Schizophrenia research and treatment

State-Dependent Transcriptomic Collapse of the Brain's Lactate and Ketone Thermodynamic Sensors in Schizophrenia

The paper identifies structural genomic variances in the HCAR2/HCAR1 locus that disrupt thermodynamic sensing in schizophrenia, linking metabolic dysfunction to clinical symptoms.

Non-uniform structural development across human thalamus aligns with risk zones for schizophrenia in adulthood

The paper examines thalamic structural development in humans, finding that nuclei with delayed maturation are at higher risk for schizophrenia and show distinct neuroreceptor patterns linked to symptom severity.

A Meta-Analysis of the Converging Effects of Different Classes of Antipsychotics on the Frontal Cortex Transcriptome in Laboratory Rodents and Non-Human Primates

This paper performs a meta-analysis of antipsychotic effects on frontal cortex transcriptomes in rodents and non-human primates, identifying 63 differentially expressed genes.

Disorganization impairs cognitive maps built from visual inputs

The paper shows that cognitive disorganization impairs the ability to form cognitive maps from visual input but not from linguistic structure.

D3 nutraceutical pre-supplementation ameliorates behavioral, ionotropic receptors, and synaptic proteins alterations in a MK-801 induced mouse model of schizophrenia

This study shows that vitamin D3 supplementation before MK-801-induced schizophrenia-like symptoms in mice improves behavioral deficits and restores gene expression of NMDA receptor subunits and nicotinic acetylcholine receptors.

Reduced synaptic plasticity and E/I imbalance drive Peripersonal Space boundaries expansion in Schizophrenia

The paper develops a computational model of peripersonal space (PPS) plasticity in schizophrenia, finding that reduced synaptic plasticity mechanisms can explain PPS expansion despite E/I imbalance.

Reactivating a schizophrenia risk gene-enriched prefrontal ensemble suppresses decision noise

The paper identifies a schizophrenia risk gene-enriched prefrontal ensemble that stabilizes decision-making and shows that reactivating it with a multi-receptor antagonist cocktail suppresses decision noise without sedation.

Multiplex Portuguese Families as a Lens into rare mutations and the Shared Genetic Architecture of Schizophrenia, Mood Disorders, and Autism Spectrum Disorders

This study analyzes 173 multiplex Portuguese families to identify rare genetic variants associated with schizophrenia, mood disorders, and autism, finding a CHD2 mutation linked to diverse mental illness phenotypes.

Liquidity of gene co-expression trajectories across the lifespan highlights delayed maturation and the perinatal GABA switch in schizophrenia risk

The paper uses a novel 'liquidity' metric to analyze gene expression trajectories across lifespan, revealing delayed maturation and perinatal GABA switch in schizophrenia risk without detectable neuropathology.

Perturbation of genes linked to common schizophrenia risk variants identifies cilia programs

The paper perturbs schizophrenia risk genes in mice to identify ciliary transcriptional programs as a potential downstream mechanism of disease.

Protein-state dysregulation and sex-specific neurodevelopmental signatures in schizophrenia forebrain organoids

This study uses forebrain organoids to show that schizophrenia involves sex-specific protein-state dysregulation, with changes in post-translational modifications and proteomic pathways rather than transcript levels.

Symptom Dimension-Specific Neurotransmitter Correlates of Psychopathology and Cognition in Early Psychosis

The paper identifies neurotransmitter systems linked to specific symptom dimensions in early psychosis using neuroimaging and PET data.

Linking reduced prefrontal microcircuit inhibition in schizophrenia to EEG biomarkers in silico

This study links reduced PV and SST interneuron inhibition in schizophrenia to distinct EEG biomarkers using in silico simulations of prefrontal microcircuits.

Gene-Set Based Rare Variant Association Analysis of Whole Genome Sequencing Data in the Portuguese Island Collection for Schizophrenia and Bipolar Disorder

The paper performs rare variant association analysis using whole-genome sequencing data from the Portuguese Island Collection to identify shared genetic pathways in schizophrenia and bipolar disorder.

Dysregulation of miRNAs Drives Premature GABAergic Maturation and Early Neurodevelopmental Defects in Schizophrenia

This study uses brain organoids to show that miRNA dysregulation in schizophrenia leads to premature GABAergic maturation and neurodevelopmental defects.

