Author
University of Pittsburgh
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
72 papers
Recent·Most cited
W.-T. He, X. Hou, J. Zhao, J. Sun, H. He, W. Si, J. Wang, Z. Jiang, Z. Yan, G. Xing, M. Lu, M. A. Suchard, X. Ji, W. Gong, B. He, , S. Su
The paper characterizes the virome of 1725 game animals in China, identifying 71 mammalian viruses, 45 novel, and highlighting potential zoonotic risks.
bioRxiv · Nov 10, 2021 · PreprintZoology
L. Fan, Q. Pan, W. Yang, S. C. Koo, C. Tian, L. Li, M. Lu, A. Brown, B. Ju, J. Easton, S. Ranganathan, S. Shin, A. Bondoc, J. J. Yang, J. Yu, L. Zhu
This study identifies a neonatal liver niche that promotes hepatoblastoma metastasis via the Cxcl1/Cxcr2 axis, showing increased tumor aggressiveness and hypoxia in early postnatal models.
bioRxiv · Oct 22, 2021Cancer Biology
Z. Yang, Y. Han, S. Ding, A. Finzi, W. Mothes, M. Lu
This study uses smFRET to show SARS-CoV-2 variants have more open Spike conformations and slower transitions, increasing their stability and transmission efficiency.
bioRxiv · Oct 11, 2021 · PreprintMicrobiology
M. Eltobgy, A. Zani, A. Kenney, S. Estfanous, E. Kim, A. Badr, C. Carafice, K. Daily, O. Whitham, M. Pietrzak, A. Webb, J. Kawahara, A. Eddy, P. Denz, M. Lu, , A. Amer
This study shows that caspase-4/11 worsens SARS-CoV-2 infection by increasing inflammation and thrombosis, independent of GSDMD, suggesting it as a potential drug target for severe COVID-19.
bioRxiv · Sep 24, 2021Immunology
P. Parutto, J. Heck, M. Lu, C. F. Kaminski, M. Heine, E. Avezov, D. Holcman
This paper introduces a computational method to analyze high-throughput super-resolution single-particle trajectories, enabling reconstruction of organelle dynamics and membrane reorganization.
bioRxiv · Sep 18, 2021 · PreprintCell Biology
Y. Wang, Y. Yu, L. Li, M. Zheng, J. Zhou, H. Gong, B. Feng, J. Qu, Z. Li, R. Ji, M. Lu, X. Yang, X. Zuo, S. Li, Y. Li
The paper creates a regional cell atlas of human intestine using single-cell RNA sequencing and spatial transcriptomics, revealing how microenvironment shapes immune surveillance and disease susceptibility.
bioRxiv · Sep 13, 2021 · PreprintCell Biology
W. Mothes, W. Li, Y. Chen, J. Prevost, I. Ullah, M. Lu, S. Y. Gong, A. Tauzin, R. Gasser, D. Vezina, S. P. Anand, G. Goyette, D. Chaterjee, S. Ding, W. D. Tolbert, , A. Finzi
This study characterizes two SARS-CoV-2 antibodies effective against variants, showing their structural basis and mechanisms of neutralization.
bioRxiv · Aug 2, 2021Microbiology
B. Zou, M. Goodwin, D. Saleem, W. Jiang, J. Tang, Y. Chu, R. S. Munford, M. Lu
This study identifies AOAH as a lipase that deacylates oxidized phospholipids, reducing inflammation and acute lung injury in vivo.
bioRxiv · Jul 26, 2021Immunology
J. Qian, C. Wang, B. Wang, C. Li, K. Fu, Y. Wang, Y. Gao, C. Niu, C. Zhao, J. Liu, L. Wang, R. Liu, F. Luo, M. Lu, Y. Liu, Y. Chu
The paper uses single-cell sequencing to analyze glioma-associated microglia and macrophages, revealing their distinct roles in tumor progression and clinical outcomes.
