Protein Tyrosine Phosphatases

Reversible control of kinase signaling through chemical-induced dephosphorylation

This study uses an ABA-induced proximity system to reversibly control kinase signaling by recruiting phosphatases, revealing how phosphatases regulate oncogenic kinases like BCR::ABL1, BRAF(V600E), and MEK1.

A conserved protein tyrosine phosphatase, PTPN-22, functions in diverse developmental processes in C. elegans

This study identifies novel functions of the conserved phosphatase PTPN-22 in C. elegans, showing its role in molting, cell adhesion, and cytoskeletal regulation through genetic and proteomic analyses.

Unraveling the role of receptor-like protein tyrosine phosphatase PTPRH in cell signaling regulation and biological processes of non-small cell lung cancer

This study identifies PTPRH's role in NSCLC by revealing its interactions and signaling effects, showing it suppresses tumor growth and migration.

In vivo Targeting MEK and TNK2/SRC pathways in PTPN11 driven leukemia

This study shows that combining MEK and TNK2/SRC inhibitors effectively treats PTPN11-mutant leukemias in mouse models and patient-derived xenografts.

Targeting protein tyrosine phosphatase non-receptor type 2 with a novel inhibitor for AML therapy

This study identifies PTPN2 as a therapeutic target in AML, discovers a selective inhibitor K73, and demonstrates its efficacy in reducing AML burden in vitro and in vivo.

Catalytically inactive SHP1-C453S mutant gain of "robust LLPS" function

The paper shows that the SHP1-C453S mutant, which lacks catalytic activity, has enhanced liquid-liquid phase separation (LLPS) ability, suggesting a link between conformational changes and LLPS.

Cardiomyocyte-specific deletion of PTP1B protects against HFD-induced cardiomyopathy through direct regulation of cardiac metabolic signaling

This study shows that deleting PTP1B in cardiomyocytes protects against high-fat diet-induced heart disease by promoting fatty acid metabolism and reducing glucose metabolism through a novel PTP1B/PKM2/AMPK axis.

Loss of Shp1 impairs myeloid cell function and causes lethal inflammation in zebrafish larvae

This study shows that loss of Shp1 in zebrafish leads to myeloid cell dysfunction, inflammation, and larval lethality.

Molecular mechanism of Afadin substrate recruitment to the receptor phosphatase PTPRK via its pseudophosphatase domain

The paper identifies how Afadin is recruited to PTPRK via its pseudophosphatase domain, revealing that substrate specificity is determined by interactions outside the active site.

RPTPγ is a redox-regulated suppressor of promigratory EGFR signaling

The paper shows RPTPγ suppresses promigratory EGFR signaling by redox regulation, enabling phosphorylation responses to low EGF levels while blocking spontaneous signaling.

Inflammatory response in hematopoietic stem and progenitor cells triggered by activating SHP2 mutations evokes blood defects

This study identifies an inflammatory response in HSPCs with SHP2 mutations that drives MPN and suggests anti-inflammatory agents as potential therapies for JMML.

A spatially resolved EGFR signaling model predicts the length scale of GAB1-SHP2 complex persistence

The paper develops a reaction-diffusion model to predict the spatial persistence of GAB1-SHP2 complexes downstream of EGFR activation and validates it with experiments.

Reduced PTPRD expression differentially alters brain phosphotyrosine phosphoproteomic profiles of 2 and 12 month-old mice

The paper investigates how PTPRD expression levels affect phosphotyrosine phosphoproteomic profiles in young and aged mice brains, identifying potential substrates and functional implications.

Molecular basis for substrate specificity of the Phactr1/PP1 phosphatase holoenzyme

The paper identifies the molecular mechanism by which Phactr1/PP1 phosphatase achieves substrate specificity through structural and phosphoproteomic analysis.

CoralP: Flexible visualization of the human phosphatome

CoralP provides an interactive web tool for visualizing human phosphatome data with customizable attributes, offering a unique resource for phosphatase analysis.

Mesenchymal expression of activated K-ras yields Noonan Syndrome-like bone defects that are rescued by mid-gestational MEK inhibition.

This paper generates a mouse model with activated K-ras in mesenchymal progenitors to study Noonan Syndrome-like bone defects and shows that MEK inhibition during mid-gestation rescues these defects.

Assessing the Gene-Disease Association of 19 Genes with the RASopathies using the ClinGen Gene Curation Framework

The paper curates and scores gene-disease associations for 19 genes related to RASopathies using the ClinGen framework, classifying their associations as definitive, strong, moderate, limited, disputed, or no evidence.

Interdependence of EGFR with PTPs on juxtaposed membranes generates a growth factor sensing and responding network

The paper identifies how EGFR interacts with PTPs on juxtaposed membranes to create a network that senses and responds to growth factor signals.

Analysis of the human kinome and phosphatome reveals diseased signaling networks induced by overexpression

The paper analyzes the human kinome and phosphatome to identify signaling networks altered by protein overexpression, revealing novel relationships and mechanisms of cancer progression.

Rules for PP2A-controlled phosphosignalling and drug responses

The paper presents a systemic analysis of PP2A-regulated phosphosignaling and drug responses, revealing rules for phosphoregulation and cancer therapy classification.

A protein phosphatase network controls temporal and spatial dynamics of differentiation commitment in human epidermis

In suspended human keratinocytes, five induced phosphatases dampen ERK to drive differentiation commitment, opposed by DUSP10, in a time-rewired network that renders commitment an unstable switch.