J. Cui

The jasmine (Jasminum sambac) genome and flower fragrances

This study presents the first de novo genome of Jasminum sambac and identifies gene clusters and pathways involved in flower fragrance biosynthesis.

Calmodulin acts as a state-dependent switch to control a cardiac potassium channel opening

The paper shows CaM-VSD interactions act as a state-dependent switch to control KCNQ1 pore opening by modulating PIP2 binding and VSD-pore coupling.

E-cadherin interacts with EGFR resulting in hyper-activation of ERK in multiple models of breast cancer

This study shows E-cadherin interacts with EGFR to hyper-activate ERK, promoting proliferation in breast cancer models and identifying a potential therapeutic target.

Identify potent SARS-CoV-2 main protease inhibitors via accelerated free energy perturbation-based virtual screening of existing drugs

This paper identifies potent SARS-CoV-2 main protease inhibitors using accelerated free energy perturbation-based virtual screening of existing drugs, finding 15 inhibitors from 25 predicted drugs.

RANKL from Bone Marrow Adipocytes Regulates Osteoclast Formation and Bone Loss in Mice

This study shows that RANKL from bone marrow adipocytes regulates trabecular osteoclast formation and bone loss in mice, with implications for therapeutic targeting of bone marrow adiposity.

Characterization of a novel gene, srpA, conferring resistance to streptogramin A, pleuromutilins, and lincosamides in Streptococcus suis

This study identifies a novel gene, srpA, in Streptococcus suis that confers resistance to multiple ribosome-targeting antibiotics by altering ribosome binding.

The biphasic and age-dependent impact of Klotho on hallmarks of aging and skeletal muscle function

This study uses a statistical physics approach to assess aging-related entropy in skeletal muscle and shows that Klotho overexpression improves muscle function in older mice but not beyond a certain age threshold.

Antifibrotic activity of a rho-kinase inhibitor restores outflow function and intraocular pressure homeostasis

This study shows that netarsudil, a rho-kinase inhibitor, reverses glucocorticoid-induced ocular hypertension by reducing fibrosis and restoring outflow function.

Deficient uracil base excision repair leads to persistent dUMP in HIV proviruses during infection of monocytes and macrophages

This study shows that monocytes lack functional uracil base excision repair, leading to persistent dUMP in HIV proviruses, while macrophages have limited hUNG2 activity, affecting viral infectivity and diversification.

Extracellular histones trigger disseminated intravascular coagulation by lytic cell death

The paper shows extracellular histones cause disseminated intravascular coagulation (DIC) via tissue factor-dependent lytic cell death, independent of inflammasome or TLR pathways.

Unique Evolution of Antiviral Tetherin in Bats

This study characterizes the evolution of tetherin in bats, identifying unique structural variants and splice isoforms with antiviral functions.

Orthogonal genome-wide screenings in bat cells identify MTHFD1 as a target of broad antiviral therapy

The paper identifies MTHFD1 as a target for broad antiviral therapy by screening bat cells with RNAi and CRISPR libraries against mumps and influenza viruses.

Nonspecific membrane interactions can modulate BK channel activation

This study shows that the C-linker in BK channels modulates activation through nonspecific membrane interactions, challenging previous assumptions about its role.

mTORC2 mediate FLCN-induced HIF2α nuclear import and proliferation of clear cell renal cell carcinoma

Developmental plasticity of hearing sensitivity in red-eared slider Trachemys scripta elegans

This study examines how hearing sensitivity changes with age in red-eared slider turtles, finding frequency-specific developmental patterns and age-related shifts in auditory thresholds.

Identification and evolution of avian endogenous foamy viruses

The paper identifies endogenous foamy viruses in two stork species, showing independent integration events in birds and expanding the known taxonomic distribution of foamy viruses.

Two-stage electro-mechanical coupling of a Kv channel in voltage-dependent activation

The paper identifies a two-stage electro-mechanical coupling mechanism in KV7.1 channels, where VSD transitions through intermediate and activated states to trigger pore opening.

ML277 specifically enhances pore opening of KCNQ1 with VSD at the activated state by modulating VSD-pore coupling

This study shows ML277 enhances the AO state of KCNQ1 channels by improving VSD-pore coupling, offering a potential therapy for long QT syndrome.

Understanding the Mechanistic Contribution of Herbal Extracts in Compound Kushen Injection with Transcriptome Analysis

This study uses transcriptome analysis to investigate how two herbal extracts in Compound Kushen Injection interact, showing Kushen drives cytotoxicity and Baituling enhances it while activating immune pathways.

A new strategy for identifying mechanisms of drug-drug interaction using transcriptome analysis: Compound Kushen injection as a proof of principle

This paper introduces a transcriptome analysis workflow to study drug-drug interactions, using Compound Kushen Injection and chemotherapy drugs as a proof of principle, identifying MYD88 as a key regulator.

Co-allocation Action of Azospirillum brasilense Inoculation and Seed Priming for Improving Germination and Seedling Growth in Aged Grass Seeds

This study combines Azospirillum brasilense inoculation with seed priming to enhance germination and seedling growth in aged grass seeds, finding that H2O2 priming with optimal bacterial concentration and time is most effective.

The Effect of Compound Kushen Injection on Cancer Cells: Integrated Identification of Candidate Molecular Mechanisms.

This study identifies candidate molecular mechanisms of Compound Kushen Injection by analyzing transcriptome changes in cancer cells and linking them to gene expression and pathway alterations.

Effect of Compound Kushen Injection, a natural compound mixture, and its identified chemical components on migration and invasion of colon, brain and breast cancer cell lines

This study evaluates the effects of Compound Kushen Injection and its components on cancer cell migration and invasion in multiple cell lines, finding reduced motility and invasiveness.

Genomic insights into evolutionary journey of the porcine endogenous retroviruses

The paper uses genomic mining to uncover the evolutionary history of porcine endogenous retroviruses (PERVs), revealing their origins and cross-species transmission events.

Fractional Deletion Of Compound Kushen Injection, A Natural Compound Mixture, Indicates Cytokine Signaling Pathways Are Critical For Its Perturbation Of The Cell Cycle.

This study identifies critical compounds in Compound Kushen Injection (CKI) that modulate cell cycle and apoptosis through cytokine signaling pathways.

A Reptilian Endogenous Foamy Virus Sheds Light on the Early Evolution of Retroviruses

The paper discovers a new endogenous foamy virus in tuatara, showing co-divergence with its host and filling a gap in retrovirus evolution.

Cell Cycle, Energy Metabolism and DNA Repair Pathways in Cancer Cells are Suppressed by Compound Kushen Injection.

This study shows that Compound Kushen Injection suppresses cell cycle, DNA repair, and energy metabolism in cancer cells, while its major component oxymatrine has limited effects.

Adiposity-Independent Effects of Aging on Insulin Sensitivity and Clearance in Humans and Mice

This study shows aging impairs insulin sensitivity independently of adiposity in mice and humans, suggesting distinct mechanisms from obesity-related insulin resistance.