Nicotinic Acetylcholine Receptors Study

Enhanced prefrontal nicotinic signaling as evidence of active compensation in Alzheimer's disease models

The paper shows enhanced nicotinic signaling in prefrontal cortex of AD models, which can be amplified by nicotinic receptor modulation without altering kinetics.

Mechanism of NACHO-mediated assembly of pentameric ligand-gated ion channels

This paper identifies NACHO as an ER-resident protein that facilitates the assembly of pentameric ligand-gated ion channels by interacting with subunit interfaces.

A heteromeric nicotinic acetylcholine receptor promotes sleep by relaying GABAergic signals within a locus of motor and sensory integration

This study identifies a heteromeric nicotinic acetylcholine receptor in Drosophila that promotes sleep by relaying GABAergic signals in the ventral nerve cord.

Sex-dependant differences in the ability of nicotine to modulate discrimination learning and cognitive flexibility in mice.

This study investigates sex-dependent effects of nicotine on discrimination learning and cognitive flexibility in mice, finding differential impacts on visual discrimination and reversal learning tasks.

Impairment of brain function in a mouse model of Alzheimer's disease during the pre-depositing phase: the role of alpha7 nicotinic acetylcholine receptors

This study shows that in a mouse model of Alzheimer's disease, before amyloid deposition, there are increased inflammatory markers, reduced nicotinic acetylcholine receptors, and impaired memory, which can be mitigated by targeting alpha7 nAChRs.

A conserved RNA switch for acetylcholine receptor clustering at neuromuscular junctions in chordates

The paper shows that the RNA switch for acetylcholine receptor clustering is conserved in Ciona robusta, with some structural differences in Nova and regulation by Ebf.

The Role of Glucocorticoid and Nicotinic Acetylcholine Receptors in the Reward-Enhancing Effects of Nicotine in the ICSS Procedure in Male and Female Rats

This study investigates how nicotine's rewarding effects in rats are influenced by glucocorticoid and nicotinic acetylcholine receptors using the ICSS procedure.

A unique multi-synaptic mechanism regulates dopamine release in the nucleus accumbens during adolescence

The paper investigates differences in dopamine release regulation in adolescent versus adult rats, identifying a unique multisynaptic mechanism involving acetylcholine and nicotinic receptors.

CHRFAM7A overexpression in human iPSC-derived Interneurons dysregulates α7-nAChR surface expression and alters response to oligomeric β-amyloid peptide

This study shows that overexpression of CHRFAM7A in human iPSC-derived interneurons reduces surface α7-nAChR and alters ROS response to Aβ1-42.

SH3BP2 regulates the organization of the neuromuscular synapses through protein-driven phase separation

This study identifies SH3BP2 as a regulator of neuromuscular synapse organization by promoting AChR clustering through phase separation, and shows its deletion causes synaptic defects in mice.

Identification of the potential function-specific sites in subunits of vertebrate neuronal nicotinic acetylcholine receptors

This study identifies function-specific sites in nAChR subunits using evolutionary analysis and spatial modeling, showing their roles in ligand binding and conformational changes.

Impacts of Perinatal Nicotine Exposure on nAChR Expression and Glutamatergic Synaptic Transmission in the Mouse Auditory Brainstem

This study examines how nicotine exposure during pregnancy affects nAChR expression and glutamatergic transmission in the mouse auditory brainstem, revealing synaptic impairments linked to auditory processing deficits.

Subunit positioning and diversity of the nematode levamisole-sensitive acetylcholine receptor

This study identifies the subunit stoichiometry and arrangement of the C. elegans L-AChR and shows functional divergence between ACR-8 and ACR-13.

α7 nicotinic acetylcholine receptors are necessary for basal forebrain activation to increase expression of the nerve growth factor receptor TrkA

The paper shows that α7 nicotinic acetylcholine receptors are required for basal forebrain activation to increase TrkA expression, but not for BACE1 decreases in 5xFAD mice.

Nicotinic acetylcholine receptor signaling maintains epithelial barrier integrity

The paper identifies COPD risk genes using Drosophila melanogaster, validating their role in epithelial barrier function through nAchR signaling in the gut.

