Prenatal Substance Exposure Effects

Gestational Ethanol Exposure Induces Sex-specific Striatal Acetylcholine and Dopamine Deficits

This study shows that gestational ethanol exposure in mice causes sex-specific striatal deficits in acetylcholine and dopamine function, linked to impaired motor learning and altered receptor modulation.

Perinatal Oxycodone Exposure Causes Long Term Sex-Dependent Changes in Sensory and Reward Processing in Adult Mice

This study compares long-term effects of in utero versus continued postnatal oxycodone exposure in mice, finding sex-dependent changes in sensory and reward processing but no major behavioral deficits.

Alterations in excitatory and inhibitory synaptic development within the mesolimbic dopamine pathway in a mouse model of prenatal drug exposure

This study examines the effects of prenatal drug exposure on synaptogenesis in the mesolimbic dopamine pathway in mice, finding increased excitatory and decreased inhibitory synapses in specific brain regions.

Sex differences in behavioral and brainstem transcriptomic neuroadaptations following neonatal opioid exposure in outbred mice

This study investigates sex differences in behavioral and brainstem transcriptomic changes in mice exposed to neonatal opioids, finding sex-specific neuroadaptations linked to NOWS-like behaviors.

Pre-Implantation Alcohol Exposure Induces Lasting Sex-Specific DNA Methylation Programming Errors in the Developing Forebrain

This study shows that pre-implantation alcohol exposure causes sex-specific DNA methylation errors in fetal mouse forebrains, potentially contributing to FASD-related neurodevelopmental issues.

Environmental enrichment mitigatesthe long-lasting sequelae of perinatal fentanyl exposure

This study shows that environmental enrichment can reverse behavioral and synaptic deficits caused by perinatal fentanyl exposure in mice.

Developmental Alcohol Exposure in Drosophila: Effects on Adult Phenotypes and Gene Expression in the Brain

This study examines the effects of developmental alcohol exposure on adult Drosophila phenotypes and brain gene expression, revealing sexual dimorphism and similarities to cocaine-induced gene expression changes.

Cannabidiol attenuates cognitive deficits and neuroinflammation induced by early alcohol exposure in a mice model.

This study shows that cannabidiol treatment during peri-adolescence improves cognitive deficits and reduces neuroinflammation in a mouse model of fetal alcohol spectrum disorder.

White Matter Alterations in Young Children with Prenatal Alcohol Exposure

This study identifies white matter microstructural differences in young children with prenatal alcohol exposure compared to controls using diffusion tensor imaging.

Prenatal Methadone Exposure Disrupts Behavioral Development and Alters Motor Neuron Intrinsic Properties and Local Circuitry

This study examines the effects of prenatal methadone exposure on mouse offspring, finding impairments in physical growth, sensorimotor behavior, and motor neuron function.

Transcriptomic changes due to early, chronic ethanol exposure during cortical development implicates arealization, cell-type specification, Axon Guidance and Synaptogenesis as primary determinants of Fetal Alcohol Spectrum Disorders

This study identifies transcriptomic changes in cortical neurons exposed to early chronic ethanol, highlighting altered pathways and a caudal molecular shift associated with FASD.

Moderate prenatal ethanol exposure increases total length of L1 axons in E15.5 mice

The paper investigates the effects of moderate prenatal ethanol exposure on axon development in E15.5 mice, finding increased L1+ axon length.

Ontogenetic Oxycodone Exposure Affects Early-Life Communicative Behaviors, Sensorimotor Reflexes, and Weight Trajectory in Mice

This study examines the effects of in utero and postnatal oxycodone exposure on mouse behavior and development, finding sex-dependent weight changes, altered vocalizations, and sensorimotor delays.

Prenatal THC does not affect female mesolimbic dopaminergic system in preadolescent rats

This study shows that prenatal THC exposure does not alter mesolimbic dopamine function or behavior in female rats, unlike males.

Perinatal fentanyl exposure leads to long-lasting impairments in somatosensory circuit function and behavior

This study shows that perinatal fentanyl exposure causes long-term impairments in somatosensory function and behavior in mice, with changes in synaptic and morphological properties.

