Rheumatoid Arthritis Research and Therapies

Housekeeping genes are enriched in rheumatoid arthritis-related genes

This study finds that housekeeping genes are significantly enriched in differentially expressed genes in rheumatoid arthritis, suggesting a potential role in RA pathogenesis.

Proteomic characterisation of the early rheumatoid arthritis-cardiovascular disease multimorbid axis.

This study identifies blood-based proteins associated with cardiovascular abnormalities in early rheumatoid arthritis using proteomic analysis and CMR imaging.

Characterisation of CD4 Th subsets as well as dietary, exercise and lifestyle factors in an established Rheumatoid Arthritis cohort; pilot study.

This study examines sex-specific differences in CD4 Th subsets and lifestyle factors in a RA cohort, finding sex-related variations in Th cell frequencies and dietary patterns.

Perivascular RELM-positive synovial macrophages recruit monocytes at the onset of inflammatory arthritis

The paper identifies RELM-positive perivascular macrophages that recruit monocytes to the synovium during arthritis onset, contributing to lining macrophage replenishment.

Multi-lineage transcriptional and cell communication signatures define evolving personalized mechanisms that initiate and perpetuate rheumatoid arthritis

The paper identifies shared transcriptional and cell communication signatures in RA patients and at-risk individuals, showing how multiple pathogenic mechanisms contribute to disease initiation and progression.

Formyl-peptide receptor type 2 activation mitigates secondary organ damage in inflammatory arthritis

This study shows that activating FPR2 with a small molecule agonist reduces cardiac and lung damage in arthritic mice by decreasing inflammation and fibrosis.

Super-omics and PCAS reveal tumor-like molecular landscape of rheumatoid arthritis

The paper uses super-omics and PCAS to identify tumor-like molecular features in RA, including key proteins and oncogenic pathways.

Targeting histone acetylation enables epigenetic modulation of inflammatory pathways, a novel therapeutic strategy for rheumatoid arthritis

This study screens histone acetylation inhibitors to modulate immune pathways in RA, showing concentration-dependent effects and overlap with existing RA drug pathways.

Generation of a T cell receptor, cytokine and cell repertoire synovial fluid atlas to define commonalities and dissimilarities between arthritic diseases through systems immunology approaches

The paper creates a synovial fluid TCR, cytokine, and cell repertoire atlas to compare disease mechanisms across arthritic conditions using systems immunology approaches.

Wnt signaling drives stromal inflammation in inflammatory arthritis

This study shows Wnt signaling drives inflammation in fibroblasts of inflammatory arthritis, suggesting it as a therapeutic target.

5' HOXD Genes Differentially Regulate Gene Expression of Synovial Fibroblasts in Hand Joints

The paper shows that HOXD13 regulates gene expression in synovial fibroblasts, influencing primary cilia function and joint-specific RA pathology.

The Ratchet Model of Synovial Flares in Palindromic Rheumatism

The paper uses an adapted ODE model to study synovial flares in palindromic rheumatism, showing how metastable locking can lead to progression to rheumatoid arthritis.

Distinct tissue-niche localization and function of synovial tissue myeloid DC subsets in health, and in active and remission Rheumatoid Arthritis

This study identifies distinct myeloid DC subsets in synovial tissue across health and RA states, showing their roles in inflammation and tolerance.

Opposing Regulation of TNF Responses by IFN-γ and a PGE2-cAMP Axis that is Apparent in Rheumatoid and Immune Checkpoint Inhibitor-induced Arthritis IL-1β+ Macrophages

This study identifies a PGE2-cAMP axis that opposes IFN-γ regulation of TNF responses in IL-1β+ macrophages in RA and ICI-arthritis, revealing a novel regulatory mechanism for inflammatory gene expression.

Spatial programming of fibroblasts promotes resolution of tissue inflammation through immune cell exclusion

The paper uses multi-omic spatial analysis to identify fibroblast subsets in inflamed synovium that create tissue niches influencing immune cell trafficking and inflammation resolution.

