L. Chen

Shin in the eye: Au-CS@FNDs as contact lens additives for blocking UV irradiation, bacterial keratitis, and corneal neovascularizationtherapies

This paper develops Au-CS@FNDs contact lens additives to block UV, prevent bacterial keratitis, and inhibit corneal neovascularization.

COMBINATION THERAPIES TARGETING ALK-ABERRANT NEUROBLASTOMA IN PRECLINICAL MODELS.

This study evaluates lorlatinib, an ALK inhibitor, in combination with chemotherapy or idasanutlin in preclinical neuroblastoma models, finding synergy in models with high ALK expression.

Temporal colonization of the gut microbiome in neonatal Bos taurus at single nucleotide resolution

This study tracks microbial colonization in neonatal calves and identifies genetic links between microbes and host metabolites affecting health and growth.

Early microbial intervention reduces diarrhea while improves later milk production in newborn calves

This study shows that early microbial intervention in newborn calves reduces diarrhea and improves later milk production by altering gut microbiome composition and metabolite profiles.

Two haplotype-resolved genomes of highly heterozygous AAB allotriploid bananas provide insights into subgenome asymmetric evolution and banana wilt control

This study presents haplotype-resolved genomes of triploid bananas, revealing subgenome asymmetric evolution and resistance mechanisms against banana wilt.

Artificially cultivated duckweed: a high-efficiency starch producer

This paper reports a method to produce starch efficiently from duckweed under specific conditions and identifies mechanisms behind its high starch accumulation.

Duckweed evolution: from land back to water

This study investigates the reverse evolution of duckweed from land back to water, showing gradual degeneration in root structure, stomatal function, and lignocellulose content, along with gene pathway changes.

COMT inhibitor tolcapone represses the migration and invasion of trophoblast and results in preeclampsia-like phenotypes in mice

This study shows that tolcapone causes embryo lethality and preeclampsia-like phenotypes in mice by inhibiting trophoblast migration and invasion.

Adaptive-learning physics-aware light-field microscopy enables day-long and millisecond-scale super-resolution imaging of 3D subcellular dynamics

This paper introduces Alpha-LFM, a physics-aware deep learning framework for 3D super-resolution imaging of living cells, achieving high resolution, speed, and low phototoxicity over long periods.

N6-methyladenosine (m6A) and reader protein YTHDF2 enhance innate immune response by mediating DUSP1 mRNA degradation and activating mitogen-activated protein kinases during bacterial and viral infections

The paper shows that m6A and YTHDF2 regulate DUSP1 to enhance innate immune response during infections by promoting DUSP1 degradation and activating MAPKs.

Spatial transcriptomic atlas of shoot organogenesis in tomato callus

This study creates a spatial transcriptomic atlas of tomato callus during shoot regeneration, identifying cell types and developmental trajectories.

Design, evaluation and implementation of synthetic isopentyldiol pathways in Escherichia coli

The paper designs and evaluates synthetic isopentyldiol pathways in E. coli, finding that a computationally designed pathway produces IPDO at 2.2 mg/L from glucose.

Augmentation of Histone Deacetylase 6 Activity Impairs Mitochondrial Respiratory Complex I in Ischemic/Reperfused Diabetic Hearts

This study shows that increasing HDAC6 activity impairs mitochondrial complex I in diabetic hearts subjected to ischemia/reperfusion, and that inhibiting HDAC6 improves cardiac function.

Structural basis for lysophosphatidylserine recognition by GPR34

This study presents cryo-EM structures of GPR34-Gi complex bound with LysoPS analogs, revealing ligand recognition mechanisms and identifying 2-acyl LysoPS as the physiological ligand.

Exceeding 80% efficiency of single-bead encapsulation in microdroplets through hydrogel coating-assisted close-packed ordering

This paper introduces a hydrogel coating method to improve single-bead encapsulation efficiency in microdroplets to over 80%.

