Extracellular vesicles in disease

Serum exosome miR-150-5p in rheumatic heart disease-associated angiogenesis

This study investigates how exosomes from RHD patients promote angiogenesis by upregulating miR-150-5p, which reduces TP53 expression in endothelial cells.

Engineering liposomes with cell membrane proteins to disrupt melanosome transfer

This paper engineers liposomes with cell membrane proteins to disrupt melanosome transfer from melanocytes to keratinocytes, offering a drug-free strategy for treating hyperpigmentation.

Th2 cell extracellular vesicles promote eosinophil survival through the cytokine cargo IL-3 and prolong airway eosinophilia.

This study shows Th2 cell extracellular vesicles carry IL-3, which promotes eosinophil survival and prolongs airway eosinophilia during allergic inflammation.

Bacterial extracellular vesicles as a tunable platform for vaginal drug delivery

This study evaluates bacterial extracellular vesicles as a tunable platform for vaginal drug delivery, showing effective protein loading and retention in the murine reproductive tract without adverse effects.

Uncovering the bequeathing potential of Apoptotic Mesenchymal Stem Cells via small Extracellular Vesicles for its enhanced immunomodulatory ability

This study compares the immunomodulatory and antioxidant effects of apoptotic and viable sEVs from bone marrow and Wharton's jelly MSCs in an in vitro liver injury model.

Extracellular Vesicles heterogeneity through the lens of multiomics

This study provides a multiomics resource of cancer extracellular vesicles, showing correlations between LO proteins and prostate cancer progression, and demonstrating the feasibility of single-cell RNA-Seq on EVs.

Extracellular vesicle-derived miR-425-5p (miR-425) activates astrocytes in the brain to promote breast cancer brain metastasis via the novel miR-425-ZNF24-CCL8 signaling axis

This study identifies miR-425 in breast cancer extracellular vesicles as a driver of brain metastasis by activating astrocytes through the miR-425-ZNF24-CCL8 signaling axis.

Temporal changes in the protein cargo of extracellular vesicles and resultant immune reprogramming after severe burn injury in humans and mice.

This study examines temporal changes in extracellular vesicle (EV) protein cargo in burn-injury patients and mice, showing distinct immune reprogramming effects at early and late post-injury stages.

Proteomic and Metabolomic Profiling of Archaeal Extracellular Vesicles from the Human Gut

This study profiles proteomic and metabolomic features of archaeal extracellular vesicles from the human gut, revealing their structural similarity to bacterial EVs and their potential to modulate immune responses.

Biogenesis of DNA-carrying extracellular vesicles by the dominant human gut methanogenic archaeon

This study characterizes DNA-carrying extracellular vesicles (EVs) from Methanobrevibacter smithii, revealing their role in DNA and protein export in the gut.

Small Extracellular Vesicles from Human Bone Marrow Mesenchymal Stromal Cells enhance migration and regulate gene expression of reparative mechanisms in human dermal fibroblasts

This study compares the effects of sEV and NsEV fractions from hBM-MSCs and NHDFs on fibroblast migration and gene expression, finding sEVs more effective in promoting migration.

Extracellular Vesicles from Multiple Sclerosis White Matter Exhibit Synaptic, Mitochondrial, Complement, and Aging-related Pathway Dysregulation

The paper analyzes extracellular vesicles from MS and control white matter to identify pathway dysregulation and cellular origin shifts associated with the disease.

The microRNA regulatory landscape of skeletal muscle-derived extracellular vesicles

This study characterizes the miRNA composition of skeletal muscle-derived extracellular vesicles and identifies their involvement in key biological pathways and potential therapeutic roles.

Structure and organization of full-length Epidermal Growth Factor Receptor in extracellular vesicles by cryo-electron tomography

The paper uses cryo-electron tomography to study the structure of full-length EGFR in extracellular vesicles, revealing its clustering and signaling domain positioning.

Extracellular Exosomal RNAs are Glyco-Modified

This study identifies glyco-modified RNAs in exosomes, showing their role in intercellular communication and suggesting a link between protein and RNA glycosylation.

