Adipose Tissue and Metabolism

Exploring a mathematical framework for quantifying cell size- dependent glucose uptake in adipocytes

The paper develops a mathematical framework to estimate insulin-stimulated glucose uptake per adipocyte, considering cell size dependence, and shows it slightly improves model-data agreement.

Iron uptake mediated by TFRC and secretion of transferrin types stimulate thermogenic activation in human adipocytes

The paper shows that TFRC-mediated iron uptake and transferrin secretion enhance thermogenic activation in human adipocytes by supporting mitochondrial function and oxygen consumption.

Nuclear Myosin 1 links genomic architecture to adipose tissue remodeling, metabolic inflammation and obesity in mice

This study shows NM1 regulates adipose tissue remodeling, metabolic inflammation, and obesity in mice by controlling chromatin accessibility and gene expression during adipogenesis.

Functional and metabolomic analyses of brown adipose tissue during cold-deacclimation reveal rapid adaptations in N-acetylated amino acid metabolism

This study examines metabolic changes in brown adipose tissue during cold deacclimation, identifying rapid adaptations in N-acetylated amino acid metabolism.

SOX9 is part of a combinatorial marker that reveals early development and embryological origins of the mouse brown adipose tissue depots

The paper identifies the embryonic origins of major mouse brown adipose tissue depots using SOX9 as a marker and models their developmental trajectory.

The malate aspartate shuttle supports thermogenic lipid mobilization in brown adipocytes

This study shows the malate aspartate shuttle supports lipid mobilization in brown adipocytes by regulating lipid homeostasis and thermogenesis.

Thiamine transporter 2 and Janus kinase 2 inhibitor, fedratinib suppresses thermogenic activation of human neck area-derived adipocytes

This study shows that fedratinib, a ThTr2 and JAK2 inhibitor, suppresses thermogenic activation in human adipocytes by reducing amino acid consumption and thermogenic gene expression.

Immune and psychogenic fever arise through UCP1-independent thermogenic mechanisms

This study shows that immune-induced and psychogenic fever occur without BAT thermogenesis, suggesting skeletal muscle as a potential contributor.

Cell-autonomous thermogenesis of macrophage alters its antibacterial function

This study shows that macrophages generate heat through a cell-autonomous mechanism, which reduces their antibacterial function in cold environments.

Dnmt3b deficiency in adipocyte progenitor cells ameliorates obesity in female mice

This study shows that deleting Dnmt3b in adipocyte progenitor cells reduces obesity and improves metabolic health in female mice but not males.

Single cell-resolved transcriptional dynamics of human subcutaneous adipose tissue during lifestyle- and bariatric surgery-induced weight loss

This study examines transcriptional changes in human adipose tissue during weight loss from lifestyle and bariatric surgery, showing significant remodeling and reduced inflammation.

Acyl-CoA Binding Protein in White and Brown Adipose Tissue is Dispensable for Systemic Energy Metabolism

This study shows that ACBP is not essential for adipose tissue function or systemic energy metabolism in mice, as knockout mice show no significant metabolic changes.

Strain-specific response to pharmacological cold mimicking in aging mice

This study examines how six aging mouse strains respond to menthol, a cold mimetic, showing strain-dependent effects on metabolism and thermogenesis.

Multimodal epigenetic and enhancer network remodeling shape the transcriptional landscape of beige adipocytes

The paper identifies epigenetic and enhancer network changes during beige adipocyte formation, linking them to transcriptional shifts and metabolic function.

Quantifying Adipose Tissue Thermogenesis Using Highly Sensitive Isothermal Microcalorimetry

This study defines optimal conditions for measuring adipose tissue thermogenesis using isothermal microcalorimetry across different tissue types and handling conditions.

Central activation of catecholamine-independent lipolysis drives the end-stage catabolism of all adipose tissues

The paper identifies a catecholamine-independent lipolysis pathway activated by hypoglycemia and hypoinsulinemia that enables catabolism of stable adipose tissues.

Adipocyte Leptin Signaling Regulates Glycemia and Cardiovascular Function via Enhancing Brown Adipose Tissue Thermogenesis in Obese Male Mice.

This study shows that restoring leptin signaling in adipocytes of obese male mice improves BAT thermogenesis, glycemic control, and cardiovascular health, but not in females.

Acute deletion of PLIN5 in brown adipocytes causes mitochondrial dysfunction and cold intolerance

Diet and temperature interactively impact brown adipose tissue gene regulation controlled by DNA methylation

This study identifies diet-temperature interactions that shape DNA methylation and gene regulation in brown adipose tissue, showing obesity limits cold-induced transcriptional responses.

In vitro model of human subcutaneous adipocyte spheroids for studying mitochondrial dysfunction and mitochondria activating compounds

The paper develops an in vitro model of human subcutaneous adipocyte spheroids to study mitochondrial dysfunction and test mitochondria-activating compounds in obesity.

Free fatty acids increase basal glucose uptake by adipocytes leveling it to insulin stimulated uptake

This study shows that free fatty acids increase basal glucose uptake in adipocytes through GLUT4 translocation, but do not affect insulin-stimulated uptake, suggesting a context-dependent role in insulin resistance.

Mapping the Glycogen Synthase 1 Interactome in Brown Adipocytes

The paper identifies the GYS1 interactome in brown adipocytes using proximity labeling, revealing novel interactors and broader functional roles beyond glycogen synthesis.

Sex-specific thermoregulatory effects of estrogen signaling in Reprimo lineage cells

This study shows estrogen signaling in Reprimo lineage cells affects thermoregulation in female mice by altering brown adipose tissue thermogenesis, but not in males.

Bioenergetic responses to β-adrenergic stimulation in beige adipocyte depend on actomyosin driven forces

The paper identifies a biomechanical pathway in beige adipocytes that mediates thermogenic activation through Myh9-FAK signaling, distinct from white adipocytes.

An ultrasound-guided biopsy technique for obtaining supraclavicular brown fat biopsies and preadipocytes

This paper describes an ultrasound-guided biopsy technique to collect supraclavicular brown fat and subcutaneous white fat from healthy individuals, and evaluates in vitro differentiation and gene expression of progenitor cells.

Transcriptomic Profiling of scWAT Reveals Reduced Lipid-Associated Macrophage Signatures in Long-Term Endurance- and Resistance-Trained Athletes

The paper analyzes scWAT transcriptomes of long-term trained and untrained adults, finding sex-specific molecular adaptations linked to metabolic health.

Ancestral tributyltin exposure produces male-specific brown adipose thermogenic dysregulatoin

This study shows that ancestral tributyltin exposure impairs male brown adipose thermogenic function, leading to increased fat accumulation and reduced mitochondrial capacity after high-fat diet.

Cold exposure induces the constitutively active thermogenic receptor, GPR3, via ERRα and ERRγ

The paper identifies ERRα and ERRγ as regulators of cold-induced GPR3 expression in adipocytes, showing their role in thermogenic energy expenditure.

Brown Adipose Tissue and Skeletal Muscle Coordinately Contribute to Thermogenesis in Mice

This study shows that skeletal muscle and brown adipose tissue work together in mice to maintain body temperature through thermogenesis, with muscle contraction impairing activating BAT thermogenesis.

TRIB2 couples UCP1 degradation to thermogenic adaptation and metabolic health

This study identifies a TRIB2 variant linked to thermogenic capacity and shows that TRIB2 promotes UCP1 degradation, affecting metabolic health and obesity resistance.