IL-6 and IL-27 negatively regulate CRTAM-expressing CD4+ T-cells associated with lymphoid-driven synovitis.

The paper identifies CRTAM-expressing CD4+ T-cells in lymphoid-driven synovitis and shows that IL-6 and IL-27 inhibit their activation through STAT3 and ZEB1.

Effectiveness of Exercise Intervention in Preventing Active Arthritis Exacerbation in an SKG Mouse Model of Rheumatoid Arthritis

This study shows that low-intensity exercise reduces arthritis severity and inflammation in SKG mice with rheumatoid arthritis.

PFS alleviates bone destruction in collagen-induced arthritis mice associated with macrophage polarization

This study shows that PFS reduces bone destruction and shifts macrophage polarization from M1 to M2 in arthritis mice, suggesting its potential as an RA treatment.

Joint-specific rheumatoid arthritis fibroblast-like synoviocyte regulation identified by integration of chromatin access and transcriptional activity

The paper identifies joint-specific regulatory patterns in rheumatoid arthritis fibroblast-like synoviocytes by integrating chromatin accessibility and transcriptional data, revealing differences in proliferation, migration, and inflammation between hand and non-hand joints.

Causal Relationship between Rheumatoid Arthritis and Atherosclerosis Risk: A Mendelian Randomized Study

This study uses Mendelian randomization to find a causal link between rheumatoid arthritis and increased atherosclerosis risk, with some specific arteries showing significant associations.

Gene Network Analyses Identify Co-regulated Transcription Factors and BACH1 as a Key Driver in Rheumatoid Arthritis Fibroblast-like Synoviocytes

The paper identifies co-regulated transcription factors and BACH1 as a key driver in RA FLS using gene network analyses and experimental validation.

Cell-Specific Gene Networks and Drivers in RheumatoidArthritis Synovial Tissues

The paper identifies cell-specific gene regulators and networks in RA synovial tissues using RNA-seq data and computational methods, revealing key transcription factors and pathways involved in disease.

A large-scale Boolean model of the Rheumatoid Arthritis Fibroblast-Like Synoviocytes predicts drug synergies in the arthritic joint

The paper develops a Boolean model of RA-FLS to predict drug synergies and identify therapeutic targets for rheumatoid arthritis.

Investigation of Association Between microRNA Variants and Risk of Rheumatoid Arthritis

This study investigates the association of specific microRNA variants with rheumatoid arthritis risk in a Pakistani population, finding significant association for rs6505162 but not rs11614913.

Graph deep learning reveals multiple signal pathways activated in anti-citrullinated protein antibodies stimulated synoviocytes

The paper uses graph deep learning to analyze single-cell mRNA data from ACPA-stimulated synoviocytes, identifying IL1-IL1R and PI3K/AKT signaling pathways.

Cellular deconstruction of inflamed synovium defines diverse inflammatory phenotypes in rheumatoid arthritis

The paper deconstructs RA synovium using single-cell data to identify six cell type abundance phenotypes associated with distinct inflammatory states.

Collagen-binding integrin alpha11beta1 contributes to joint destruction in arthritic hTNFtg mice

This study shows that integrin alpha11beta1 promotes joint destruction in arthritic mice, and its deficiency reduces disease severity.

Harnessing gene-gene interactions via an RNA-Sequencing network analysis framework improves precision medicine prediction in rheumatoid arthritis

This study uses gene-gene interaction networks from RNA-Seq data to improve prediction of treatment response in rheumatoid arthritis.

Seven chain adaptive immune receptor repertoire analysis in rheumatoid arthritis: association to disease and clinically relevant phenotypes

This study analyzes the seven-chain adaptive immune receptor repertoire in rheumatoid arthritis, identifying disease associations and treatment response markers through immunosequencing and HLA integration.

A Computational Modeling Framework to Analyze Synovial-Tissue Based Drug Targets and Diagnostic Biomarkers in Rheumatoid Arthritis

This study uses computational modeling to identify potential drug targets and diagnostic biomarkers in rheumatoid arthritis by analyzing gene network interactions and pathway perturbations.