Extracellular vesicles from diverse fungal pathogens induce species-specific and endocytosis-dependent immunomodulation

This study shows that fungal extracellular vesicles induce species-specific immunomodulation in macrophages through endocytosis-dependent mechanisms, with varying cytokine responses and immune signaling.

Small Extracellular Vesicles by Nucleus Pulposus Cells Maintain Niche and Cell Homeostasis via Receptor Shuffling and Metabolic Enzyme Supplements

The paper investigates the proteome of nucleus pulposus cell-derived small extracellular vesicles and identifies mechanisms by which they maintain niche homeostasis through receptor trafficking and metabolic enzyme delivery.

Multiomics unveils extracellular vesicle-driven mechanisms of endothelial communication in human carotid atherosclerosis

This study identifies EV-driven endothelial communication in human carotid atherosclerosis, showing increased angiogenic activity in symptomatic plaques.

miR-196a-5p and miR-342-3p mediate skeletal muscle and thermogenic adipose tissue crosstalk through extracellular vesicles

This study identifies miR-196a-5p and miR-342-3p as exomiRs released during exercise that mediate crosstalk between skeletal muscle and thermogenic adipose tissue.

Aptamer-Enabled Discovery and Clinical Analysis of Exosomal Surface Biomarkers in Hepatocellular Carcinoma

The paper develops an aptamer-based platform for discovering and analyzing exosomal surface biomarkers in hepatocellular carcinoma, achieving high accuracy in clinical validation.

Let-7b-5p loaded Mesenchymal Stromal Cell Extracellular Vesicles reduce Pseudomonas- biofilm formation and inflammation in CF Bronchial Epithelial Cells

This paper shows that let-7b-5p-loaded MSC EVs block antibiotic-resistant P. aeruginosa biofilm formation and reduce inflammation in CF bronchial epithelial cells.

Scalable, high-throughput isolation of extracellular vesicles using electrokinetic-assisted mesh filtration

This paper introduces ExoFilter, an electrokinetic-assisted mesh filtration system for scalable and high-throughput extracellular vesicle isolation with high recovery efficiency.

Efficient delivery of small RNAs to podocytes in vitro by direct exosome transfection.

This study demonstrates that directly transfected exosomes can deliver small RNAs to podocytes in vitro, showing efficient cargo uptake and functional effects.

Preferential Release of microRNAs via Extracellular Vesicles is Associated with Ductal Carcinoma In Situ to Invasive Breast Cancer Progression

This study shows that sEVs and their miRNAs, particularly miR-205, promote DCIS progression and that inhibiting sEV release or re-expressing miR-205 can reduce invasive properties in DCIS cells.

HO-3867 mediated modulation of Extracellular vesicles and Tumor microenvironment: A novel immunotherapeutic strategy for ovarian cancer

This study shows that HO-3867 and bevacizumab together reduce ascites, limit tumor spread, and enhance anti-tumor immunity in ovarian cancer models by modulating extracellular vesicles and immune cells.

Differential effects of ischemia and inflammation on plasma-derived extracellular vesicle characteristics and function

This study examines how ischemia and inflammation affect plasma-derived extracellular vesicle characteristics and function in brain tissue, finding that both types of EVs induce pro-inflammatory cytokine expression without distinct glial reactivity.

The biomolecular profiles of extracellular vesicles from odontogenic stem cell lines depict donor-dependent differences and emphasize their therapeutic and regenerative potential

This study compares extracellular vesicles from three odontogenic cell types, finding donor-specific differences and highlighting their therapeutic potential.

Development of a liquid biopsy for bladder cancer using a mutant protein panel in urinary extracellular vesicles

The paper identifies mutant proteins in urinary extracellular vesicles using a proteogenomics pipeline and shows their correlation with bladder cancer tumor burden, suggesting a non-invasive liquid biopsy method.

Ex Vivo Removal of CD41 positive platelet microparticles from Plasma by a Medical Device containing a Galanthus nivalis agglutinin (GNA) affinity resin

This study demonstrates that the Hemopurifier device removes 98.5% of platelet microparticles from healthy human plasma in a 4-hour session.

Metabolic adaptations of micrometastases alter EV production to generate invasive microenvironments

The paper shows that breast cancer micrometastases alter metabolism to change extracellular vesicle production, creating an invasive microenvironment.