Schizophrenia research and treatment

Genetic Epidemiological Pipeline Identifies Candidate Markers of Clozapine-Induced Metabolic Dysfunction Revealing Potential Avenues for Precision Clozapine Prescription

The paper identifies genetic markers linked to clozapine-induced metabolic dysfunction using Mendelian randomization and colocalization analyses, suggesting potential biomarkers for precision medicine.

In vivo mapping of protein-protein interactions of schizophrenia risk factors generates an interconnected disease network.

The paper maps protein-protein interactions of schizophrenia risk factors in rodent brains, revealing an interconnected disease network and showing how PCP perturbations alter these interactions.

Distributed neurophysiological dynamics link perception, action, and language in schizophrenia

This study identifies reduced beta-band neural modulation as a shared mechanism linking perceptual, motor, and language impairments in schizophrenia.

Zebrafish screen of schizophrenia risk genes reveals convergent dysregulation of cholesterol metabolism

The paper identifies dysregulation of cholesterol metabolism as a shared molecular consequence of schizophrenia risk mutations in zebrafish models.

Individual Brain Structure Deviations and its Gene Expression Signatures in Early-Onset Schizophrenia

This study identifies individual-level brain structure deviations and their gene expression signatures in early-onset schizophrenia, revealing two distinct transcriptomic subtypes associated with different neurodevelopmental processes.

Microstructural Disruption of the Forceps Minor in Schizophrenia: A Potential Clinical Imaging Biomarker Using Translational DTI

This study identifies microstructural abnormalities in the forceps minor white matter tract in schizophrenia using DTI, suggesting it as a potential biomarker and linking it to social behavior dysfunction.

A Dual-Pathway Prediction Error Model of Schizophrenia Spectrum Disorders:Bridging NMDA Hypofunction and Dopaminergic Hyperfunction

This paper proposes a neural model linking NMDA hypofunction and dopaminergic hyperfunction to schizophrenia spectrum disorders through prediction error pathways, explaining clinical diversity as a bias-volatility spectrum.

Higher-Order Thalamus is Pivotal in Schizophrenia-Associated Pathophysiology

The paper identifies higher-order thalamus as a critical node in schizophrenia pathophysiology, showing that restoring its activity can normalize connected brain regions.

Passage of time at the level of milliseconds: a new approach and a selective difficulty in individuals with schizophrenia

This study investigates time perception in schizophrenia by examining how individuals with schizophrenia and controls perform in detecting millisecond-level stimulus asynchronies, finding a specific difficulty in schizophrenia patients.

Sulcal Widening in Schizophrenia Maps onto Sulcal Hubs and Energy-Synaptic Genes

This study links sulcal widening in schizophrenia to network hubs and genes involved in synaptic signaling and energy metabolism.

Dissociable Anterior and Posterior Beta-Burst Dynamics Track Thought Disorder in Schizophrenia

This study examines beta-burst dynamics in schizophrenia patients and controls, finding dissociable anterior and posterior abnormalities linked to speech markers of thought disorder.

Unraveling Genetic Variants underlying Schizophrenia Phenotypes: An Original GWAS in Hong Kong Chinese with Cross-Ethnic Meta-Analysis and Predictive Modeling

This study conducts a GWAS and cross-ethnic meta-analysis of schizophrenia phenotypes in Hong Kong Chinese and European populations, identifying genetic variants and building predictive models for clinical outcomes.

Spatially resolved translational dysregulation in Grin2a+/- mouse model of schizophrenia

The paper uses spatial omics to analyze translational dysregulation in Grin2a+/- mice, finding gene-specific translation reductions in neurons and non-neuronal cells linked to schizophrenia pathophysiology.

Integration of gene expression with computational modeling reveals region-specific brain energy metabolism dysregulation in schizophrenia

The paper integrates gene expression analysis with computational modeling to show region-specific energy metabolism dysregulation in schizophrenia, identifying key genes and metabolite changes in ACC and DLPFC.

