Retinal Development and Disorders

Smarcc1 is essential for the patterning of the optic stalk and differentiation of the optic nerve head astrocytes

This study identifies Smarcc1's role in optic stalk development and optic nerve head astrocyte differentiation, showing its necessity for morphogenesis and RGC survival.

BDH1-Dependent Ketone Body Metabolism Maintains Muller Cell Homeostasis and Retinal Function

This study shows that BDH1-dependent ketone metabolism supports Muller cell function and retinal health, with implications for treating retinal diseases.

Targeted delivery of rhodopsin's assembled core is required for outer segment extension in mouse rod photoreceptors

This study identifies the minimal requirements for rhodopsin's targeted delivery to drive outer segment extension in mouse rod photoreceptors.

Restoration of Higher-Order Cortical Processing in Rat V2 by Retinal Sheet Transplants in Degenerated Rats

This study shows that retinal sheet transplants restore higher-order visual processing in rat V2 by recovering surround suppression, a key mechanism for visual perception.

Female sex is a risk factor for exacerbated lipid peroxidation and disease in murine retinitis pigmentosa

This study shows female sex accelerates retinal degeneration in mouse models of retinitis pigmentosa, linked to increased lipid peroxidation after sexual maturity.

Afadin-deficient mouse retinas exhibit severe neuronal lamination defects but preserve visual functions

This study shows that afadin deficiency in mice causes severe retinal lamination defects but preserves some visual function through retained local field potentials and RGC classification.

Dopaminergic Control of Retinal Oscillations Driving Infantile Nystagmus

This paper identifies dopaminergic modulation of AII amacrine cells as a therapeutic target for infantile nystagmus by showing that restoring dopamine suppresses retinal oscillations and improves visual signal fidelity.

Gelatinase activity is required for Muller glia morphogenesis and neuronal maintenance in the retina

This study shows that Mmp2 and Mmp9 are essential for Muller glia morphogenesis and neuronal maintenance in the zebrafish retina.

Taking it slow: A positive feedback chloride current in cone photoreceptors supports slow motion detection

This study identifies a positive feedback chloride current in cone photoreceptors that enhances slow motion detection by sustaining photovoltage responses and counteracting adaptation.

Pre-clinical validation of a novel AAV-mediated gene therapy for KCNV2 retinopathy improves visual function in a mouse model and expression in patient organoids

This paper demonstrates that AAV-mediated gene therapy restores retinal function and KCNV2 expression in a mouse model of KCNV2 retinopathy and human retinal organoids.

The retinal light response is modulated by an mGluR5-mediated retrograde signal from ON-bipolar cells to photoreceptors

This paper shows that mGluR5 in ON-bipolar cells modulates light response via endocannabinoid retrograde signaling, affecting ERG b-wave amplitude and intensity-response curves.

A Congenic C57BL/6 rd1 Mouse Model for Retinal Degeneration Research

The paper describes the development of a congenic C57BL/6 rd1 mouse model to improve retinal degeneration research by reducing genetic variability.

Ptbp1 is not required for retinal neurogenesis and cell fate specification.

This study shows Ptbp1 is not required for retinal neurogenesis or cell fate specification, contradicting prior claims of its role as a master regulator.

Electroporation-Based Gene Delivery and Whole-Organoid Imaging in Human Retinal Organoids

This paper introduces an electroporation-based method for efficient gene delivery in human retinal organoids, combined with two-photon microscopy for high-resolution imaging.

The long noncoding RNA Peanut (Gm11454) promotes neurogenesis and rod photoreceptor differentiation during postnatal retinal development.

This study identifies the lncRNA Peanut as promoting rod photoreceptor differentiation and neurogenesis by inhibiting Notch signaling and regulating Tox2 expression in retinal progenitor cells.

Overexpression of Meis factors in late-stage retinal progenitors yields complex effects on temporal patterning and neurogenesis.

