Bone health and osteoporosis research

Bone response to intermittent parathyroid hormone (PTH) is both genetic and sex specific

This study investigates genetic and sex-specific factors influencing bone response to PTH in mice, finding strong heritability and sex-dependent mechanisms.

Short- and Long-Term Effects of Social Isolation on Adult Murine Bone are Sex-Dependent

This study shows that social isolation reduces bone parameters in male mice but not females, with effects appearing rapidly in males and some changes in females after short-term isolation.

Osteoporosis Genetic Risk Prediction Using Bone Mineral Density Polygenic Scores in Japanese: TMM CommCohort Study

The paper develops and validates a polygenic score for osteoporosis in Japanese individuals using heel quantitative ultrasound data, showing genetic risk stratification.

Strontium treatment potentiates bone anabolic action of intermittent PTH in ovariectomized rats

This study shows that combining strontium with PTH1-34 enhances bone formation and strength in ovariectomized rats.

Combination of 3D and 2D small and wide angle X-ray scattering imaging reveals diminished bone quality in the superior human femoral neck cortex

This study uses 2D and 3D X-ray scattering imaging to analyze bone nanostructure in the femoral neck, finding material property differences that may increase fracture risk in the superior region.

Quantifying Brittle Crack Opening in Human Trabecular Bone Using Synchrotron XCT-DVC

This paper uses synchrotron XCT-DVC to quantify crack opening in human trabecular bone, finding lower critical crack-opening ratios in hip-fracture donors compared to controls.

Early intermittent low-dose sclerostin antibody treatment promotes surface bone formation and reduces bone loss, but also decreases osteocyte apoptosis and mechanotransduction in ovariectomized rats: a pilot study

Cell type-specific network analysis in Diversity Outbred mice identifies genes potentially responsible for human bone mineral density GWAS associations

The paper uses single-cell transcriptomics in mice to identify cell type-specific networks and prioritize genes associated with human bone mineral density GWAS findings.

Combined physical and pharmacological anabolic osteoporosis therapies increase bone response and mechanoregulation in female mice

This study shows that combining physical and pharmacological anabolic therapies improves bone strength and mechanoregulation in female mice with osteoporosis.

Mathematical Modeling of Bone Remodeling after Surgical Menopause

The paper develops a mathematical model to simulate bone remodeling after surgical menopause, showing increased bone loss initially and a long-term rebound in bone density.

In C57Bl6 Mice, Obesity and Subsequent Weight Loss Negatively Affected the Skeleton and Shifted the Cortical Bone Metabolome

This study shows that obesity and calorie restriction both harm bone health in mice, with calorie restriction causing more severe bone loss and metabolic changes in a sex-dependent manner.

GWAS-informed data integration and non-coding CRISPRi screen illuminate genetic etiology of bone mineral density

The paper integrates GWAS data with a CRISPRi screen in osteoblasts to identify genes affecting bone mineral density and reveals pleiotropy across non-bone tissues.

Aromatase in adipose tissue exerts an osteoprotective function in male mice via phosphate regulation

This study shows that aromatase in adipose tissue protects bone in male mice by regulating phosphate reabsorption via NaPi2 proteins.

The GLP-1 analogue, exendin-4, improves bone material properties and strength through a central relay in ovariectomized mice

This study shows that exendin-4 improves bone strength in ovariectomized mice through a central mechanism, not directly on bone cells.

Runaway resorption of microcracks contributes to age-related hip-fracture patients

The paper investigates microdefects in hip-fracture patients and finds they are more prevalent and negatively correlate with bone strength.

The mineralization of osteonal cement line depends on where the osteon is formed

This study investigates CL mineralization in human femoral samples, finding that CL mineral content correlates with surrounding bone mineral content and increases over time but at a slower rate than the osteon.

High-fat diet exacerbates the loss of bone fracture toughness in aging for C57BL/6JN mice

This study shows that high-fat diet worsens age-related loss of bone fracture toughness in C57BL/6JN mice.

Combined effects of mechanical loading and Piezo1 chemical activation on 22-months-old female mouse bone adaptation

This study examines how mechanical loading and Piezo1 activation affect bone adaptation in aged mice, finding an additive effect on cortical bone parameters.

Thermoneutral Housing has Limited Effects on Social Isolation-Induced Bone Loss in Male C57BL/6J Mice

This study tests if thermoneutral housing prevents social isolation-induced bone loss in male mice but finds no such effect, suggesting cold stress is not the primary mechanism.

Dimeric R25CPTH(1-34) Activates the Parathyroid Hormone-1 Receptor in vitro and Stimulates Bone Formation in Osteoporotic Female Mice

This study shows that the dimeric PTH variant R25CPTH(1-34) activates the PTH1R and improves bone formation in osteoporotic mice.

Osteoporosis with different causation exhibits different changes in bone tissue mineral and organic matrix

This study compares bone quality changes in osteoporosis caused by aging, ovariectomy, and diabetes using SD rats, revealing distinct molecular and structural alterations.

3D spatial distribution of Sost mRNA and Sclerostin expression in response to in vivo mechanical loading

This study uses WISH-BONE to analyze 3D Sost mRNA and sclerostin distribution in mouse tibia midshafts after mechanical loading, showing region-specific changes and highlighting the method's importance for mechanoadaptation research.

Spatial histomorphometry reveals that local peripheral nerves modulate but are not required for skeletal adaptation to applied load in mice

Effects of vertical sleeve gastrectomy prior to pregnancy on bone mass, microarchitecture and material properties in the female rat

This study examines how vertical sleeve gastrectomy before pregnancy affects bone mass, microarchitecture, and material properties in female rats fed a high-fat high-sugar diet.

Loss of cped1 does not affect bone and lean mass in zebrafish

This study investigates the role of cped1 in zebrafish bone and lean mass, finding no significant effects on these traits despite loss of function.

Consolidated Calcium kinetic rates in a Caucasian population as a function of age and sex

The paper consolidates age- and sex-dependent calcium kinetic rates in a Caucasian population for use in toxicokinetic modeling.

Impact of high fat diet and exercise on bone and bile acid metabolism in rats

This study examines how high fat diet and exercise affect bone and bile acid metabolism in rats, finding that HFD reduces bone mass and alters bile acid levels, while exercise improves bone quality in lean rats but not in HFD-fed rats.

Multi-Scale Cortical Bone Traits Vary in Two Mouse Models of Genetic Diversity

This study examines how genetic diversity affects multi-scale cortical bone traits in two mouse populations, finding significant heritability and hybrid phenotypes in outbred mice.

Lowering of circulating sclerostin may increase risk of atherosclerosis and its risk factors: evidence from a genome-wide association meta-analysis followed by Mendelian randomization

This study uses GWAS and Mendelian randomization to show that lower sclerostin levels increase risk of hypertension, type 2 diabetes, myocardial infarction, and atherogenic lipid profiles.

Impaired bone strength and bone microstructure in a novel early-onset osteoporotic rat model with a clinically relevant PLS3 mutation

This study creates a novel rat model with a PLS3 mutation to study early-onset osteoporosis and finds that alendronate and teriparatide improve bone strength and microstructure.