Enhancement of parvalbumin interneuron-mediated neurotransmission in the retrosplenial cortex of adolescent mice following third trimester-equivalent ethanol exposure

This study examines the effects of neonatal ethanol exposure on GABAergic neurotransmission in the retrosplenial cortex of adolescent mice, finding altered parvalbumin interneuron function.

Maternal cannabis vapor exposure causes long-term alterations in emotional reactivity, social behavior, and behavioral flexibility in offspring.

This study shows that prenatal cannabis vapor exposure in rats leads to long-term behavioral changes in offspring, including altered emotional reactivity, social behavior, and cognitive flexibility.

Application of deep neural network reveals novel effects of maternal pre-conception exposure to nicotine on rat pup behavior

A deep neural network identifies novel behavioral effects of maternal nicotine exposure on rat pups, revealing altered motor development and movement patterns.

Gene-environment interactions characterized by single embryo transcriptomics

The paper investigates gene-environment interactions in zebrafish embryos, showing ethanol interacts with vangl2 and Shh pathways to cause midfacial defects.

Increased Ethanol Intake is Associated with Social Anxiety in Offspring Exposed to Ethanol on Gestational Day 12

This study shows that prenatal ethanol exposure affects social anxiety and ethanol intake differently in male and female offspring, with high social anxiety linked to increased ethanol consumption.

Hippocampal transcriptome analysis following maternal separation implicates altered RNA processing in a mouse model of fetal alcohol spectrum disorder

The paper investigates hippocampal gene expression changes in a mouse model of FASD following prenatal alcohol exposure and maternal separation, identifying altered RNA processing as a potential mechanism for anxiety-like behavior.

Enduring consequences of perinatal fentanyl exposure in mice

This study shows that perinatal fentanyl exposure in mice leads to somatic withdrawal and lifelong neurobehavioral changes similar to human neonatal opioid withdrawal syndrome.

Moderate episodic prenatal alcohol does not impact female offspring fertility in rats

This study finds that moderate episodic prenatal alcohol exposure in rats does not significantly affect female offspring fertility parameters.

Brain-wide genetic mapping identifies the indusium griseum as a prenatal and shared target of pharmacologically-unrelated psychostimulants

The paper identifies the indusium griseum as a prenatal target of psychostimulants and shows that Scgn+/Vglut1+ neurons in this region are critical for neuronal excitability and linked to behavioral abnormalities.

Prenatal alcohol exposure disrupts Shh pathway and primary cilia genes in the mouse neural tube

This study shows that prenatal alcohol exposure disrupts the Shh pathway and primary cilia in mouse neural tube, suggesting a transient ciliopathy as a mechanism for alcohol-related birth defects.

Prenatal alcohol exposure programs offspring disease: Insulin resistance in adult males in a rat model of acute exposure

This study examines the effects of acute prenatal alcohol exposure on glucose metabolism and insulin resistance in male rat offspring, finding sex-specific metabolic dysfunction.

The NKCC1 antagonist bumetanide mitigates interneuronopathy associated with ethanol exposure In utero

This study shows that bumetanide, an NKCC1 antagonist, prevents ethanol-induced interneuronopathy and behavioral deficits in a FASD model.

The Effects of Alcohol and Cannabinoid Exposure during the Brain Growth Spurt on Behavioral Development in Rats

This study examines the behavioral effects of prenatal exposure to ethanol and cannabis in rats, finding additive negative impacts on activity and spatial learning.

Altered cortical brain structure and increased risk for disease seen decades after perinatal exposure to maternal smoking: A study of 9,000 adults in the UK Biobank

This study finds that perinatal exposure to maternal smoking is associated with reduced cortical surface area in specific brain regions and increased disease risk in middle-aged and older adults.

Altered Motor Development Following Late Gestational Alcohol and Cannabinoid Exposure in Rats

This study examines the effects of prenatal cannabis and alcohol exposure on motor development in rats, finding that cannabis alone can alter development and worsen alcohol-related impairments in females.