Rheumatoid Arthritis Research and Therapies

CD5L insufficiency exacerbates skeletal joint damage in rheumatoid arthritis

This study shows CD5L deficiency worsens joint damage in RA by promoting inflammation and non-classical monocyte expansion.

Fibroblasts neurotrophin signaling sustains pathological vascular maturation in rheumatoid arthritis.

The paper identifies fibroblast-derived neurotrophin signaling as a driver of abnormal vascular maturation in RA synovia and shows that neurotrophin inhibitors can reverse this process.

Autoantigen-specific CD8+ T-cell signature in Rheumatoid Arthritis

This study identifies HLA class I-restricted CD8+ T-cell epitopes in RA and shows how citrullination affects antigen recognition and T-cell clonotype stability.

Silica-mediated exacerbation of inflammatory arthritis: A novel murine model

This paper develops a novel murine model of silica-induced inflammatory arthritis by exposing arthritis-prone mice to crystalline silica, showing it induces arthritis and autoimmunity while DR4-Tg mice are resistant.

TREM2 agonist antibody rebuilds the resident synovial macrophage lining barrier in rheumatoid arthritis

This study shows that a TREM2 agonist antibody rebuilds the synovial macrophage lining barrier in RA by shifting macrophage states toward a barrier-like phenotype.

Investigating the impact of obesity as an immunological instigator on young-onset arthritis using perturbation-based simulation

This paper uses perturbation-based simulation to estimate the impact of childhood obesity on young-onset arthritis prevalence, finding that reducing BMI could prevent 3-5% of cases.

Evidence of an Allostatic Response by Intestinal Tissues Following Induction of Joint Inflammation

The paper investigates how intestinal tissues respond to joint inflammation in a rat model, finding region-specific transcriptomic and microbiome changes.

Spatial patterning of fibroblast TGFβ signaling underlies treatment resistance in rheumatoid arthritis

Perivascular COMPhi fibrogenic fibroblasts expand in treatment-refractory rheumatoid arthritis synovium, where endothelial Notch signaling patterns fibroblast TGF-beta sensitivity via TGFBR3 regulation and persists despite post-treatment immune cell depletion.

Synovial lining expressed mechanosensor PIEZO1 drives inflammation-permissive macrophage phenotypes and joint inflammation

This study identifies PIEZO1 as a mechanosensor driving inflammation-permissive macrophage phenotypes in synovial tissue, contributing to joint inflammation in RA.

Fibroblasts sense spatial proximity via an EGFR CREB5 axis to restore quiescent synovial lining in remission rheumatoid arthritis

The paper identifies a spatial proximity-sensing mechanism in fibroblasts that restores quiescent synovial lining during RA remission through the EGFR-CREB5 axis.

Sexual dimorphism in zymosan-induced arthritis is linked with a higher IFN response in myeloid cell subsets that faithfully recapitulate RA synovial cell clusters

Disease-specific fibroblast-myeloid interactions in rheumatoid arthritis synovium

This study identifies disease-specific fibroblast-myeloid interactions in RA synovium, showing SPP1 signaling and fibroblast-myeloid-dendritic interactions drive RA inflammation by linking innate immunity to autoimmunity.

Exploratory Multi-Omics Profiling of Rheumatoid Arthritis Heterogeneity

This study identifies molecular subtypes and metabolic network changes in RA using multi-omics profiling, suggesting new therapeutic avenues.

Spatial transcriptomics reveals distinct inflammatory and adaptive immune properties of rheumatoid arthritis synovial fibroblasts

This study uses spatial transcriptomics to identify distinct gene expression patterns in RA synovial fibroblasts and macrophages, revealing region- and cell-type-specific roles in inflammation and adaptive immunity.

Discrete cytokine signaling networks instruct distinctsynovial pathotypes in inflammatory arthritis

The paper identifies distinct cytokine signaling networks in mouse models of arthritis that mirror human RA synovial pathotypes, revealing molecular mechanisms underlying disease heterogeneity.

The ontogeny of myeloid-stromal synovial tissue niches in rheumatoid arthritis.

