S. Wang

Therapy-associated remodeling of pancreatic cancer revealed by single-cell spatial transcriptomics and optimal transport analysis

This study uses single-cell spatial transcriptomics and optimal transport analysis to reveal therapy-induced changes in pancreatic cancer microenvironment interactions.

Hypogonadal (Gnrh1hpg) mice reveal niche-specific influence of reproductive axis and sex on intestinal microbial communities

This study uses hypogonadal mice to show sex and reproductive axis effects on intestinal microbial communities, with sex chromosomes also playing a role, and highlights limitations of fecal samples in reflecting small intestine diversity.

The TOR signaling pathway regulates vegetative development, aflatoxin biosynthesis, and pathogenicity in Aspergillus flavus

This study identifies and characterizes nine genes in the TOR signaling pathway of A. flavus, revealing their roles in growth, aflatoxin biosynthesis, and pathogenicity.

Comprehensive Characterization and Global Transcriptome Analyses of Human Fetal Liver Terminal Erythropoiesis

This study characterizes human fetal liver terminal erythropoiesis through RNA sequencing of primary and cultured erythroblasts and immortalized cell lines, revealing gene expression patterns and pathway changes associated with enucleation.

Targeting Ras signaling excitability in cancer cells through combined inhibition of FAK and PI3K

This study shows that combining FAK and PI3K inhibitors synergistically suppresses cervical and pancreatic cancer cell growth by increasing apoptosis and reducing mitosis.

Gut microbiota-derived gamma-aminobutyric acid from metformin treatment reduces hepatic ischemia/reperfusion injury through inhibiting ferroptosis

This study shows metformin reduces hepatic ischemia/reperfusion injury by altering gut microbiota to increase GABA, which inhibits ferroptosis.

ENPP1 is an innate immune checkpoint of the anticancer cGAMP-STING pathway

This study identifies ENPP1 as an innate immune checkpoint that suppresses the cGAMP-STING pathway, promoting tumor growth and metastasis, and shows that inhibiting its cGAMP hydrolase activity enhances cancer immunity.

RAPSYN-Mediated Neddylation of BCR-ABL Alternatively Determines the Fate of Philadelphia Chromosome-positive Leukemia

This study identifies RAPSYN-mediated neddylation of BCR-ABL as a mechanism driving Ph+ leukemia progression and presents it as a therapeutic target.

Cbl and Cbl-b Ubiquitin Ligases are Essential for Intestinal Epithelial Stem Cell Maintenance

This study shows that Cbl and Cbl-b ubiquitin ligases are essential for intestinal epithelial stem cell maintenance by regulating the Akt-mTOR pathway.

The microbiota of Amblyomma americanum reflects known westward expansion.

This study examines the microbiota of Amblyomma americanum ticks across different geographic regions and finds that microbiota structure varies between historical and western-expanded populations.

Visualizing the chaperone-mediated folding trajectory of the G protein β5 β-propeller

This study visualizes the chaperone-mediated folding trajectory of Gβ5 using cryo-EM, showing how CCT stabilizes intermediates to fold the β-propeller domain.

An isoform-resolution transcriptomic atlas of colorectal cancer from long-read single-cell sequencing

This study builds an isoform-resolution transcriptomic atlas of colorectal cancer using long-read single-cell sequencing and identifies neoepitopes for vaccine development.

Optogenetic control of kinesins -1, -2, -3, and dynein reveals their specific roles in vesicular transport

This study uses optogenetic inhibitors to investigate the roles of kinesins-1, -2, -3, and dynein in vesicular transport, revealing their specific contributions to endosome and lysosome motility.

Maintaining hypoxia environment of subchondral bone alleviates osteoarthritis progression

This study shows that inhibiting subchondral osteoclastogenesis maintains hypoxia in subchondral bone, slowing osteoarthritis progression by stabilizing HIF-1 and reducing cartilage degeneration.

High-level production of nervonic acid in the oleaginous yeast Yarrowia lipolytica by systematic metabolic engineering

This study engineered Yarrowia lipolytica to overproduce nervonic acid through metabolic pathway modifications, achieving high titers and purity.

Artificially cultivated duckweed: a high-efficiency starch producer

This paper reports a method to produce starch efficiently from duckweed under specific conditions and identifies mechanisms behind its high starch accumulation.

Duckweed evolution: from land back to water

This study investigates the reverse evolution of duckweed from land back to water, showing gradual degeneration in root structure, stomatal function, and lignocellulose content, along with gene pathway changes.

AN ARTIFICIAL INTELLIGENCE FOR RAPID IN-LINE LABEL-FREE HUMAN PLURIPOTENT STEM CELL COUNTING AND QUALITY ASSESSMENT

This paper develops an AI algorithm for counting and assessing human pluripotent stem cells in brightfield images, achieving high accuracy and efficiency.

Widespread readthrough events in plants reveal unprecedented plasticity of stop codons

The paper identifies widespread stop codon readthrough events in plants and reveals the plasticity of stop codons in encoding amino acids.

Taxonomic distribution of metabolic functions underpins nutrient cycling in Trichodesmium consortia

The study links microbial taxa and their functional traits to nutrient cycling in Trichodesmium consortia, revealing functional redundancy and interdependencies that enhance resilience in oligotrophic environments.

Potentiation of host defense through sRNA packaged in OMVs of Xanthomonas oryzae pv. oryzicola

This study identifies Xosr001, an sRNA packaged in OMVs of Xoc, as a mediator of stomatal immunity in rice by modulating OsJMT1 and MeJA levels.

Phage administration with repeated intravenous doses leads to faster phage clearance in mammalian hosts

This study evaluates phage clearance and host responses to repeated intravenous phage doses in rats and monkeys, finding faster clearance and immune activation with repeated administration.

Virus diversity and activity is driven by snowmelt and host dynamics in a high-altitude watershed soil ecosystem

This study examines viral diversity and activity in a high-altitude watershed soil ecosystem, revealing seasonal shifts in phage activity and virus-host dynamics linked to environmental and host factors.

Induction of T-DNA amplification by retrotransposon-derived sequences

This study shows that retrotransposon-derived sequences in T-DNA can amplify transgene copy number in Arabidopsis, increasing targeted mutagenesis and gene targeting frequency.

Spatiotemporal cell landscape of human embryonic tooth development

The paper maps the spatiotemporal cell landscape of human embryonic tooth development using single-cell RNA sequencing and spatial transcriptomics, identifying key cell types and regulatory networks.

Dying cell-released exosomal CXCL1 promotes breast cancer metastasis by activating TAM/PD-L1 signaling

This study shows that exosomal CXCL1 from dying breast cancer cells promotes metastasis by activating TAM/PD-L1 signaling and identifies TPCA-1 as a potential inhibitor.

Antibody-mediated cell entry of SARS-CoV-2

This study shows that certain monoclonal antibodies can replace ACE2 to mediate SARS-CoV-2 entry into cells, indicating that ACE2 is not essential for viral infection.

Ferroptosis is determined by chloride ions

This study identifies chloride ions as essential determinants of ferroptosis, showing that extracellular chloride levels influence lipid peroxidation and cell death.

Paradoxical activation of oncogenic signaling as a cancer treatment strategy

This study shows that inhibiting PP2A and WEE1 together can kill colon cancer cells by causing DNA replication collapse and cell death, and that resistance to this treatment suppresses tumor growth.

A novel cryopreservation and biobanking strategy to study lymphoid tissue stromal cells in human disease

This study demonstrates that cryopreservation of lymphoid tissue allows for the study of non-hematopoietic stromal cells in human disease, preserving cell type proportions and transcriptional profiles.