L. Chen

High-sensitivity whole-genome recovery of single viral species in environmental samples

This paper develops a method to recover complete viral genomes from environmental samples with high sensitivity, achieving 100% recovery of a spiked-in virus and 99.4% for a larger virus.

Activation of glucocorticoid receptor signaling inhibits KSHV-induced inflammation and tumorigenesis

This study shows that dexamethasone inhibits KSHV-induced inflammation and tumorigenesis by activating GR signaling, which suppresses IL-1 and induces IL-1Ra.

The in vitro functional profiles of fentanyl and nitazene analogs at the μ-opioid receptor - high efficacy is dangerous regardless of signaling bias

This study evaluates the in vitro functional profiles of fentanyl and nitazene analogs at the μ-opioid receptor, finding that high intrinsic efficacy in Gi signaling correlates with increased risk of intoxication, regardless of signaling bias.

Pan-genome analysis of different morphotypes reveals genomic basis of Brassica oleracea domestication and differential organogenesis

This study constructs a pan-genome of Brassica oleracea to uncover genomic basis of domestication and organogenesis differences among morphotypes.

Quantitative dynamics of intracellular NMN by genetically encoded biosensor

This study develops a genetically encoded biosensor to measure intracellular NMN dynamics in live cells and identifies Slc25a45 as a potential mitochondrial NMN transporter.

Virological characteristics of the SARS-CoV-2 Omicron EG.5.1 variant

The paper investigates the virological features of the SARS-CoV-2 EG.5.1 variant, finding its fitness and antiviral sensitivity comparable to XBB.1.5, with structural differences in spike proteins.

Dual Ethanolamine Head Groups in Ionizable Lipids Facilitate Phospholipid-free Stable Nanoparticle Formulation for Augmented and Safer mRNA Delivery

This paper introduces ionizable lipids with dual ethanolamine head groups for phospholipid-free mRNA delivery, showing improved stability, efficiency, and reduced toxicity.

Antibodies utilizing VL6-57 light chains target a convergent cryptic epitope on SARS-CoV-2 spike protein driving the genesis of Omicron variants

The paper identifies public antibodies using VL6-57 light chains that target a conserved epitope on SARS-CoV-2 spike protein, showing how Omicron variants evolved to escape these antibodies.

Identification and characterization of a beta-1,4 Galactosidase from Elizabethkingia meningoseptica and its application on living cell surface

This study identifies and characterizes a beta-1,4 galactosidase from Elizabethkingia meningoseptica that can remove galactose from living cell surfaces, named geGalaseI.

Maturation and detoxification of synphilin-1 inclusion bodies regulated by sphingolipids

The paper identifies sphingolipids as regulators of synphilin-1 inclusion body maturation and detoxification in yeast and mammalian cells.

Gut microbial genomes with paired isolates from China signify probiotic and cardiometabolic effects

The paper presents a new microbial reference set with paired isolates from China, showing probiotic and cardiometabolic effects on hosts.

Quantitative monitoring of neuronal regeneration by functional assay and wireless neural recording

This study uses wireless neural recording to monitor neuronal regeneration in mice after traumatic brain injury, finding that FCCP treatment correlates with recovery of evoked local field potentials.

Reduced glutamate decarboxylase 1 underlies morphine-promoted lung metastasis of triple-negative breast cancer in mice

This study shows that long-term morphine use in mice increases lung metastasis of triple-negative breast cancer by reducing GAD1 and taurine biosynthesis, suggesting taurine may counteract this effect.

SARS-CoV-2 Omicron infection augments the magnitude and durability of systemic and mucosal immunity in triple-dose CoronaVac recipients

This study examines immune responses in CoronaVac-vaccinated individuals after Omicron infection, showing enhanced antibody and cellular immunity compared to unvaccinated controls.

Adeno-to-squamous transition drives resistance to KRAS inhibition in LKB1 mutant lung cancer

The paper identifies adeno-to-squamous transition (AST) as a mechanism of resistance to KRAS inhibitors in LKB1 mutant lung cancer and links KRT6A expression to poor patient outcomes.