Identification of a binding site for bupropion in Gloeobacter violaceus ligand-gated ion channel

This study identifies a binding site for bupropion in the Gloeobacter violaceus ligand-gated ion channel (GLIC) using mutagenesis and electrophysiology.

An original potentiating mechanism revealed by the cryoEM structures of the human α7 nicotinic receptor in complex with nanobodies

The paper solves cryo-EM structures of human α7 nicotinic receptor nanobody complexes, revealing E3's mechanism of inducing active or desensitized conformations through a N-linked sugar moiety.

Expression pattern of nicotinic acetylcholine receptor subunit transcripts in neurons and astrocytes in the ventral tegmental area and locus coeruleus

The paper identifies and quantifies nAChR subunit transcript expression in specific neurons and astrocytes in the VTA and LC across age and sex in mice.

The human acetylcholinesterase c-terminal T30 peptide activates neural growth through an alpha 7 nicotinic acetylcholine receptor mTOR pathway

The paper identifies the T30 peptide from AChE as a bioactive molecule that activates the mTOR pathway through 7 nAChR, promoting neural cell growth.

Two residues determine nicotinic acetylcholine receptor requirement for RIC-3

The paper identifies two residues in the ACR-16 N-AChR that determine whether the receptor requires RIC-3 for functional expression in heterologous systems.

Hyperconnectivity of two separate long-range cholinergic systems contributes to the reorganization of the brain functional connectivity during nicotine withdrawal in male mice

The paper investigates how cholinergic systems contribute to changes in brain functional connectivity during nicotine withdrawal in male mice, identifying two distinct long-range cholinergic networks and associated genes.

Prolonged nicotine exposure reduces aversion to the drug in mice by altering nicotinic transmission in the interpeduncular nucleus.

Generation of nanobodies acting as silent and positive allosteric modulators of the α7 nicotinic acetylcholine receptor

This paper describes the generation of nanobodies that act as silent and positive allosteric modulators of the α7 nicotinic acetylcholine receptor, with distinct functional properties.

Organophosphate intoxication in C. elegans reveals a new route to mitigate poisoning through the modulation of determinants responsible for nicotinic acetylcholine receptor function

The paper shows that modulating nicotinic acetylcholine receptor function in C. elegans can mitigate organophosphate poisoning through plasticity-promoting mechanisms.

Isoform-specific nicotinic responses are present in distinct subtypes of prefrontal layer V pyramidal neurons

The paper identifies three isoform-specific nicotinic receptor responses in distinct subtypes of prefrontal layer V pyramidal neurons in mice.

Patient-derived glioblastoma neurosphere cultures differentially express nicotinic acetylcholine receptors depending on ambient choline

The paper shows that patient-derived glioblastoma neurosphere cultures express nicotinic acetylcholine receptors (nAChRs) 1*, 7, and 9, and their expression and function vary with choline levels in the culture environment.

Short-chain mono-carboxylates as negative modulators of allosteric transitions in GLIC, and impact of a pre-β5 strand (Loop {Omega}) double mutation on crotonate, not butyrate effect.

The paper identifies a mutation in the pre-β5 strand of GLIC that changes crotonate from a negative to positive modulator, suggesting its role in coupling ligand binding to pore gating.

Short-chain di-carboxylates as positive allosteric modulators of the pH-dependent pentameric ligand-gated ion channel GLIC: requirement of an intact vestibular pocket

The paper shows short-chain di-carboxylates modulate GLIC activity, with fumarate being the most potent, and reports a Cs+/Na+ permeability ratio for GLIC.

Xanomeline restores endogenous nicotinic acetylcholine receptor signaling in mouse prefrontal cortex

This study shows that xanomeline restores age-related nicotinic signaling deficits in mouse prefrontal cortex by enhancing muscarinic receptor pathways and nicotinic receptor availability.

Cholinergic boutons are distributed along the dendrites and somata of VIP neurons in the inferior colliculus

The paper shows cholinergic boutons contact VIP neurons in the inferior colliculus, influencing their synaptic computations.