bioRxiv · Jul 11, 2021 · PreprintImmunology
J. Wu, B. Liang, Y. Fang, H. Wang, X. Yang, S. Shen, L. Chen, S. Li, S. Lu, T. Xiang, J. Liu, V. T. K. Le-Trilling, M. Lu, D. Yang, F. Deng, , X. Zheng
The study compares antibody responses in asymptomatic and symptomatic SARS-CoV-2感染者, finding that symptomatic individuals maintain higher and longer-lasting IgG and neutralizing capacities.
bioRxiv · Mar 26, 2021Immunology
I. Ullah, J. Prevost, M. S. Ladinsky, H. Stone, M. Lu, S. P. Anand, G. Beaudoin-Bussieres, K. Symmes, M. Benlarbi, S. Ding, R. Gasser, C. Fink, Y. Chen, A. Tauzin, G. Goyette, , P. D. Uchil
This study uses live imaging to show that neutralizing antibodies against SARS-CoV-2 need both Fab and Fc functions to effectively prevent and resolve infection in mice.
bioRxiv · Mar 22, 2021Immunology
A. Tauzin, M. Nayrac, M. Benlarbi, S. Y. Gong, R. Gasser, G. Beaudoin-Bussieres, N. Brassard, A. Laumaea, D. Vezina, J. Prevost, S. P. Anand, C. Bourassa, G. Gendron-Lepage, H. Medjahed, G. Goyette, , A. Finzi
This study shows a single dose of the BNT162b2 mRNA vaccine elicits strong antibody and T cell responses, including Fc-mediated effector functions, and boosts pre-existing immunity in previously infected individuals.
bioRxiv · Mar 18, 2021 · PreprintImmunology
This study examines how beta diversity responds to dispersal in meta-community models, finding a hump-shaped relationship influenced by local dispersal, non-neutrality, and biotic interactions.
bioRxiv · Feb 19, 2021 · PreprintEcology
M. Lu, D. Schneider, R. Daniel
The paper screens metagenomes for lipolytic genes using function-driven and sequence-based methods, revealing ecological factors influence their distribution.
bioRxiv · Feb 1, 2021Microbiology
L. Qiu, Q. Wu, X. Wang, G. Zhuang, J. Han, H. Wang, Z. Shang, W. Tian, Z. Chen, Z. Lin, H. He, J. Hu, Q. Lv, J. Ren, J. Xu, , X. Ouyang
This paper introduces DEAS, a simulator that predicts crop latitude adaptation using florigen gene expression, enabling faster breeding for climate-resilient crops.
bioRxiv · Dec 9, 2020Plant Biology
This paper introduces a parametric framework for quantifying and comparing n-dimensional hypervolumes using multivariate normal distributions, enabling partitioning of niche variation components.
bioRxiv · Nov 21, 2020Ecology
M. Lu, L.-M. Gao, H.-T. Li, F. He
The paper analyzes patterns of vascular plant discoveries in China, finding that socio-economic factors and species traits influence discovery rates and that southwest China harbors the most undiscovered species.
bioRxiv · Nov 19, 2020Plant Biology
S. Xiong, D. Zhu, B. Liang, M. Li, W. Pan, J. He, H. Wang, S. Kathrin, D. Ulf, M. Lu, D. Liu, D. Yang, J. Liu, X. Zheng
This study identifies immune markers, including HLA-DR and CTLA-4 expression on CD4 T cells, that predict HBsAg loss in chronic hepatitis B patients.
bioRxiv · Nov 16, 2020Microbiology
Z. Li, J. Liu, H. Deng, X. Yang, H. Wang, X. Feng, G. Zelinskyy, M. Trilling, K. Sutter, M. Lu, B. Wang, D. Yang, X. Zheng, J. Liu
This study shows that SARS-CoV-2-specific T cell memory persists for at least 9 months in most convalescent COVID-19 individuals, with some responses lasting longer.