Two teosintes made modern maize

This study clarifies the origin of modern maize by showing it resulted from an ancient admixture between domesticated maize and Zea mays ssp. mexicana around 5300 years ago, contributing to genetic and phenotypic diversity.

EstroGene database reveals diverse temporal, context-dependent and directional estrogen receptor regulomes in breast cancer

The paper establishes the EstroGene database, which compiles 246 experiments from 136 datasets to analyze estrogen receptor regulomes in breast cancer, revealing diverse temporal, context-dependent, and directional responses.

Redefining hematopoietic progenitor cells and reforming the hierarchy of hematopoiesis

This study redefines hematopoietic progenitor cells and reformulates the hematopoiesis hierarchy using a transcriptional atlas, identifying key transcription factors and distinct lineage commitment processes.

Mycobacterium tuberculosis resides in lysosome-poor monocyte-derived lung cells during chronic infection

This study identifies lysosome-poor monocyte-derived lung cells as a niche for Mtb persistence during chronic infection, suggesting a target for host-directed therapy.

TGFB1 Induces Fetal Reprogramming and Enhances Intestinal Regeneration

This study identifies TGFB1 as a key driver of fetal reprogramming and intestinal regeneration, showing its role in enhancing epithelial repair through a YAP-SOX9 transcriptional circuit.

Lipoprotein sorting to the cell surface via a crosstalk between the Lpt and Lol pathways during outer membrane biogenesis

The paper identifies lipoproteins transported to the cell surface via LptDE and reveals a crosstalk between Lpt and Lol pathways in Gram-negative bacteria.

Enhancing detectable fluorescence fluctuation for high-throughput and four-dimensional live-cell super-resolution imaging

This paper introduces SACD, a super-resolution imaging method that reduces acquisition time and improves resolution, enabling high-throughput and 4D live-cell imaging.

An ESCRT grommet cooperates with a diffusion barrier to maintain nuclear integrity

The paper investigates ESCRT-III proteins' roles in maintaining nuclear envelope integrity during mitosis and interphase, revealing distinct functions of CHMP7/Cmp7 and a diffusion barrier.

Persistent gene flow suggests an absence of reproductive isolation in an African antelope speciation model

The paper sequenced waterbuck genomes to study speciation, finding historical gene flow across a Rift Valley barrier and no reproductive isolation.

Ring-finger protein 34 facilitates nervous necrosis virus evading antiviral innate immunity by targeting TBK1 and IRF3 for ubiquitination and degradation

This paper identifies RNF34 as a viral E3 ubiquitin ligase that suppresses antiviral innate immunity by degrading TBK1 and IRF3, facilitating NNV replication.

Quantitatively mapping local quality of super-resolution microscopy by rolling Fourier ring correlation

This paper introduces a method to quantitatively map the local quality of super-resolution microscopy images, enabling better integration of reconstructions and detection of uncertainties.

Structural and Computational Design of a SARS-CoV-2 Spike Antigen with Increased Receptor Binding Domain Exposure and Improved Immunogenicity

This study designs a modified SARS-CoV-2 Spike antigen with increased RBD exposure and immunogenicity, showing improved neutralizing antibody responses in mice.

Soft and stretchable organic bioelectronics for continuous intra-operative neurophysiological monitoring during microsurgery

This paper introduces a soft, stretchable organic bioelectronic system for continuous intra-operative neurophysiological monitoring during microsurgery, demonstrating improved signal quality and reduced post-operative complications in animal models.

Host translation machinery is not a barrier to phages that infect both CPR and non-CPR bacteria

The paper identifies phages capable of infecting both CPR and non-CPR bacteria, revealing their ability to use alternative genetic codes and expand host range.

Discovery of benzophenanthridine derivatives with potent activity against multidrug resistant Mycobacterium tuberculosis

This study identifies two benzophenanthridine derivatives with potent anti-Mtb activity, effective against multidrug-resistant strains and comparable to rifampicin.