Genetics, Aging, and Longevity in Model Organisms

A New Soaking Protocol to Live Stain C. elegans with Proteostat Dye Reveals Global Patterns of Stress-Induced Protein Aggregation

The paper introduces a new soaking protocol to label protein aggregates in live C. elegans using Proteostat dye, enabling visualization and quantification across tissues and genotypes.

Sex-stratified immune patterns across the canine lifespan and short-term responses to geroprotective interventions

This study examines age-related immune changes and short-term responses to geroprotective interventions in dogs, finding sex-stratified cytokine patterns and varied intervention effects.

An integrated resource for systems-level analysis of aging hallmarks and associated genes

This paper introduces AgingHallmarksDB, a resource for systems-level analysis of aging hallmarks and associated genes, demonstrating its utility through various analyses of disease and transcriptome data.

A mechanistic, mortality-referenced biological age from routine blood tests: construction and temporal validation of IQN-BIOAGE-01

The paper constructs and validates a mechanistic biological age model, IQN-BIOAGE-01, that decomposes mortality risk into organ-specific axes and compares it to existing statistical clocks.

Loss of the fatty acid β-oxidation gene acaa-2 impairs timely hatching under poor maternal diet in C. elegans

The paper identifies acaa-2 as a gene critical for developmental robustness in C. elegans under poor maternal diet, showing hatching delays in mutants when mothers are malnourished.

Stress-recovery dynamics reveal a separatrix in transcriptomic landscapes across organs and aging

The paper uses transient stress and recovery in mice to analyze transcriptomic stability across organs and aging, identifying a separatrix in testis that determines recovery capacity.

Apigenin Improves Healthspan and Protects Against Alzheimer's Disease-Associated Proteotoxicity in C. elegans

This study shows apigenin extends healthspan and protects against Alzheimer's proteotoxicity in C. elegans by reducing oxidative stress and improving physiological function.

Inferring organ aging, hallmark of aging and senescence scores from blood and facial photographs

The paper develops methods to infer organ aging, senescence, and hallmark scores from blood transcriptomes and facial photographs, showing associations with mortality.

Lifespan-extending downregulation of insulin signalling reduces germline mutation load

This study shows that reducing insulin signaling in adulthood extends lifespan and reduces germline mutations in C. elegans, but only when the HRDE-1 pathway is functional.

NLP-12/Cholecystokinin signaling stabilizes sensory dendritic structure and protects neuronal healthspan in Caenorhabditis elegans

This study identifies NLP-12 as a neuropeptide that preserves neuronal structure and function in C. elegans by preventing excessive dendritic branching and maintaining proprioceptive ability during aging.

Somatic mutations and single-nucleus transcriptomics reveal uniquely human properties of neuronal aging

The paper compares somatic mutation rates and transcriptomic changes in neurons across six mammalian species, finding higher mutation accumulation and distinct age-related dysregulation in human neurons.

Age-Related Remodeling of Cross-Tissue Transcriptional Coordination in the Human Motor System

The paper examines age-related transcriptional changes across multiple tissues in the human motor system and finds that cross-tissue coordination declines in later life.

Neuropeptides NLP-10 and FLP-18 stimulate lipid catabolism in chronically diet-restricted Caenorhabditis elegans

The paper identifies a neuropeptide signaling cascade in C. elegans that promotes lipid catabolism under dietary restriction and during starvation.

An AI-ready compositional framework for mechanistic aging research and in silico intervention testing

The paper introduces a compositional simulation framework for aging research that enables the integration and testing of mechanistic models using AI agents.

Caloric restriction drives age-dependent and integrated remodeling of RNA processing and lipid composition in mouse brain

This study shows that caloric restriction in mice alters RNA processing and lipid composition across adulthood, linking these changes to metabolic reprogramming and lifespan extension.

HLH-30/TFEB is necessary for chromatin reorganization and maintenance of cell quiescence during starvation in C. elegans

This study shows HLH-30/TFEB is essential for chromatin reorganization and cell quiescence during starvation in C. elegans, with loss of HLH-30 disrupting cell cycle arrest and causing premature developmental activation.

Genetic Variation in Organ System Decline Across the Drosophila Genetics Reference Panel

The paper measures age-related organ system decline in 19 Drosophila lines to show genetic variation in physiological decline patterns across genotypes.

Chronological lifespan correlates with virulence within Candida albicans but long lifespan is not restricted to pathogenic Candida species

The paper examines chronological lifespan (CLS) in Candida species, finding that longer CLS correlates with virulence in C. albicans but not across species.

A composite frailty index enables quantification of functional aging and identification of gerotherapeutic drugs in the house cricket.

The paper introduces a Composite Frailty Index (CFI) in house crickets to quantify functional aging and identify gerotherapeutic drugs.

Divergent Retrograde Signaling Pathways Coordinate Longevity and Metformin Responses in Complex I and Complex IV Deficient C. elegans

This study shows that Complex I and Complex IV deficiencies in C. elegans activate distinct retrograde signaling pathways for longevity and metformin response, challenging the uniformity of mitohormesis.

Metabolic outsourcing from ingested lactic acid bacteria extends Caenorhabditis elegans healthspan via bacterial amino acid and enzyme provision

This study shows that live lactic acid bacteria extend C. elegans healthspan by providing amino acids and enzymes that support collagen maintenance, bypassing host energy expenditure.

RICTOR regulates an interspecies crosstalk that influences longevity through a novel methionine cycle-mitophagy axis

This study identifies RICTOR as a regulator of dietary plasticity in C. elegans, showing it modulates longevity through a methionine cycle-mitophagy axis influenced by bacterial vitamin B12.

Developmental regulation of progenitor aging shapes long-term intestinal homeostasis in Drosophila

This study shows that manipulating cellular aging in larval Drosophila midgut progenitors affects long-term intestinal aging and homeostasis in adults.

Nutritional history affects stress-resistance architecture across ageing and sex

This study shows that nutritional history during development and adulthood affects stress resistance traits differently across age and sex in Drosophila, with distinct patterns in covariance and response to dietary changes.

Convergent Amino-Acid Substitutions Link Primate Longevity to Male-Fertility Genes

The paper identifies convergent amino-acid substitutions in primate species linked to male-fertility genes and longevity.

Cysteine reduction rather than methionine restriction promotes immunometabolic fitness to confer survival benefit in aging

This study shows that reducing cysteine, not methionine, improves immunometabolic fitness and extends healthy lifespan in aging organisms.

An atlas of the C. elegans starvation response reveals that transcription is necessary to initiate transcriptional silencing in quiescent primordial germ cells

The paper creates a cellular atlas of gene expression in fed and starved C. elegans L1 larvae, revealing transcription in starved primordial germ cells and the role of aak-1/AMPK in chromatin compaction.

Pre-symptomatic proteomic and metabolomic profiling identifies compensated ER-redox-metabolic adaptation and early nuclear vulnerability in neuronal ERO1L toxicity

The paper identifies pre-symptomatic proteomic and metabolomic changes in Drosophila due to neuronal ERO1L elevation, revealing adaptive responses and early nuclear vulnerability before functional decline.

Leucine Regulates Neuronal Health During Nutrient Deprivation in Caenorhabditis elegans

This study shows that leucine, a branched-chain amino acid, prevents neuronal damage and behavioral decline in C. elegans during prolonged nutrient deprivation.

Elevated mitochondrial superoxide promotes longevity through a mitochondria-to-nucleus kinase signaling pathway

This study identifies a mitochondria-to-nucleus kinase signaling pathway that promotes longevity in sod-2 mutants by upregulating innate immunity and cuticle formation genes.