Cariprazine modulates intrinsic excitability and network dynamics of hippocampal neurons in a cell-type dependent manner

This study investigates cariprazine's effects on hippocampal neurons, showing cell-type-dependent changes in excitability and network dynamics through electrophysiology and modeling.

Mapping spatially organized molecular and genetic signatures of schizophrenia across multiple scales in human prefrontal cortex

This study maps molecular and genetic signatures of schizophrenia in human prefrontal cortex across spatial scales, revealing altered BDNF-TrkB signaling and inhibitory circuit dysfunction.

Schizophrenia, variability, and the Anna Karenina principle

The paper shows that higher variance in schizophrenia patients arises from greater perturbation counts, not disease-specific factors, highlighting the need to address broad damaging factors rather than specific pathologies.

A Small-Molecule Mitochondrial Complex I Modulator Improves Behavioral and Mitochondrial Dysfunction in Schizophrenia

The paper tests a small-molecule inhibitor of mitochondrial complex I in a schizophrenia mouse model, finding it improves mitochondrial function and behavioral deficits.

Schizophrenia risk gene ZNF804A controls ribosome localization and synaptogenesis in developing human neurons

This study investigates the role of ZNF804A in human neurodevelopment, finding it regulates excitatory synapse formation through increased local protein translation in developing cortical glutamatergic neurons.

Genetic Risk and Resilience for Schizophrenia Stratified by Perinatal Gene Expression Predict Adult Cognitive Performance

The paper examines how schizophrenia genetic risk and resilience variants, co-expressed in the human brain, are associated with cognitive performance across development in 16,520 individuals.

Effects of NMDA antagonists on social behaviour: a systematic review and meta-analysis of preclinical studies

This study reviews and analyzes preclinical data on NMDA antagonists' effects on social behavior, finding reduced social interaction and preference, with mixed effects of antipsychotics.

Developmental Bioenergetic Reprogramming and Glycolytic Shift in Schizophrenia Vulnerability

This study investigates how early developmental metabolic changes in mouse models relate to schizophrenia vulnerability, finding increased glycolytic activity as a potential convergent mechanism.

High prevalence of CNS-directed autoantibodies in patients with schizophrenia

This study identifies a high prevalence of CNS-directed autoantibodies in schizophrenia patients, linking them to disease severity, treatment resistance, and potential therapeutic targets.

Distinct effects of sensory and genetic risk factors for psychosis on auditory cortical temporal acuity in a mouse model of 22q11.2 Deletion Syndrome

The paper investigates how sensory and genetic risk factors for psychosis affect auditory cortical temporal acuity in a mouse model of 22q11.2 deletion syndrome, finding distinct mechanisms for each factor.

Fronto-Temporal Dysconnectivity and Cortical Excitability in High Schizotypy: Associations with Symptom Dimensions

This study investigates whether biological mechanisms of schizophrenia, such as dysconnectivity and E/I imbalance, are present in individuals with high schizotypy, supporting a psychosis-continuum hypothesis.

Rare coding variants in schizophrenia-associated genes affect generalised cognition in the UK Biobank

The paper investigates the effect of rare coding variants in schizophrenia-associated genes on generalised cognition in the UK Biobank using exome-sequencing data.

Antipsychotic-like effects of the selective Rho-kinase 2 inhibitor KD025 in genetic and pharmacological mouse models of schizophrenia

This study shows that the selective ROCK2 inhibitor KD025 has antipsychotic-like effects and fewer side effects in schizophrenia models.

A single dose of the antipsychotic drug clozapine has long-term behavioral and functional effects in mice

A single dose of clozapine in mice causes long-term behavioral and functional changes in the cortex, lasting up to 9 days, affecting specific neuron subsets and inhibitory circuits.

Dissociation Between Genetic Risk and Transcriptional Output in Schizophrenia: A Cross-Tissue Meta-Analysis of CSMD1 and CSMD2 Expression

The paper finds that CSMD2 is overexpressed in brain tissues of schizophrenia patients, while CSMD1 shows no difference, suggesting a dissociation between genetic risk and transcriptional output.