Epilepsy research and treatment

Respiratory dysfunctions in two rodent models of chronic epilepsy and acute seizures and their link with brainstem serotonin system

This study examines respiratory dysfunctions in rodent epilepsy models and links them to changes in the brainstem serotonin system.

Reactive astrocyte-driven epileptogenesis is induced by microglia initially activated following status epilepticus

This study shows that sequential activation of microglia and astrocytes contributes to epileptogenesis after status epilepticus, with reactive astrocytes playing a key role in seizure susceptibility.

Visualization of Phase-Amplitude Coupling Using Rhythmic High-Frequency Activity

The paper visualizes phase-amplitude coupling during seizures by creating a video that shows how ripple activity is modulated by low-frequency rhythms.

Low grade inflammation in the epileptic hippocampus contrasts with explosive inflammation occurring in the acute phase following status epilepticus in rats: translation to patients with epilepsy

The paper compares inflammation levels in the hippocampus of mTLE patients and rat models of epilepsy, finding lower chronic inflammation in patients compared to acute post-SE inflammation in rats.

Maternal behavior and the neonatal HPA axis in the Wistar Audiogenic Rat (WAR) strain: early life implications for a genetic animal model in epilepsy

The paper evaluates the neonatal HPA axis function and maternal behavior in the WAR strain under stress conditions, finding higher corticosterone levels and altered maternal behavior in WAR pups.

Mecamylamine inhibits seizure-like activity in CA1-CA3 hippocampus through antagonism to nicotinic receptors

This study shows mecamylamine reduces seizure-like activity in hippocampal slices by blocking nicotinic receptors, independent of glutamate and GABA transmission.

Quantifying a Frequency Modulation Response Biomarker in Responsive Neurostimulation

The paper quantifies a frequency modulation response biomarker in responsive neurostimulation to improve seizure control in epilepsy patients.

Spatio-temporal heterogeneity in hippocampal metabolism in control and epilepsy conditions.

The paper shows that hippocampal metabolism varies along the dorsoventral axis and over time in control mice, with changes in epilepsy affecting this spatio-temporal pattern.

Suppression of PIK3CA-driven epileptiform activity by acute pathway control

The paper identifies PI3K and AKT inhibition as effective in suppressing PIK3CA-driven epileptiform activity in a mouse model, offering a potential therapeutic strategy for drug-resistant epilepsy.

Proteomic Differences in the Hippocampus and Cortex of Epilepsy Brain Tissue

The paper identifies proteomic differences in epilepsy brain tissue, highlighting altered protein networks in hippocampus, cortex, and dentate gyrus, with GNB1 as a key decreased protein.

Synergistic positive feedback underlying seizure initiation

The paper identifies synergistic positive feedback mechanisms that drive seizure initiation and shows that an optogenetic stimulation paradigm can delay epileptic activity.

Evidence for spreading seizure as a cause of theta-alpha activity electrographic pattern in stereo-EEG seizure recordings

This study investigates whether theta-alpha activity patterns in seizure recordings are caused by spreading seizures, finding support for this hypothesis through simulations and comparisons with real patient data.

Neuronal kinase SGK1.1 protects against brain damage after status epilepticus

This paper shows that SGK1.1 activation reduces neuronal death and gliosis after status epilepticus, acting through both M-current regulation and anti-apoptotic mechanisms.

Limb-clasping, cognitive deficit and increased vulnerability to kainic acid -induced seizures in neuronal GPI anchor deficiency mouse models

This study generates PIGA-deficient mouse models to investigate the role of GPI anchor deficiency in neurological phenotypes and seizure susceptibility.

Shared genetic underpinnings between genetic generalized epilepsy and background EEG oscillations

This study identifies strong genetic correlations between genetic generalized epilepsy and background EEG oscillations, particularly in the beta frequency band, suggesting shared biological mechanisms.

Phenotypic analysis of catastrophic childhood epilepsy genes: The Epilepsy Zebrafish Project

The paper generates zebrafish models for 8 catastrophic childhood epilepsy genes and develops a classification scheme and open-source database for these models.

Spatiotemporal dynamics between interictal epileptiform discharges and ripples during associative memory processing

This study examines how interictal epileptiform discharges (IEDs) affect memory during encoding and retrieval, finding they reduce memory success and disrupt hippocampal ripples.

Genetic and pharmacological manipulations of glyoxalase 1 mediate ethanol withdrawal seizure susceptibility in mice

This study shows that genetic and pharmacological manipulations of GLO1 affect ethanol withdrawal seizure severity in mice.

Sodium channel Nav1.2-L1342P variant displaying complex biophysical properties renders hyperexcitability of cortical neurons derived fromhuman iPSCs

This study investigates the effects of the SCN2A L1342P variant in human iPSC-derived neurons, showing increased excitability and resistance to phenytoin, but responsiveness to PTx3.

Aberrant regulation of a poison exon caused by a non-coding variant in Scn1a-associated epileptic encephalopathy

This study identifies a non-coding variant in SCN1A that causes aberrant inclusion of a poison exon, leading to reduced Nav1.1 expression and Dravet syndrome in a mouse model.

Utilizing Multimodal Imaging to Visualize Potential Mechanism for Sudden Death in Epilepsy

The paper uses multimodal imaging and electrophysiology to visualize acid reflux-induced laryngospasm and cardiorespiratory distress in seizing rats, linking it to sudden death.

The contribution of astrocyte and neuronal Panx1 to seizures is model and brain region dependent.

This study investigates the role of astrocyte and neuronal Panx1 in seizures across different models and brain regions, finding that their contribution varies depending on the model, cell type, and brain region.

Spatiotemporal patterns of high-frequency activity (80-170 Hz) in long-term intracranial EEG

This study analyzes long-term intracranial EEG recordings to examine variability and circadian patterns of high-frequency activity and epileptiform spikes in patients with drug-resistant epilepsy.

Fast oscillations >40Hz localize the epileptogenic zone: an electrical source imaging study using high-density electroencephalography

This study shows that fast oscillations >40Hz detected with high-density EEG can accurately localize the epileptogenic zone, outperforming conventional EEG methods.

In vitro characterisation and neurosteroid treatment of an N-Methyl-D-Aspartate receptor antibody-mediated seizure model

This study develops an NMDAR-Ab-mediated rat seizure model and shows that reducing excitatory neurotransmission, not inhibitory, causes seizures, which can be mitigated by a neurosteroid.

Closed-loop stimulation of the medial septum terminates epileptic seizures

This study shows that closed-loop electrical stimulation of the medial septum can terminate seizures and prevent their spread in a rat model.

Cell type-specific isolation and transcriptomic profiling informs glial pathology in human temporal lobe epilepsy

The paper isolates and profiles cell types in human TLE samples, revealing dysregulated pathways and an immature glial phenotype.

Removal of KCNQ2 from Parvalbumin-expressing Interneurons Improves Anti-Seizure Efficacy of Retigabine

This study shows that removing KCNQ2 from parvalbumin-expressing interneurons enhances the anti-seizure efficacy of retigabine.

Focal cortical surface cooling is a novel and safe method for intraoperative functional brain mapping

This paper evaluates the safety of focal cortical cooling as an alternative to electrical cortical stimulation for intraoperative functional brain mapping, finding no intraoperative seizures and comparable post-operative outcomes.

Optogenetic activation of the serotonergic neural circuit between dorsal raphe nucleus and the pre-Bötzinger complex contributes to inhibition of the seizure-induced respiratory arrest in the DBA/1 mouse SUDEP model