Renin-Angiotensin System Studies

Association of ACE I/D Polymorphism with Essential Hypertension in South-Asian Populations, Gender-Bias in Indian Populations: Evidence from Case-Control and Meta-Analysis Studies

The paper investigates the association of ACE I/D polymorphism with essential hypertension in South-Asian populations, finding a significant risk allele and gender bias in Indian populations.

Chronic Treatment of a Mouse Model of Cerebral Amyloid Angiopathy and Brain AT1 Receptor Expression

The study examines AT1 receptor levels in a mouse model of cerebral amyloid angiopathy and evaluates the effects of RAAS-targeting drugs, finding no significant changes but noting trends.

Bright Cells, and Inefficient Enzymatic Activity in a Renin Hypomorph Mouse

This paper describes a mouse model with a bright fluorescent reporter for renin-expressing cells, revealing renin hypomorphism and associated kidney dysfunction under RAS inhibition.

Strain Matters: The 129S1/SvlmJ Mouse Model Reveals the Genetic and Inflammatory Susceptibility to Hypertensive Complications

This study compares two mouse strains to show that genetic background affects susceptibility to hypertensive complications, with 129S1/SvlmJ mice showing more severe organ damage and inflammation.

Vasoinhibin is Generated by the Renin-Angiotensin System

This study identifies renin as a protease that cleaves prolactin to generate vasoinhibin, a RAS-mediated regulator of blood vessel growth and function.

Microbial metabolite 4-ethylphenylsulfate (4EPS) interacts with AT1R, reduces blood pressure and outcome of AngII-induced aortic aneurysm

This study shows that 4-ethylphenylsulfate (4EPS) interacts with AT1R, lowers blood pressure, and reduces aortic aneurysm severity in mice.

Smooth Muscle Cells and Fibroblasts in the Proximal Thoracic Aorta Exhibit Minor Differences Between Embryonic Origins in Angiotensin II-driven Transcriptional Alterations

The paper examines transcriptomic changes in smooth muscle cells and fibroblasts from different embryonic origins in the proximal thoracic aorta under AngII infusion, finding modest differences between origins.

Mathematical Modeling of Impacts of Patient Differences on Renin-Angiotensin System and Applications to COVID-19 Lung Fibrosis Outcomes

This paper develops a multiscale computational model to study how patient-specific factors affect the renin-angiotensin system and its role in COVID-19 lung fibrosis outcomes.

Coagulation factor XII contributes to renin activation, heart failure progression, and mortality

The paper identifies coagulation factor XII as a driver of renin activation, contributing to heart failure progression and mortality.

Angiotensin Converting Enzyme Hub Model of Peptide Flux Relating Calculated AT1 Receptor and Aldosterone Levels

The paper develops a hub model of peptide flux in the RAAS system using VICTAS Trial data to relate AT1 receptor and aldosterone levels.

Convergence of Angiotensin Signaling on Lung Pericyte and Stromal Behaviors

The paper identifies AGTR1 as a selective marker for lung pericytes and shows its role in regulating pericyte behaviors in the airspace microvasculature.

Oxidized low-density lipoprotein potentiates angiotensin II-induced Gq activation through the AT1-LOX1 receptor complex: Implications for renal dysfunction

This study shows oxLDL enhances Ang II-induced Gq signaling via the AT1-LOX1 complex, contributing to renal dysfunction in CKD and hypertension.

Mathematical modeling of the influence of ACE I/D polymorphism on blood pressure and antihypertensive therapy

This study uses a computational model to examine how the ACE I/D polymorphism affects blood pressure and antihypertensive therapy efficacy, finding limited predictive value of the variant.

ACE1 knockout in neurons selectively dysregulates the hippocampal renin angiotensin system and causes vascular loss

This study shows that neuronal ACE1 knockout in mice causes hippocampal RAS dysregulation and vascular loss without affecting motor skills.

Analysis of the Combined Effect of rs699 and rs5051 on Angiotensinogen Expression and Hypertension

This study investigates the combined effect of rs699 and rs5051 on angiotensinogen expression and hypertension, finding no significant difference in liver AGT expression or hypertension phenotypes when the variants occur independently.

