Developmental Biology and Gene Regulation

Temperature scaling of developmental tempo reveals reaction-dominated morphogen patterning

The paper investigates how morphogen gradients remain robust under temperature-induced changes in developmental tempo in medaka embryos, finding that reaction kinetics, not diffusion, drive this robustness.

3D MERFISH reveals cell-type diversity generated by mRNA partitioning in spiralian embryogenesis

The paper uses 3D MERFISH to show that mRNA partitioning during cell division generates transcriptomically distinct cell types in Crepidula atrasolea embryos.

Spatially restricted bmp16 in an extra-embryonic syncytium promotes dorsoventral patterning

The paper identifies bmp16 expression in the zebrafish yolk syncytial layer and shows its role in dorsoventral patterning through functional perturbations.

The Par complex regulates apical-basal cell polarity through modulation of FAK signaling homeostasis

This study shows that the Par complex regulates cell polarity and differentiation by modulating FAK signaling through the AKT-FURIN-LEFTY pathway in mouse embryonic stem cells.

Optogenetic BMP4 models symmetry breaking and primitive streak formation in hPSCs

This paper introduces LightBMP, an optogenetic tool to control BMP4 in hPSCs, showing spatial BMP4 patterns can drive symmetry breaking and primitive streak formation without mechanical cues.

Cldn18 evolution reveals pleiotropic constraints in vertebrate stomach loss

The paper analyzes the evolution of CLDN18 across vertebrates, showing gene loss, alternative splicing, and regulatory changes linked to stomach loss and pleiotropy.

Comprehensive Lineage Tracing Maps the Landscape of Cell Fate Decisions in Mouse Embryogenesis

Prime-editing lineage trees for 16 mouse embryos (E7.5 to E10.0, >1.4 million cells) quantify fate restriction timing, progenitor numbers and lineage relationships, and are reproducible across replicate embryos.

Possible function of Hox2 in atrial siphon fusion of the ascidian Ciona

This study shows Hox2 is required for atrial siphon fusion in Ciona, with Hox2-knockout animals retaining two siphons and lacking cupular organs.

Reconstruction of the Prox gene family evolution in vertebrates reveals multiple lineage-specific gene losses

This study reconstructs the evolutionary history of the Prox gene family in vertebrates, revealing lineage-specific gene losses and identifying a fourth ancestral Prox gene.

Cell Position-Associated Division Orders and Cell Cycle Durations Shape Asymmetric Trajectories of Cell Fates and Morphological Events in Pre- and Peri-implantation Mouse Embryos

This study shows that cell position, division order, and cell cycle dynamics shape asymmetric cell lineage and morphological events in pre- and peri-implantation mouse embryos.

Network topology reveals distinct forms of developmental leverage in the Drosophila wing

The paper analyzes the Drosophila wing developmental network to show how network topology reflects developmental leverage through distinct hierarchical layers and roles.

Stochastic Modeling of BMP Heterodimer-Receptor Interactions Shows Emergence of Low-Pass Filtering Behavior

The paper develops a stochastic model of BMP receptor interactions to show the heterodimer-heterotetramer complex functions as a low-pass filter in zebrafish dorsoventral axis formation.

Engineered dual-gastruloid model for foregut-pharyngeal mesoderm co-development

This paper introduces a dual-gastruloid model to study the co-development of foregut-pharyngeal mesoderm in mice, showing the role of Foxa2 in Tbx1 expression.

Fine-tuning neuron number: Lzts as a key regulator of neurogenesis and cell proliferation in Ciona

This study identifies Lzts as a regulator of neuron number in Ciona by controlling cell-cycle timing through a conserved Lzts-Cdc25-Cdk1 circuit.

NANOG is dispensable for hypoblast but essential for embryonic disc development during conceptus elongation in sheep

This study shows NANOG is not needed for hypoblast development but is essential for epiblast maintenance and embryonic disc formation in sheep during conceptus elongation.

The SynMuvA lin-15A licenses natural transdifferentiation by antagonizing identity safeguarding mechanisms

The paper identifies lin-15A as a Licenser that facilitates transdifferentiation by antagonizing identity safeguarding mechanisms in C. elegans.

Transcriptional coupling of metabolism and cell mechanics controls humanneuroepithelium morphogenesis

The paper identifies PAX3's role in coupling metabolism and cell mechanics during neuroepithelial morphogenesis, showing mannose metabolism is critical for adherens junction function.

A germline-specific reporter reveals conserved primordial germ cell developmental dynamics between jawless and jawed fish species

This study develops a germline-specific reporter in a jawless vertebrate, revealing conserved germline regulatory mechanisms and PGC dynamics across jawless and jawed species.

FoxP transcription factors are required for peripheral nervous system development

This study shows FoxP transcription factors are essential for peripheral nervous system development in chicken embryos, affecting axon guidance and neural crest cell migration.

In utero barcoding of mouse mesoderm reveals the clonal architecture of organ mesenchyme

The paper uses in utero barcoding and single-cell transcriptomics to map clonal relationships in mouse mesoderm-derived tissues, revealing lineage relationships in liver and heart mesenchyme.

A Cre-responsive reporter quail for flexible genetic lineage tracing

This paper develops a Cre-responsive transgenic quail line for flexible genetic lineage tracing, enabling permanent labelling of embryonic cell populations through Cre-mediated recombination.

Ancient Somatosensory Circuit Architectures Employ Flexible Molecular Strategies

This study shows that while spinal somatosensory circuit organization is conserved in skates, molecular programs specifying sensory neuron subtypes are distinct from mammals.

The transcription factor THAP11 is a general regulator of early embryonic polarization

This study identifies THAP11 as a general regulator of early embryonic polarization across three developmental stages in mice, showing its role in cell fate and morphogenesis.

twist1a and twist1b play overlapping roles during zebrafish pectoral fin development

This study shows that twist1a and twist1b redundantly regulate zebrafish pectoral fin development by maintaining the apical ectodermal ridge and fin field formation.

Embryonic and larval development of the Pacific saury Cololabis saira: Distinctive characteristics of a rapidly growing beloniform fish

The paper documents the embryonic and larval development of Pacific saury, highlighting unique developmental patterns and rapid growth compared to related species.

Cross-species analysis links cell-cell communication rewiring to NOTCH2 during serous endometrial carcinogenesis

Regional Signaling Controls Stem Cell-Mediated Regeneration in an Invertebrate Chordate

The paper identifies region-specific signaling cues that control stem cell-mediated regeneration in the invertebrate chordate Ciona robusta.

Serine/Threonine phosphatase PP1 is a regulator of Notch signalling.

This study identifies PP1 and PNUTS as regulators of Notch signaling in Drosophila neurogenesis by dephosphorylating Su(H) to activate downstream targets.

Human foregut morphogenesis exhibits murine-like molecular patterning but avian-like epithelial architecture

The paper compares human, mouse, and chick foreguts to show human foregut combines mouse-like molecular patterning with chick-like epithelial architecture, suggesting chick embryos are useful for studying human foregut malformations.

Three-dimensional imaging reveals distinct muscle-vessel-nerve relationships during dorsal and ventral muscle splitting in the chicken forelimb

This study uses 3D imaging to show that vascular and nerve patterns differ between dorsal and ventral muscle splitting in chicken forelimbs, indicating distinct local tissue environments for splitting events.