X. Jiang

Identification of functional immune and neuronal tumor cells in glioma

The paper introduces SCRAM, a tool that identifies tumor-specific cell types in glioma with functional properties similar to non-tumor cells.

A Model of High-Speed Endovascular Sonothrombolysis with Vortex Ultrasound-Induced Shear Stress to Treat Cerebral Venous Sinus Thrombosis

This paper introduces a vortex ultrasound technique for endovascular sonothrombolysis that significantly improves clot lysis rates in cerebral venous sinus thrombosis.

Integrating Network Pharmacology And Experimental Verification To Explore The Mechanism Of Qionggui Power Against Atherosclerosis

This study uses network pharmacology and in vitro experiments to identify Qionggui Power's active ingredients and mechanisms against atherosclerosis, showing suppression of the NF-κB pathway.

Modelling Membrane Reshaping by Staged Polymerization of ESCRT-III Filaments

The paper models how ESCRT-III filaments reshape membranes through staged polymerization and depolymerization, identifying mechanical conditions for membrane deformation and scission.

Targeting the Hedgehog Signaling Pathway to Improve Tendon-to-Bone Integration

This study shows that stimulating the Hedgehog pathway improves tendon-to-bone integration in mice by enhancing fibrocartilage formation and integration strength.

The patterned assembly and stepwise Vps4-mediated disassembly of composite ESCRT-III polymers drives archaeal cell division

The paper uses super-resolution microscopy and computational modeling to show how CdvB/CdvB1/CdvB2 proteins form a patterned composite ESCRT-III division ring that disassembles stepwise to drive archaeal cell division.

Coarse-scale Optoretinography(CoORG) with extended field-of-view for normative characterization.

This paper introduces CoORG, a non-AO optoretinography system with extended FOV, showing high repeatability and agreement with AO-OCT ORG in healthy subjects.

An Unexpected Single-step Glycosylation Enables the Construction of Antibody-Biomacromolecule Conjugates as Therapeutics

This paper demonstrates a method to efficiently conjugate biomacromolecules to antibodies using modified Fc glycan and an engineered enzyme, enabling rapid and homogeneous antibody conjugates with therapeutic applications.

Mucosal and systemic neutralizing antibodies to norovirus and rotavirus by oral immunization with recombinant rotavirus in infant mice

This paper demonstrates that oral immunization with a recombinant rotavirus expressing norovirus VP1 induces systemic and mucosal neutralizing antibodies against both rotavirus and norovirus in infant mice.

Targeting Epsins by nanotherapy regulates lipid metabolism and promotes ABCG1-mediated cholesterol efflux to fortify atheroma regression

This study shows that targeting Epsins in macrophages with nanotherapy reduces lipid uptake and increases cholesterol efflux, promoting atheroma regression.

Mechano-epigenetic regulation of extracellular matrix homeostasis via Yap and Taz

The paper shows that mechanical tension regulates tendon cell function through Yap/Taz by modulating chromatin accessibility and catabolic gene expression.

Ticagrelor combined with aspirin displays the signature of regulating the gut microbiome in consistence with improving the immuno-inflammatory response in atherosclerosis

The paper was withdrawn due to insufficient cell culture data to clarify the mechanism of ticagrelor and aspirin's effect on the gut microbiome and immuno-inflammatory response in atherosclerosis.

Rotations improve the diversity of rhizosphere soil bacterial communities, enzyme activities and tomato yield

This study shows that rotating tomato with eggplant or arrowhead improves rhizosphere bacterial diversity, enzyme activity, and tomato yield and quality while reducing nitrate content.

Developmental Morphogens Direct Human Induced Pluripotent Stem Cells Towards an Annulus Fibrosus-like Cell Phenotype

This study identifies signaling factors that direct human iPSCs to an annulus fibrosus-like phenotype by comparing transcriptomic signatures with mature AF cells.

The structure of insulin granule core determines secretory capacity being reduced in type-2 diabetes

The paper investigates the structure of insulin granule cores and shows that their size reduction in type-2 diabetes correlates with impaired insulin secretion.

Azotobacter vinelandii scaffold protein NifU transfers iron to NifQ as part of the iron-molybdenum cofactor biosynthesis pathway for nitrogenase

The paper demonstrates that NifU transfers an [Fe-S] cluster to NifQ, enabling molybdenum incorporation into the nitrogenase cofactor in Azotobacter vinelandii.

Interaction network of SARS-CoV-2 with host receptome through spike protein

This study identifies multiple SARS-CoV-2 receptors, including ASGR1 and KREMEN1, which enable virus entry and correlate with multi-organ tropism and clinical symptoms.

Computational Compensatory Mutation Discovery Approach: Predicting a PARP1 Variant Rescue Mutation

This paper predicts a compensatory mutation for a PARP1 variant associated with cancer using coevolutionary analysis and molecular dynamics simulations.

Imaging the Extent and Location of Spatiotemporally Distributed Epileptiform Sources from MEG Measurements

This study applies the FAST-IRES algorithm to MEG data to image the location and extent of epileptiform sources in drug-resistant epilepsy patients.

Transcriptome analysis of SARS-CoV-2 naive and recovered individuals vaccinated with inactivated vaccine

The paper analyzes the transcriptome of SARS-CoV-2 naive and recovered individuals vaccinated with inactivated vaccine to understand immune response mechanisms and vaccine effectiveness.

Dalpiciclib and Pyrotinib Exert Synergistic Antitumor Effects in Triple Positive Breast Cancer

This study shows that combining dalpiciclib with pyrotinib is more effective than pyrotinib with tamoxifen in treating triple-positive breast cancer, with CALML5 as a potential biomarker.

Nanocrown electrodes for reliable and robust intracellular recording of cardiomyocytes and cardiotoxicity screening

This paper develops nanocrown electrodes for reliable intracellular recording of cardiomyocytes and demonstrates their use in cardiotoxicity screening.

A high throughput bispecific antibody discovery pipeline

This paper introduces a high throughput single-cell pipeline for bispecific antibody discovery, demonstrating its efficiency in identifying rare functional clones and uncovering design principles for improved immunotherapeutics.

Predicting hosts based on early SARS-CoV-2 samples and analyzing later world-wide pandemic in 2020

The paper introduces DeepHoF, a deep learning method to predict viral hosts, and applies it to SARS-CoV-2 to identify potential hosts and analyze host range uniformity during the pandemic.

miR-206 inhibits estrogen-induced proliferation and invasion of ER-α36 positive gastric cancer cells

This study shows miR-206 reduces estrogen-induced proliferation and invasion of ER-α36 positive gastric cancer cells by targeting CDK14.

Novel low-avidity glypican-3 specific CARTs resist exhaustion and mediate durable antitumor effects against hepatocellular carcinoma

Reflective mirror-based line-scan adaptive optics OCT

This paper introduces a reflective mirror-based line-scan adaptive optics OCT system for high-resolution retinal imaging, demonstrating cellular-scale structural and functional visualization in humans.

Antibody Cocktail Exhibits Broad Neutralization against SARS-CoV-2 and SARS-CoV-2 variants

This study identifies two antibodies, F61 and H121, that neutralize SARS-CoV-2 and its variants, including B.1.1.7 and B.1.351, by targeting distinct epitopes on the RBD.

CmP signaling network unveils novel biomarkers for triple negative breast cancer in African American women

The paper identifies 21 novel biomarkers for triple-negative breast cancer in African American women through analysis of the CmP signaling network.

Comprehensive Analysis of Spatial Architecture in Primary Liver Cancer

This study constructs high-resolution spatial transcriptomes of primary liver cancers to analyze spatial architecture and identify tumor microenvironment features.