Adipose Tissue and Metabolism

Legacy Effects of Early β-Adrenergic Stimulation Program Adipose Plasticity and Confer Metabolic Resilience in Obesity

The paper shows that early β-adrenergic stimulation remodels adipose tissue in mice, leading to metabolic resilience against future obesity-induced insulin resistance.

Red bone marrow hosts metabolically active anucleate adipocytes that support hematopoiesis

The paper isolates and characterizes human regulatory bone marrow adipocytes, showing they are anucleate, metabolically active, and support hematopoiesis.

Adipocyte Pten Inhibition Improves Metabolic Health Associated with Expanded Lipid Storage Capacity and Reduced Inflammation

This study shows that inhibiting Pten in adipocytes improves metabolic health by increasing lipid storage, preserving function, and reducing inflammation.

Severely lipoatrophic mice are hypermetabolic and hyperthermic under thermoneutral conditions in part due to an enhanced liver de novo lipogenesis

This study shows that severely lipoatrophic mice are hypermetabolic and hyperthermic at 30°C due to enhanced liver de novo lipogenesis, independent of thyroid hormones or calcium cycling.

E4BP4 Safeguards Brown Fat Mitochondria from Obesity-Induced Fragmentation via Ceramide Repression

This study identifies E4BP4 as a transcriptional repressor that prevents obesity-induced mitochondrial fragmentation in brown fat by inhibiting ceramide synthesis, improving glucose homeostasis without weight loss.

Donor-matched iPSC model reveals context-dependent T2D genetic signals in fibro-adipogenic progenitors

The paper uses donor-matched iPSC-derived FAPs to show that T2D GWAS signals are enriched in adipogenic FAP subtypes under high-insulin exposure.

Copper Import via CTR1 Supports the β3-Adrenergic Thermogenic Program

This study shows that copper import via CTR1 supports the β3-adrenergic thermogenic program by enhancing mitochondrial oxidation and thermogenic capacity in adipose tissues.

Acute Sprint Exercise Transcriptome in Human Adipose Tissue: Associations with Growth Hormone

This study examines the effects of sprint exercise on adipose tissue gene expression and its association with growth hormone, finding GH-related gene expression changes linked to lipolysis.

Mitochondrial carrier SLC25A34 links clock, diet, and temperature control of interorganellar lipid cycling

This paper identifies SLC25A34 as a key regulator of interorganellar lipid cycling, integrating circadian rhythms, diet, and temperature to control thermogenic metabolism.

Primary Cilia Dysfunction in Brown Fat Results in Fatal Thermogenesis Failure in Neonatal Mice

This study shows that primary cilia in brown fat are essential for ketogenesis and thermogenesis, and their loss causes neonatal lethality in mice.

SOX8-USP7-PGC-1α axis enhances thermogenesis in brown adipocytes

This study identifies a SOX8-USP7-PGC-1α regulatory axis in brown adipocytes that enhances thermogenesis but also causes metabolic maladaptation with prolonged activation.

Role of brown adipose tissue-specific sympathetic and sensory innervations in menthol-induced energy-expending phenotype

This study investigates how menthol affects brown adipose tissue activation and energy expenditure through sympathetic and sensory innervations in mice.

Tirzepatide and Intermittent Cold Exposure Independently Improve Glucose Homeostasis in DIO Mice Housed at Thermoneutrality

This study examines the individual and combined effects of tirzepatide and intermittent cold exposure on glucose homeostasis and energy metabolism in diet-induced obese mice.

Quercetin Promotes Adipose Thermogenesis and Metabolic Health

This study shows quercetin enhances thermogenesis in brown adipocytes by upregulating UCP1 and activates the COX2-PGE2-EP4-UCP1 signaling pathway, improving glucose and lipid metabolism.

A quantitative in vivo CRISPR-imaging platform identifies regulators of hyperplastic and hypertrophic adipose morphology in zebrafish

The paper develops a CRISPR-imaging platform in zebrafish to identify regulators of adipose morphology, finding distinct roles for Foxp1 paralogues in development and diet response.

