Neuroinflammation and Neurodegeneration Mechanisms

This study shows that microglial inflammatory activation improves glucose tolerance during diet-induced obesity, independent of body weight changes.

This study shows that TN activates ipsilateral hippocampal microglia, leading to anxiodepressive behaviors and LTP impairment via IL-1β and P2X7R.

This study shows that TNF affects excitatory and inhibitory neurotransmission differently at low and high concentrations, with high concentrations activating microglia and inducing homeostatic effects.

The paper investigates how microglia change their phenotype in acute brain slices and how these changes affect neuronal network activity.

This study shows that hypothyroidism in mice leads to glial activation and spatial memory deficits, with differences in neuroinflammatory responses between mouse strains.

This study identifies SPP1 as a key mediator of microglial synaptic engulfment in Alzheimer's disease models, showing its role in neuroimmune interactions.

Microglia selectively engulf synapses in Alzheimer-like mouse brains via PtdSer-TREM2 signaling.

The paper identifies interferon-responsive oligodendrocytes in aging white matter linked to T cells and shows their role in white matter pathology.

This study shows that activating PIEZO1 channels in microglia improves amyloid beta clearance in AD models by enhancing survival, phagocytosis, and lysosomal activity.

This study shows that blocking P2Y12 in microglia prevents stress-induced synapse loss and behavioral deficits in male mice.

This study identifies Trx80 as a neuron-derived peptide that modulates microglia interferon response via Trem2-dependent mechanisms in Alzheimer's disease models.

This study examines the efficacy of PLX5622 in eliminating microglia in adult rat brains, finding significant sex differences in its effectiveness across brain regions.

This study shows that reducing Csf3 in Csf1r+/- mice improves anxiety, motor coordination, and social interaction but not cognitive deficits, and reduces microglial activation in the cerebellum.

The paper shows microglial TNFα regulates GABAAR plasticity, sleep slow waves, and memory consolidation through purinergic signaling.

This study shows that neutrophils in the meninges affect cognitive and social behaviors in mice, and their depletion triggers compensatory proliferation in response to specific stimuli.

The paper shows that Trem2 gene expression in microglia is upregulated only when they contact plaques, and this effect is reduced by the Trem2R47H mutation.

This study shows that microglial complement signaling regulates astrocyte pruning and vascular development in the retina.

MicrogliaST is a web server that analyzes spatiotemporal patterns of microglia in normal and disordered brains using single-cell transcriptomic data.

This study examines how Alzheimer's and Dementia with Lewy Bodies pathologies influence microglia responses in hippocampal subfields, finding distinct patterns in disease severity and microglial morphology.

The paper uses single-cell RNA sequencing to analyze microglial transcriptomic diversity in subarachnoid hemorrhage, identifying distinct subgroups and their roles in neuroinflammation.

This study shows that prenatal immune stress leads to long-term reduced microglia activation, affecting striatal connectivity and neuronal function.

The paper develops a triple co-culture model of neurons, microglia, and astrocytes to study Alzheimer's disease, showing reduced inflammation and synaptic loss in response to Aβ.

The paper uses single-cell RNA sequencing to compare fetal brain microglia and Hofbauer cells, revealing shared transcriptional programs and sex-specific differences.

This study shows that TSPO regulates mitochondrial metabolism and phagocytosis in microglia, and that targeting mitochondrial HK could improve phagocytosis in Alzheimer's disease.

This study shows that intracellular Ca2+ activity is necessary for microglia migration after brain injury in zebrafish.

This study shows that inhibiting HDAC3 reduces pathological features of reactive astrocytes in vitro and in vivo, promoting neural protection in neurodegenerative diseases.

This study identifies type I interferon signaling as a key driver of memory impairment in Alzheimer's disease by promoting neuroinflammation and synaptic loss in a mouse model.

This study shows that spermidine reduces neuroinflammation and soluble amyloid beta in an Alzheimer's disease mouse model by targeting microglia and reducing inflammatory pathways.

This study shows that deleting p38-MAPK in myeloid cells reduces Aβ levels and improves cognitive function in APP-transgenic AD mice.