Epigenetic and transcriptional regulation of the human angiotensinogen gene by high salt

This study investigates how high salt affects DNA methylation and transcriptional regulation of the angiotensinogen gene in liver and kidney, showing increased gene expression and demethylation.

Protein Kinase A Inhibition Epigenetically Silences Ren1

The paper investigates how PKA inhibition affects renin expression by altering epigenetic marks and gene regulation at the renin locus.

Genetic reprogramming by brief inhibition of the renin-angiotensin system in spontaneously hypertensive rats leads to persistently reduced kidney renin and low blood pressure.

The paper shows that early treatment with RAS inhibitors in SHR reduces kidney renin expression and lowers blood pressure long-term through genetic and epigenetic changes.

Functional Exploration of Conserved Sequences in the Distal Face of Angiotensinogen

This study investigates the functional role of conserved sequences in the loop and β-sheet regions of angiotensinogen, showing that mutations in either region individually have no effect, but combined mutations impair AGT secretion.

ERAP1 Shows Distinct Regulatory Mechanisms on Blood Pressure Modulation Between Males and Females

The paper was withdrawn due to an editing error and is not intended for citation.

The central renin angiotensin II system: a genetic pathway, functional decoding and selective target engagement characterization in humans

This study characterizes the brain renin angiotensin II system's architecture and function using imaging transcriptomics and fMRI, showing AT1R's role in cognition and behavior through specific circuits and interactions with neurotransmitter systems.

EVIDENCE FOR ANGIOTENSIN II AS A NATURALLY EXISTING SUPPRESSOR FOR THE NATRIURETIC PEPTIDE SYSTEM

This study provides evidence that angiotensin II suppresses the natriuretic peptide system by inhibiting cGMP production via AT1 receptor and PKC, supporting dual-targeting therapies for cardiovascular disease.

Determinants of renin cell differentiation: a single cell epi-transcriptomics approach

The paper uses single-cell epi-transcriptomics to map the developmental trajectory of renin cell differentiation and identifies key transcription factors involved in their formation.

Repeated ethanol exposure and withdrawal alters ACE2 expression in discrete brain regions: Implications for SARS-CoV-2 infection

The paper examines how chronic ethanol exposure affects ACE2 and TMPRSS2 expression in specific brain regions, suggesting increased vulnerability to SARS-CoV-2 neuroinvasion.

Artificial intelligence-assisted meta-analysis of the frequency of ACE I/D polymorphisms in centenarians and other long-lived individuals.

This paper performs a meta-analysis of ACE I/D polymorphisms in centenarians and long-lived individuals, finding a positive association of the DD genotype with longevity but not the ID genotype.

Late Fetal and Newborn Granulopoiesis but not Active Renin is Increased by Maternal Captopril Treatment During Perinatal Kidney Development

The paper examines the effects of maternal captopril treatment on renin expression and granule formation in fetal and newborn mouse kidneys, finding increased granulation without changes in active renin content.

Angiotensin II Inhibits the A-type K+ Current of Hypothalamic Paraventricular Nucleus Neurons in Rats with Heart Failure: Role of MAPK-ERK1/2 Signaling

This study investigates how angiotensin II modulates the A-type K+ current in PVN neurons via the MAPK-ERK pathway in rats with heart failure.

MiR-339-3p aggravates rat vascular inflammation induced by AT1R autoantibodies by down-regulating BKα protein expression

This study identifies miR-339-3p as a key regulator in AT1-AA-induced vascular inflammation by downregulating BKα protein expression through the miR-339-3p/NEDD4L axis.

Deficiency of MicroRNA-181a Results in Transcriptome-Wide Cell Specific Changes in the Kidney that Lead to Elevated Blood Pressure and Salt Sensitivity

This study shows that miR-181a deficiency in mice leads to elevated blood pressure and salt sensitivity through increased renin expression and widespread renal gene dysregulation.

Renal Angiotensinogen in Nonhuman Primates is Predominantly Liver-Derived

This study shows that renal angiotensinogen in nonhuman primates is mainly derived from the liver, as evidenced by reduced renal AGT levels after liver-specific AGT inhibition.