S. Jiang

A framework for predicting potential host ranges of pathogenic viruses based on receptor ortholog analysis

The paper introduces REPOST, a framework predicting potential virus hosts by analyzing receptor orthologs, achieving 95.74% accuracy for SARS-CoV-2.

Spatially expandable fiber-based probes as a multifunctional deep brain interface

This paper introduces spatially expandable fiber-based probes for deep brain interface, enabling three-dimensional recording and stimulation of neural activity with high resolution and minimal tissue damage.

The Arabidopsis E3 ubiquitin ligase PUB4 regulates BIK1 homeostasis and is targeted by a bacterial type-III effector

This study shows that the bacterial effector RipAC targets PUB4 to inhibit PTI by disrupting BIK1 homeostasis.

Is there a need for preoperative α-blocker in patients missed preoperative diagnosis of extra-adrenal retroperitoneal paraganglioma undergoing paraganglioma resection? A retrospective study of 167 cases at a single center

This study evaluates the impact of preoperative α-blocker use on outcomes in extra-adrenal retroperitoneal paraganglioma surgeries, finding no significant differences in postoperative complications.

Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide

This study evaluates enzalutamide's antiviral efficacy against SARS-CoV-2 in different cell types and mouse models, finding it effective in prostate cancer cells but not in lung cells or organoids.

Long-term survival of salmon-attached SARS-CoV-2 at 4 degree as a potential source of transmission in seafood markets

This study shows that SARS-CoV-2 attached to salmon can remain infectious for over a week at 4°C, indicating a potential transmission risk in seafood markets.

Engineered Trimeric ACE2 Binds and Locks "Three-up" Spike Protein to Potently Inhibit SARS-CoVs and Mutants

This study engineers a trimeric ACE2 protein that binds the spike protein with high affinity, inhibiting SARS-CoVs and mutants by locking the spike in a 'three-up' conformation.

Ontogeny and Vulnerabilities of Drug-Tolerant Persisters in HER2+ Breast Cancer

This study identifies drug-tolerant persisters (DTPs) in HER2+ breast cancer and reveals their origins and vulnerabilities to TKI resistance.

Intracellular accumulation and secretion of hydrophobin-enriched vesicles aid the rapid sporulation of molds

The paper investigates the role of hydrophobin-enriched vesicles in mold sporulation, showing their intracellular accumulation and secretion contribute to spore hydrophobicity and rapid sporulation.

Phosphoproteomics Reveals AMPK Substrate Network in Response to DNA Damage and Histone Acetylation

The paper identifies AMPK substrates and their roles in DNA damage response and histone acetylation through phosphoproteomics and histone modification analysis.

Single-cell screening of SARS-CoV-2 target cells in pets, livestock, poultry and wildlife

The paper screens SARS-CoV-2 target cells across 11 animal species using single-cell transcriptomes, finding higher proportions in cats and detecting them in multiple pig cell types.

Yeast-Expressed SARS-CoV Recombinant Receptor-Binding Domain (RBD219-N1) Formulated with Aluminum Hydroxide Induces Protective Immunity and Reduces Immune Enhancement

This paper develops a SARS-CoV subunit vaccine using yeast-expressed RBD219-N1 with Alhydrogel® and shows it provides full protection against SARS-CoV challenge in mice.

Chromatin 3D interaction analysis of the STARD10 locus unveils FCHSD2 as a new regulator of insulin secretion

The paper identifies FCHSD2 as a new regulator of insulin secretion by analyzing 3D chromatin interactions at the STARD10 locus in human islets.

Fully human single-domain antibodies against SARS-CoV-2

This paper develops fully human single-domain antibodies against SARS-CoV-2 and identifies their neutralizing activity and immunogenic profile compared to SARS-CoV and MERS-CoV.

Inhibition of SARS-CoV-2 infection (previously 2019-nCoV) by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion

This paper identifies EK1C4, a potent fusion inhibitor against SARS-CoV-2 and other coronaviruses, showing high efficacy in vitro and in vivo.

Differential Regulation of Single Microtubules and Bundles by a Three-Protein Module

The paper investigates how a three-protein module differentially regulates single microtubules and bundles, revealing mechanisms that create distinct dynamic properties.

Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody

This study shows that the SARS-CoV-specific antibody CR3022 binds strongly to 2019-nCoV RBD with a KD of 6.3 nM, while other antibodies targeting the ACE2 site fail to bind, highlighting the importance of RBD differences for cross-reactivity.

Augmenting Vascular Disease Diagnosis by Vasculature-awareUnsupervised Learning

This paper introduces VasNet, an unsupervised learning algorithm that improves vascular disease diagnosis from unlabeled images by focusing on retinal vasculature features.

Deep Learning Identifies Cardiomyocyte Nuclei in Murine Tissue with High Precision

The paper develops a deep learning model to identify cardiomyocyte nuclei in mouse heart tissue using image segmentation and immunostaining, achieving high sensitivity and specificity.

NIHBA: A Network Interdiction Approach with Hybrid Benders Algorithm for Strain Design

This paper introduces a hybrid Benders algorithm for strain design using a network interdiction model, achieving efficient and scalable solutions for metabolic network redesign.

The Structural Basis of Indisulam-Mediated Recruitment of RBM39 to the DCAF15-DDB1-DDA1 E3 Ligase Complex

This study determines the structure of the DCAF15-DDB1-DDA1-Indisulam-RBM39 complex, revealing how Indisulam promotes RBM39 degradation via a novel degron motif.

Geomagnetic field absence reduces adult body weight of a migratory insect by disrupting feeding behavior and appetite regulation

This study shows that absence of geomagnetic field reduces feeding in brown planthopper nymphs, leading to lower body weight and altered glucose levels and appetite-related gene expression.

Biodegradable harmonophores for targeted high-resolution in vivo tumor imaging

This paper develops biodegradable harmonophores for targeted high-resolution in vivo tumor imaging in zebrafish embryos.

Prognostic Role of c-Met Overexpression in High Grade Glioma: a Meta-analysis

This study evaluates the prognostic role of c-Met overexpression in high-grade glioma through meta-analysis and finds it correlates with poor progression-free survival but not overall survival.

High-throughput isolation and culture of human gut bacteria with droplet microfluidics

The paper develops a droplet microfluidics platform to isolate and culture human gut bacteria, demonstrating its use in studying metabolic variation and growth kinetics.

Single cell RNA-seq reveals cellular diversity and developmental characteristics of human infant retina

This study uses single-cell RNA-seq to analyze human infant retina, identifying cell types, communication networks, and developmental changes, providing a resource for retinal research and regenerative medicine.

Single cell RNA sequencing reveals cellular diversity of trisomy 21 retina

This study uses single-cell RNA sequencing to analyze the cellular diversity and molecular markers in the retina of a trisomy 21 fetus, revealing communication networks and novel markers.

FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy

This study identifies FAK activity as a driver of platinum resistance in ovarian cancer by sustaining CSC survival and DNA repair, showing that FAK inhibitors combined with platinum can overcome resistance.

FabriEVEs: A dedicated platform for endogenous viral elements in fishes, amphibians, birds, reptiles and invertebrates

FabriEVEs is a database that collects, classifies, and annotates endogenous viral elements in non-mammalian species, enabling comparative analysis and host-virus co-evolution studies.

Vector-Mediated Transport Producing Drug-like Peptides

This paper develops a vector-mediated transport approach to create drug-like peptides with oral activity, blood-brain-barrier transport, and extended in vivo half-life.