Genetics, Aging, and Longevity in Model Organisms

This study identifies strain-specific longevity benefits of human gut Bifidobacteria in C. elegans, showing they rely on distinct cytoprotective pathways but share dependence on host lipid regulation.

The paper examines an energetic trade-off model linking inflammaging and immunosenescence using data from the US Health and Retirement Study and UK Biobank, finding evidence of TNFR1 and GDF15 mediating age-related immune declines and health risks.

This study identifies early brain-wide reductions in cell size and volume during adulthood in Drosophila melanogaster, linked to aging and modifiable by Myc overexpression.

The paper uses iPSC-derived neurons from centenarians to identify resilience signatures associated with longevity, showing enhanced stress response and specific transcriptional programs.

This study identifies bacterial exposure as a key driver of immune ageing and shows residual bacterial DNA in immune cells predicts immune age changes.

The paper introduces a high-throughput microfluidic assay to study gametogenic rejuvenation in yeast and identifies Atg39 and Atg40 as molecular determinants of lifespan resetting.

The paper introduces PathStAR, a framework to quantify structural aging from histopathology images, revealing tissue-specific aging trajectories and coordinated deterioration across organs.

This study shows lactate extends C. elegans lifespan via redox-driven lipid remodeling and involves SIRT1 and RICTOR.

This study presents a longitudinal assessment of age-related changes in Brown-Norway rat physiology and histopathology at 6, 17, and 27 months of age to provide healthspan parameters for aging research.

This study identifies T13F2.2 as a critical gene in C. elegans that affects chromatin structure, autophagy, and lifespan through RNAi depletion and transcriptomic analysis.

This study shows that a glucose-rich diet in C. elegans causes neuron morphology issues and egg-laying defects, which are linked to serotonin signaling and the DAF16/FOXO pathway.

This study shows that DREAM complex activity influences somatic mutation burden, lifespan, and age-related disease, with reduced activity linked to longer lifespan and lower disease risk.

The paper shows that adjusting extracellular pH to prevent acidification extends yeast lifespan by enhancing the heat shock response and promoting polyQ aggregation.

The paper shows that differences in stress resistance and gut microbiome composition between Drosophila reference lines affect disease modeling outcomes in neurodegenerative conditions.

This study identifies H3K27ac as a key transcriptional switch that promotes longevity by enhancing lipid catabolism and antioxidant defenses under hormetic nutrient stress in C. elegans.

This study identifies InsP3R signaling as a mediator of mitochondrial stress-induced longevity in C. elegans through actomyosin-dependent mitochondrial dynamics.

The paper introduces a minimal model of aging that predicts two regimes and guides intervention strategies for extending healthspan and lifespan.

This study shows that Reserpine extends lifespan in Drosophila but reduces heat-stress resilience, revealing a trade-off between longevity and stress response.

This study identifies molecular signatures of aging in the mouse brain through proteo-transcriptomic analysis, revealing changes in protein aggregation, mRNA relocalization, and translation efficiency linked to neurodegeneration.

The paper shows that gut microbiota in Drosophila affect ageing through Acetobacter, Tachykinin, and TkR99D, extending lifespan without reducing fecundity.

This study shows that autophagy gene knockdown in C. elegans affects lifespan in a highly condition-dependent manner, with variable outcomes based on genetic background, temperature, and experimental conditions.

The paper introduces SkeletAge, a bulk RNA-seq-based aging clock that identifies 26 novel genes in skeletal muscle aging and links them to aging phenotypes and drug targets.

This study expresses a naked mole-rat HA synthase 2 transgene in mice, finding improved healthspan but no reduction in age-related hearing loss.

This paper identifies NHR-49 as a regulator of oocyte activation and ovulation in C. elegans, linking fertility, resource allocation, and longevity through its role in controlling GSA-1 expression.

This study examines age-related increases in infection susceptibility in Drosophila melanogaster, finding that susceptibility rises early in life and is linked to reduced tolerance rather than resistance, with distinct effects on male lifespan.

This study shows dietary zinc and protein-to-carbohydrate ratio interact to regulate reproduction and lifespan in Drosophila, with Zn having effects comparable to macronutrient adjustments.

The paper identifies compounds that extend mouse lifespan and healthspan using a biomarker-driven platform integrating gene expression, chemical screening, and lifespan studies.

The paper identifies a UPRmt modulator, fipp-1/FIP1L1, that extends lifespan in C. elegans and is associated with metabolic homeostasis in humans.

This study shows that daf-16/FOXO activity before dauer diapause enables dauer exit and post-dauer development by promoting cholesterol retention and DAF-12 ligand synthesis.

This study shows that dietary restriction extends lifespan in C. elegans by suppressing fertility, not through adaptive hypotheses, and suggests mutation accumulation drives this evolutionary effect.