Hsa_circ_0005397 could promote hepatocellular carcinoma progression and metastasis through EIF4A3

This study identifies hsa_circ_0005397 as a promoter of hepatocellular carcinoma progression and metastasis via EIF4A3, showing its diagnostic and prognostic significance.

Mechano-signaling of prostate tumor initiating cells facilitates their tropism to stiff metastatic niche

The paper shows that mechanotransduction via TAZ and cytoskeletal tension promotes prostate cancer stem cell metastasis and identifies a YAP/TAZ inhibitor as a potential therapeutic target.

Rationally designed multimeric nanovaccines using icosahedral DNA origami for molecularly controlled display of SARS-CoV-2 receptor binding domain

This study designs multimeric nanovaccines using icosahedral DNA origami to display SARS-CoV-2 RBD, showing enhanced B cell activation and immune responses in mice.

Epstein-Barr virus BRRF1 induces butyrophilin 2A1 in nasopharyngeal carcinoma cells via the IL-22/JAK3-STAT3 pathway

This study shows Epstein-Barr virus BRRF1 induces BTN2A1 in nasopharyngeal carcinoma cells through the IL-22/JAK3-STAT3 pathway, enhancing Vγ9Vδ2 T cell anti-tumor activity.

Simultaneous targeting of AMPK and mTOR is a novel therapeutic strategy against prostate cancer

This study shows that targeting both AMPK and mTOR can inhibit prostate cancer metastasis by blocking the metabolic switch required for tumor growth in new environments.

Infant gut bacteriophage strain persistence during the first three years of life

The paper investigates phage succession in infants over three years, finding that 9% of early phage colonizers persist, with maternal transmission and stop codon reassignment playing key roles.

On Casein Kinase-2 (CK2) deregulation in NSCLC: an enzyme subunit-centered approach

This study investigates CK2 subunit deregulation in NSCLC using multiomics data and IHC, finding that CSNK2A1 and CSNK2B upregulation correlates with poor prognosis and tumor progression.

Functional dissection of KATP channel structures reveals the importance of a conserved interface

This study identifies a conserved interface in KATP channels critical for Mg-ADP activation through mutagenesis experiments and structural analysis.

Methanotrophic Methanoperedens archaea host diverse and interacting extrachromosomal elements

The paper identifies and characterizes diverse extrachromosomal elements in Methanoperedens archaea, including mini-Borgs and viruses, and shows their genetic exchange and potential impact on archaeal activity.

Collagenesis Orchestrates Mechanoadaptive Homeostasis of Intervertebral Disc

The paper identifies a novel mechanoadaptive process in intervertebral discs through collagenesis, revealing TRPV4's role in collagen II synthesis and mechanical stress adaptation.

The distinct roles of MSH2 and MLH1 in basal-like breast cancer and immune modulation

This study identifies distinct roles of MSH2 and MLH1 in basal-like breast cancer, showing MSH2 promotes metastasis while MLH1 enhances it, and reveals MSH2's role in immune modulation through IFNAR1 regulation.

The super-pangenome of Populus unveil genomic facets for adaptation and diversification in widespread forest trees

The paper constructs a super-pangenome of 19 Populus species to explore genomic factors driving adaptation and diversification in forest trees.

Mesophyll-specific overexpressing of SvHXK6 gene improves water use efficiency without yield loss in C4 Setaria viridis

This study overexpresses SvHXK6 in mesophyll cells of C4 Setaria viridis, improving water use efficiency without reducing biomass or yield.

Comprehensive Characterization and Global Transcriptome Analyses of Human Fetal Liver Terminal Erythropoiesis

This study characterizes human fetal liver terminal erythropoiesis through RNA sequencing of primary and cultured erythroblasts and immortalized cell lines, revealing gene expression patterns and pathway changes associated with enucleation.

The novel nematicide chiricanine A suppresses Bursaphelenchus xylophilus pathogenicity in Pinus massoniana by inhibiting Aspergillus and its secondary metabolite, sterigmatocystin