Comparative analysis of naked mole-rat thermogenesis and its potential to maintain euthermia in response to cold

This study investigates the thermogenic potential of naked mole-rat brown adipose tissue and its ability to maintain body temperature in cold, finding that NMRs can initiate non-shivering thermogenesis but cannot sustain it due to heat loss and substrate limitations.

Inborn cardiorespiratory fitness and exercise training modulate brown adipose tissue function and plasticity in early life

This study shows that early life exercise increases energy expenditure and BAT thermogenic capacity regardless of inborn fitness, while inborn fitness affects BAT proteome composition.

Adrβ2 in skeletal muscle cells is required for exercise-induced Pgc1α but not for metabolic benefits of exercise on diet-induced obesity

miR-10b-5p regulates adipocyte lineage commitment and adipogenesis via targeting of Gata6 and Tubby.

This study identifies miR-10b-5p as a regulator of adipocyte differentiation by targeting Gata6 and Tubby, with distinct effects on white and brown adipogenesis.

Wnt/β-catenin signaling restrains developmental beiging and imprints long-term energy expenditure

This study identifies Wnt/β-catenin signaling as a brake on developmental beige adipocyte formation and shows its role in regulating long-term energy expenditure.

Slit3 Fragments Orchestrate Neurovascular Expansion and Thermogenesis in Brown Adipose Tissue

This study identifies Slit3 fragments that coordinate neurovascular expansion and thermogenesis in brown adipose tissue by regulating angiogenesis and sympathetic innervation.

Ca2+ influx through ER-plasma membrane contacts is required for brown fat thermogenesis and metabolic health

This study identifies ER-PM contacts and STIM-mediated SOCE as essential for brown fat thermogenesis and metabolic health during cold exposure.

Impaired adipose anabolism in pancreatic cancer cachexia is reversed by HuR inhibition

This study identifies impaired adipose anabolism in pancreatic cancer cachexia and shows that HuR inhibition restores adipose anabolism in mice.

Multi-omic responses to acute exercise in abdominal subcutaneous adipose tissue of sedentary adults: findings from MoTrPAC

The paper profiles multi-omic changes in abdominal subcutaneous adipose tissue after acute exercise in sedentary adults, identifying distinct molecular programs and candidate exerkines.

Transient SUMOylation Inhibition In Human Pre-adipocytes Stably Imprints a Transcriptional Beiging Fate

The paper shows that transient SUMOylation inhibition in human pre-adipocytes leads to stable beige differentiation when combined with PPARG activation.

Chronic cold exposure induces plasticity of mitochondrial calcium uptake in beige and brown fat of UCP1-deficient mice.

This study shows that UCP1-deficient mice adapt to cold by increasing mitochondrial calcium uptake via MCU, enhancing thermogenesis without UCP1.

Dietary sulfur amino acid restriction elicits a cold-like transcriptional response in inguinal but not epididymal white adipose tissue of male mice

The paper examines how dietary sulfur amino acid restriction and cold exposure affect energy expenditure and transcriptomic responses in different adipose tissues of male mice.

From Brown to White: Brown Adipose Tissue Endothelial Cells whiten in Culture Conditions

This paper isolates and cultures endothelial cells from brown and white adipose tissue, showing that brown adipose tissue endothelial cells lose their identity in culture and adopt features of white adipose and lymphatic endothelial cells.

Endothelial deletion of ADGRF5 (GPR116) promotes fibro-inflammatory EndMT and impairs adaptive thermogenesis in brown adipose tissue

This study shows that deleting Adgrf5 in endothelial cells of brown adipose tissue impairs thermogenic capacity during prolonged cold exposure by inducing EndMT and fibro-inflammatory changes.

Impaired non-shivering thermogenesis in the desert-dwelling antelope ground squirrel

This study investigates the thermogenic adaptations of antelope ground squirrels by analyzing their genome and transcriptome under cold exposure, revealing a shift toward shivering thermogenesis.