Cellular mechanisms underlying the pro-cognitive effects of serotonin 5-HT7 receptors in a mouse model of schizophrenia

This study investigates how 5-HT7 receptors modulate hippocampal-prefrontal circuits in schizophrenia models, finding that their blockade improves cognitive and emotional symptoms.

Convergent pathways with impaired inhibition at the frontal cortex are the outcome of differential alterations in the male and female schizophrenia model

This study identifies sex-specific molecular and functional changes in a schizophrenia model, revealing convergent inhibitory deficits through divergent pathways.

Higher inter-trial latency variability contributes to reduced visual EEG responses in schizophrenia

This study shows that increased inter-trial latency variability and reduced neural responses both contribute to diminished visual EEG N1 amplitudes in schizophrenia.

Elevated synaptic PKA activity and abnormal striatal dopamine signaling in Akap11 mutant mice, a genetic model of schizophrenia and bipolar disorder

This study investigates Akap11 mutant mice to explore the neurobiological effects of AKAP11 loss, finding increased PKA activity and transcriptomic changes linked to schizophrenia and bipolar disorder.

Cortical excitatory and inhibitory neuron deficits may underlie the cognitive and social impairments in a mouse model of schizophrenia with exonic Reln deletion

This paper investigates the role of Reelin in schizophrenia by analyzing a mouse model with exonic Reln deletion, finding deficits in excitatory and inhibitory neurons and suggesting therapeutic potential for Reelin replacement.

Altered striatal dopamine dynamics and behavior in Grin2a mutant mice, a genetic mouse model of schizophrenia

This study examines the effects of Grin2a and Akap11 mutations on striatal dopamine dynamics and behavior in mice, revealing distinct impacts on locomotion and neural activity.

The Dynamic Nature of Genetic Risk for Schizophrenia Within Genes Regulated by FOXP1 During Neurodevelopment

This study identifies FOXP1-regulated genes across developmental stages and shows their enrichment for schizophrenia heritability, particularly in early childhood and adolescence.

Transcriptomic analysis of the human habenula in schizophrenia

The paper performs transcriptomic analysis of the human habenula and identifies molecular changes associated with schizophrenia risk and illness state.

Linking Brain Entropy to Molecular and Cellular Architecture in Psychosis

The paper links brain entropy to molecular and cellular architecture in psychosis by analyzing differences in neurotransmitter systems and mitochondrial markers between healthy controls and individuals with schizophrenia or bipolar disorder.

A schizophrenia-associated radial glia cell state perturbs early human brain development

This study identifies a schizophrenia-associated radial glia cell state that disrupts early human brain development through single-cell transcriptomic and epigenomic analyses of organoids.

Neuroimaging Correlates of Altered Sense of Agency in First-Episode Schizophrenia-Spectrum Patients: A Comparative Study Across Two Sites

This study investigates altered sense of agency in first-episode schizophrenia patients using neuroimaging, finding consistent DMN hypo-activation across two independent cohorts.

Meta-analysis of the brain transcriptomes of multiple genetic mouse models of schizophrenia highlights dysregulation in striatum and thalamus

This study performs a meta-analysis of brain transcriptomes from genetic mouse models of schizophrenia, identifying dysregulation in striatum and thalamus with distinct patterns in different models.

Sex differences in latent inhibition and their implications for psychotic disorders

This paper reviews sex differences in latent inhibition, finding inconclusive evidence but suggesting sex differences in hippocampal processing and vulnerability to perturbations.

Targeting Amygdala-Brainstem Synapses to Reverse Prepulse Inhibition Deficits

The paper identifies CeA-PnC glutamatergic synapses as a therapeutic target for reversing PPI deficits in schizophrenia models using photo-tagging and PRODH-deficient mice.

Neuroanatomical Correlates of Negative Symptoms in Schizophrenia

This study identifies small but consistent anatomical correlates of negative symptom dimensions in schizophrenia, linking them to prefrontal cortical thickness and limbic subcortical volumes.

Theory of Mind and Discourse Production in Schizotypy: An fMRI Study

This study uses fMRI to examine neural correlates of schizotypal traits during discourse planning and production, finding trait-specific activation patterns in brain regions associated with theory of mind and social cognition.