation through photoperiod control of flowering time and maturity in soybean

A broadly neutralizing antibody protects against SARS-CoV, pre-emergent bat CoVs, and SARS-CoV-2 variants in mice

A broadly neutralizing antibody protects against multiple SARS-CoV and SARS-CoV-2 variants in mice by targeting a conserved epitope in the receptor-binding domain.

Broadly-reactive IgG responses to heterologous H5 prime-boost influenza vaccination are shaped by antigenic relatedness to priming strains

The paper examines how prior H5 exposure influences IgG responses to H5 vaccination, finding that antibody breadth and strength correlate with antigenic distance to priming strains.