Nerve injury and regeneration

KHSRP-mediated Decay of Axonally Localized Prenyl-Cdc42 mRNA Slows Nerve Regeneration

The paper shows that KHSRP-mediated decay of axonal Prenyl-Cdc42 mRNA slows nerve regeneration by regulating mRNA stability and transport in response to growth signals.

A tribenzamide small molecule with retinoic acid-like activity promotes axon growth and motor recovery after spinal cord injury.

This paper identifies a small molecule DM04 that mimics retinoic acid's effects on axon growth and motor recovery after spinal cord injury, acting through a non-canonical mechanism.

Axonal injury signaling is restrained by a spared synaptic branch

The paper shows that Wnd/DLK signaling in Drosophila motoneurons is activated only when synaptic terminals are completely removed, not when they are partially spared.

Acetylation of Axonal G3BP1 through ELP3 Accelerates Axon Regeneration

This study shows that acetylation of G3BP1 by ELP3 promotes axon regeneration and neuronal recovery after injury.

CASPR facilitates clearance of degenerating axons by Schwann cells and macrophages after peripheral nerve injury

This study identifies CASPR as a novel 'eat-me' signal promoting axonal debris clearance by Schwann cells and macrophages after peripheral nerve injury.

A human iPSC-derived motor neuron-myogenic cell coculture platform to evaluate neuromuscular junction innervation after axon injury and in Spinal Muscular Atrophy

This paper develops a human iPSC-derived motor neuron-myogenic coculture platform to study NMJ innervation after axon injury and in SMA, showing blebbistatin enhances NMJ reinnervation and confirming reduced NMJ function in SMA patient-derived neurons.

Axonal mTOR-dependent Rab5 translation drives axonal transport and BDNF signaling to the nucleus

The paper shows that axonal mTOR-dependent Rab5 translation is essential for BDNF signaling and retrograde transport to the nucleus.

Optic nerve regeneration requires the intracellular domain of LIFRa/CD118

This study identifies the intracellular domain of LIFR/CD118 as essential for optic nerve regeneration in mature RGCs, independent of LIF and other therapies.

Axon Regeneration and Functional Recovery after Spinal Cord Injury is Enhanced by Allele-Specific ApoE Neuronal Action through LRP8

This study shows that ApoE2 overexpression via AAV improves axon regeneration and motor function after spinal cord injury through LRP8 signaling without affecting inflammation or scarring.

Sarm1 is not necessary for activation of neuron-intrinsic growth programs yet required for the Schwann cell repair response and peripheral nerve regeneration.

Golgi compaction facilitates microtubule nucleation to drive adult vertebrate peripheral neuron regeneration

This study identifies Golgi compaction as a key driver of peripheral neuron regeneration by facilitating microtubule nucleation through AKAP9 and γ-tubulin recruitment, showing conservation in rat and human models.

Impaired axon regeneration and heightened synaptic dynamics in the injured aged mammalian cortex

This study investigates age-related changes in axon regeneration and synaptic dynamics in the injured aged mammalian cortex, finding impaired regeneration and increased synaptic reorganization.

Mena-dependent local translation of PI3K-p85 coordinates the axonal regenerative program upon injury

This study identifies Mena as a regulator of local protein synthesis in adult axons, showing it controls PI3K-p85 mRNA translation and axon regeneration after injury.

A dNmnat-sensitized in vivo platform for unbiased discovery of regulators of neurodegeneration

This paper develops a genetic screening platform in Drosophila to identify regulators of axon degeneration by depleting dNmnat, revealing new factors that influence neuronal survival and NAD+ homeostasis.

Sensory neurons shape macrophage identity via TGF-β signalling

This study identifies TGF-β as a key mediator of macrophage specialization in the skin through interaction with sensory nerves.

Retrograde transport of neurotrophin receptor TrkB-FL induced by excitotoxicity regulates Golgi stability and is a target for stroke neuroprotection

The paper demonstrates that excitotoxicity-induced TrkB-FL downregulation is due to retrograde transport to the Golgi and shows that a neuroprotective peptide can interfere with this process to preserve Golgi stability and neuronal survival in stroke.

3D Printed Nerve Guidance Conduit for Biologics-Free Nerve Regeneration and Vascular Integration

This paper develops a biologics-free 3D-printed nerve guidance conduit that restores motor function comparable to autografts in a mouse model.

Human nasal olfactory stem cell-derived extracellular vesicles improve the repair of rat nerves

This study shows that human nasal olfactory stem cell-derived extracellular vesicles improve nerve repair in rats by enhancing locomotor recovery, muscle function, and axon regeneration.

A Drosophila Tonic Motor Neuron Reinnervates Ectopic Muscles Fully Deprived of Native Tonic and Phasic Inputs

This study shows that Drosophila tonic motor neurons can reinnervate denervated muscles through structural plasticity, while phasic neurons show minimal remodeling.

Complexes between Netrin G Ligands and Chiral Nanoparticles Promote Axons Regeneration under Near-Infrared Illumination

This study shows that glutathione-coated Ni(OH)2 nanoparticles form complexes with NGL-1, promoting axon regeneration in Alzheimer's and spinal cord-injured mice under near-infrared light.

Schwann cells modified to secrete MANF is a potential cellular therapy for peripheral nerve regeneration

This study shows that modifying Schwann cells to secrete MANF improves peripheral nerve regeneration in rats.

Inhibiting Clarinet/CLA-1 restores function to injured motor neurons

This study shows that inhibiting Clarinet/CLA-1 in C. elegans enhances axon regeneration without affecting synapse reformation, suggesting a potential therapeutic target for nerve repair.

Erythropoietin decreases apoptosis and promotes Schwann cell repair and phagocytosis following nerve crush injury in mice

This study shows EPO reduces apoptosis and enhances Schwann cell repair and phagocytosis in mice with nerve crush injury, improving functional recovery.

Inferior Reinnervation of Reverse End-to-Side Nerve Transfer in a Delayed Nerve Repair Rat Model

This study evaluates RETS nerve transfer in a delayed rat nerve injury model, finding inferior donor nerve regeneration but successful NMJ formation, and highlights the role of regeneration tracks in repair outcomes.

Buyang Huanwu Decoction Ameliorates Peripheral Nerve Injury by Promoting Cell Cycle through Activation of PI3K/AKT/mTOR/HIF-1α Pathway

AxoMetric: A Rapid and Unbiased Tool for Automated Quantification of Axon Regeneration in Tissue Sections

AxoMetric quantifies axon regeneration in tissue sections with speed and accuracy, matching manual methods while enabling high-throughput analysis.

Etv5 is not required for Schwann cell development but is required to regulate the Schwann cell response to peripheral nerve injury

This study shows Etv5 is not needed for Schwann cell development but is essential for regulating their response to peripheral nerve injury.

Optogenetic activation of entorhinal projection neurons alters the target recognition and circuit development without enhancing axon regeneration after axotomy in organotypic slices.

This study uses organotypic slice cultures to show that optogenetic activation of entorhinal neurons does not enhance axon regeneration after injury but alters target recognition and circuit development.

Nuclear Receptor Transcription factors promote axon regeneration in the Adult Corticospinal Tract

This study identifies NR2F1 and NR2F6 as nuclear receptor transcription factors that promote axon regeneration in the corticospinal tract through chromatin remodeling, enhancer redeployment, and translational reprogramming.

Serotonin neuromodulation directs optic nerve regeneration

The paper identifies serotonin type-1 receptor signaling as a key regulator of early optic nerve regeneration in zebrafish, showing it promotes axonal regrowth but is dispensable during development.