This study shows that overexpressing Meis1 and Meis2 in postnatal mouse retinal progenitor cells has distinct effects on temporal identity and neurogenesis, without fully reprogramming cell fate.

D1R- and D4R-Dependent Regulation of Retinal Light Adaptation in Diabetes

This study examines how blocking D4R and D1R receptors affects ERG signaling in diabetic rodents, finding that D4R blockade significantly alters light adaptation in diabetic retinas.

Visualization of photoreceptor outer segment renewal using AAV-delivered Dendra2-tagged rhodopsin

This study uses AAV-delivered Dendra2-tagged rhodopsin to track photoreceptor outer segment renewal in mice, showing reduced renewal in a ciliopathy mutant.

AAV-mediated regeneration of neurons in injury-induced and inherited retinal degeneration

This study shows that AAV-delivered Neurog2-9SA converts Muller glia into retinal neurons in degenerative models, integrating into circuits and exhibiting neuronal properties.

Imaging Electrical Activity of Retinal Ganglion Cells with Fluores-cent Voltage and Calcium Indicator Proteins in Retinal Degenera-tive rd1 Blind Mice

The paper uses fluorescent voltage and calcium indicators to image electrical activity in retinal ganglion cells of rd1 mice, showing cellular precision and millisecond resolution.

Production of clinical grade patient iPSC-derived 3D retinal organoids containing transplantable photoreceptor cells

This study develops a xeno-free 3D retinal differentiation protocol for iPSCs to generate transplantable photoreceptor cells in a cGMP-compliant manner.

Fixel-Based Analysis reveals microstructural visual pathway changes associated with retinal remodeling in retinitis pigmentosa

This study uses multimodal imaging to show microstructural changes in visual pathways associated with retinal remodeling in retinitis pigmentosa.

Inherited retinal degenerations: PARP regulates calpain activation via TRPM2 channels in rd1 mouse photoreceptors

This study investigates how PARP regulates calpain activity in rd1 mouse photoreceptors and identifies potential therapeutic targets for inherited retinal degenerations.

Retinal organoids mirror CRISPR/Cas9 gene editing efficiency observed in vivo

The paper compares CRISPR/Cas9 gene editing efficiency in retinal organoids, HEK293T cells, and mouse models, finding retinal organoids better mirror in vivo editing outcomes.

Biophysical Basis of the in vivo ERG of the Mouse: Rod, RPE and Müller glial Cell Contributions To Dark and to Light-driven Changes in Sub-Retinal Space o

The paper measures ERGs in mice to assess contributions of rod, RPE, and Müller glial cells to dark and light-driven changes in sub-retinal space ion concentrations.

Preservation of vision after chemically induced retinal ganglion-like-cell transplantation.

This study generates human retinal ganglion-like cells (CiRGCs) from fibroblasts using small molecules and shows their functional preservation after transplantation in retinal injury models.

Sox9 prevents retinal degeneration and is required for limbal stem cell differentiation in the adult mouse eye

This study shows that Sox9 is essential for maintaining retinal integrity and limbal stem cell differentiation in adult mice through genetic ablation and single-cell RNA sequencing.

Mini-Pcdh15b Gene Therapy Rescues Visual Deficits in a Zebrafish Model of Usher Syndrome Type 1F

This paper shows that a gene therapy using a shortened PCDH15 variant rescues vision in a zebrafish model of Usher Syndrome Type 1F.

Characterization of Postsynaptic Glutamate Transporter Functionality in the Zebrafish Retinal First Synapse Across Different Wavelengths

The paper shows that EAAT5b and EAAT7 have wavelength-specific roles in zebrafish retinal function, affecting responses to short and long-wavelength stimuli but not middle-wavelengths.

Evolutionary remodeling of the ventral retina enables aerial vision in the four-eyed fish Anableps anableps

This study identifies how the four-eyed fish Anableps anableps evolved dual aerial and aquatic vision through developmental and functional remodeling of its ventral retina.