bioRxiv · Nov 15, 2020 · PreprintMicrobiology
M. Lu, P. D. Uchil, W. Li, D. Zheng, D. S. Terry, J. Gorman, W. Shi, B. Zhang, T. Zhou, S. Ding, R. Gasser, J. Prevost, G. Beaudoin-Bussieres, S. P. Anand, A. Laumaea, , W. Mothes
This study uses smFRET to observe real-time conformational dynamics of SARS-CoV-2 spikes on virus particles, revealing multiple states and mechanisms of neutralization by antibodies and convalescent plasma.
bioRxiv · Sep 10, 2020Microbiology
J. Westmeier, K. Paniskaki, Z. Karaköse, T. Werner, K. Sutter, S. Dolff, M. Overbeck, A. Limmer, J. Liu, X. Zheng, T. Brenner, M. M. Berger, O. Witzke, M. Trilling, M. Lu, , G. Zelinskyy
This study examines CD8+ T cell cytotoxicity in mild COVID-19 patients, finding reduced cytotoxic potential in elderly individuals over 80 years old.
bioRxiv · Aug 21, 2020Immunology
A. D. Stephens, M. Lu, G. S. Kaminski Schierle
This paper presents a rapid protocol for purifying monomeric recombinant Aβ from E. coli and fluorescent Aβ-mCherry from mammalian cells, avoiding aggregation and freeze-drying steps.
bioRxiv · May 13, 2020Biophysics
R. Ibrahim, A. Gopal, M. Fuller, P. Umlandt, L. Chang, J. Wegrzyn-Woltosz, J. Lam, J. Li, M. Lu, J. Parker, A. Karsan
This paper identifies TIRAP as a driver of myelosuppression through an Ifnγ-Hmgb1 axis that disrupts the bone marrow microenvironment, independent of T cell function or pyroptosis.
bioRxiv · Feb 26, 2020Cancer Biology
H. Huang, J. Liu, M. Rückborn, V. T. K. Le-Trilling, D. Zhu, S. Yang, W. Zhou, X. Yang, X. Feng, Y. Lu, M. Lu, U. Dittmer, D. Yang, M. Trilling
This study shows that HBV vaccines based on modified CMV vectors can clear HBV in mice through enhanced CD8+ T cell responses in both prophylactic and therapeutic settings.
bioRxiv · Jan 29, 2020Immunology
H. I. Hamouda, N. Ali, H. Su, J. Feng, M. Lu, F.-L. Li
This paper characterizes two pectate lyases from Caldicellulosiruptor bescii, showing distinct degradation properties and roles of their CALG domain in plant biomass breakdown.
bioRxiv · Jan 16, 2020 · PreprintBiochemistry
M. Lu, F. W. van Tartwijk, J. Q. Lin, W. Nijenhuis, P. Parutto, M. Fantham, C. N. Christensen, E. Avezov, C. E. Holt, A. Tunnacliffe, D. Holcman, L. Kapitein, G. Kaminski Schierle, C. F. Kaminski
This study shows lysosomes actively regulate ER remodeling by repositioning, affecting ER tubule distribution and morphology in response to metabolic changes.
bioRxiv · Jan 15, 2020Cell Biology
C. Zhang, M. Lu, L. Lin, Z. Huang, R. Zhang, X. Wu, Y. Chen
This study identifies riboflavin as a direct mediator of electron transfer in microbial P450 monooxygenase dealkylation, revealing a novel mechanism involving FAD/FMN cofactors.
bioRxiv · Nov 13, 2019 · PreprintBiochemistry
R. Henderson, M. Lu, Y. Zhou, Z. Mu, R. Parks, Q. Han, A. L. Hsu, E. Carter, S. C. Blanchard, R. Edwards, K. Wiehe, K. O. Saunders, M. J. Borgnia, A. Bartesaghi, W. Mothes, , S. M. Alam
This study identifies a critical role for W571 in HIV-1 Env allostery by showing mutations disrupting CD4-induced rearrangements and rendering Env insensitive to CD4 binding.
bioRxiv · Nov 2, 2019Biochemistry