This study shows human synovial tissue-resident macrophages develop from monocytes guided by fibroblast-derived cues in specific spatial niches, using a novel organoid system.

Senescent Activated Naive B Cells Promote Anti-Citrullinated Antigen T Cell Responses and the Transition to Clinical Rheumatoid Arthritis

This study identifies senescent activated naive B cells in ACPA+ individuals that promote anti-citrullinated antigen T cell responses and drive progression to clinical RA.

Systemic inflammation and lymphocyte activation precede rheumatoid arthritis

The paper identifies immune alterations preceding rheumatoid arthritis onset and provides tools for dataset exploration.

Immune Responses Targeting Homocitrullinated Peptides Drive Rheumatoid Arthritis-like Pathology in HLA-DR4 Transgenic Mice

This study shows that homocitrulline-specific immune responses induce RA-like pathology in HLA-DR4 transgenic mice, supporting the pathogenic role of anti-homocitrullinated protein autoantibodies in RA.

Identification of a novel transcriptome signature for predicting the response to anti-TNF-α treatment in rheumatoid arthritis patients

The paper identifies a seven-gene transcriptomic signature that predicts response to anti-TNF-α treatment in rheumatoid arthritis patients with high accuracy.

Immunological and Biochemical Profiles in Rheumatoid Arthritis: Sex-Dependent Variations and Organ Function Implications

This study examines immunological and biochemical differences in rheumatoid arthritis patients compared to healthy controls, revealing sex-specific variations in inflammatory markers and organ function.

Dual inhibition of glutaminolysis and autophagy suppresses proliferation of Rheumatoid arthritis fibroblast-like synoviocytes and mitigates arthritis in SKG mice

This study shows that inhibiting both glutaminolysis and autophagy reduces RA-FLS proliferation and arthritis in SKG mice.

JAK Inhibitor Withdrawal Causes a Transient Proinflammatory Cascade: A Potential Mechanism for Major Adverse Cardiac Events

This study shows that stopping Type I JAK inhibitors leads to a temporary pro-inflammatory response, which may explain some cardiac issues linked to JAK inhibitor use.

Cellular composition of tissue-resident monocyte-lineage cells reveal functional heterogeneity during inflammatory arthritis

The paper identifies three subpopulations of tissue-resident monocyte-lineage cells in inflammatory arthritis and examines their origins and responses to synovial disruption.

Mitochondrial calcium uniporter regulates human fibroblast-like synoviocytes invasion via altering mitochondrial dynamics and dictates rheumatoid arthritis pathogenesis

This study shows that inhibiting the mitochondrial calcium uniporter reduces fibroblast-like synoviocytes migration and mitochondrial dysfunction in rheumatoid arthritis.

Insulin exerts epigenetic control of joint-specific memory T cells in rheumatoid arthritis

This study shows insulin influences epigenetic regulation of memory T cells in RA via H3K27ac-survivin mechanism, affecting metabolic activity and immune responses.

Cochlin-Expressing Memory B (COMB) Cells Are Enriched in Autoimmune Diseases and Display a Distinct Activation Profile

The paper identifies a novel memory B cell subset, COMB cells, enriched in autoimmune diseases and characterized by distinct transcriptional and epigenetic features.

Anti-citrullinated protein antibodies arise during affinity maturation of germline antibodies to carbamylated proteins in rheumatoid arthritis

This study shows that anti-citrullinated protein antibodies (ACPAs) in RA arise from germline antibodies targeting carbamylated proteins through affinity maturation and somatic hypermutations.

Deep immunophenotyping reveals circulating activated lymphocytes in individuals at risk for rheumatoid arthritis

The paper identifies activated lymphocyte phenotypes in individuals at risk for rheumatoid arthritis using mass cytometry and develops an immunophenotype score to distinguish these individuals from controls.

Comprehensive analysis of myeloid reporter mice

This study presents lineage tracing results from 18 myeloid-specific fate-mapping models in mouse peripheral blood and synovial tissue, validating synovial macrophage identification through flow cytometry and CITE-seq.