C. Wang

SARS-CoV-2 causes human BBB injury and neuroinflammation indirectly in a linked organ chip platform

This study shows SARS-CoV-2 indirectly causes BBB injury and neuroinflammation through systemic inflammation, not direct viral infection, using a linked alveolus-BBB organ chip platform.

A gut commensal niche regulates stable association of a multispecies microbiota

The study identifies a strain-specific bacterial niche in the Drosophila foregut that stabilizes microbiota composition through spatial and competitive interactions.

Synthesis of 4-methylvaleric acid, a precursor of pogostone, involves a 2-isobutylmalate synthase related to 2-isopropylmalate synthase of leucine biosynthesis

The paper identifies 2-isobutylmalate synthase (IBMS) as a novel enzyme related to IPMS that catalyzes the synthesis of 4-methylvaleric acid, a precursor of pogostone.

HIV-1 Vif protein is stabilized by AKT-mediated phosphorylation to enhance APOBEC3G degradation

This study identifies AKT-mediated phosphorylation of HIV-1 Vif at T20 as a mechanism to stabilize Vif and enhance APOBEC3G degradation, revealing a complex interplay between AKT, Vif, and MDM2 in HIV-1 pathogenesis.

MyD88 Mediates Colitis- and RANKL-induced Microfold Cell Differentiation

This study shows MyD88 is essential for M cell differentiation in colitis and RANKL-induced conditions in mice.

Mechanoaccumulation of non-muscle myosin IIB during mitosis requires its translocation activity

This study shows that during mitosis, NMIIB mechanoaccumulation at the cell cortex requires its motor activity, not just actin-binding function, and is mediated by RhoA and ROCK signaling.

Canopy health, but not Candidatus Liberibacter asiaticus Ct values, are correlated with fruit yield in Huanglongbing affected sweet orange trees.

The paper identifies canopy health metrics as better predictors of fruit yield than CLas Ct values in HLB-affected sweet orange trees.

Genome-wide analysis tracks the emergence of intraspecific polyploids in Phragmites australis

This study uses genome-wide analysis to track polyploid emergence in Phragmites australis, identifying multiple lineages and ploidy levels with genomic conflicts.

Two Ubiquitin-Activating Systems Occur in Plants with One Playing a Major Role in Plant Immunity

The paper identifies two ubiquitin-activating systems in plants, showing that one E1 plays a major role in plant immunity by differentially charging ERAD-associated E2s for ER stress tolerance.

Nanomolar, noncovalent antagonism of hedgehog cholesterolysis: exception to the irreversibility rule for protein autoprocessing inhibition.

The paper identifies noncovalent, reversible inhibitors of HhC cholesterolysis, challenging the irreversibility rule for protein autoprocessing inhibition.

Predicting hosts based on early SARS-CoV-2 samples and analyzing later world-wide pandemic in 2020

The paper introduces DeepHoF, a deep learning method to predict viral hosts, and applies it to SARS-CoV-2 to identify potential hosts and analyze host range uniformity during the pandemic.

Bayesian metamodeling of complex biological systems across varying representations

This paper introduces Bayesian metamodeling to integrate diverse models of biological systems, demonstrating its application to glucose-stimulated insulin secretion in pancreatic β-cells.

Diterpenoid Vinigrol activates ATF4/DDIT3-mediated PERK/eIF2 arm of unfolded protein response to drive breast cancer cell death

This study identifies Vinigrol as a broad-spectrum anti-cancer agent that activates the PERK/eIF2 arm of the UPR via ATF4/DDIT3 to induce breast cancer cell death.

Transcriptome profiling of Candidatus Liberibacter asiaticus in citrus and psyllids

This study profiles the transcriptome of Candidatus Liberibacter asiaticus in citrus and psyllids, identifying gene expression patterns and differentially expressed genes between hosts.

Augmenting Neutralization breadth against Diverse HIV-1 by increasing the Ab-Ag interface on V2

This study identifies a lineage of antibodies from infected rhesus macaques that neutralize 54% of HIV-1 strains by expanding the antibody-Env interface around the V2 loop.

Two-dimensional multiplexed assay for rapid and deep SARS-CoV-2 serology profiling and for machine learning prediction of neutralization capacity

This paper introduces a 2D-MBBA assay for SARS-CoV-2 serology profiling and uses machine learning to predict neutralization capacity from antibody profiles.

Untangling Microbiota Diversity and Assembly Patterns in the World's Largest Water Diversion Canal

The paper investigates microbiota dynamics and assembly patterns in a large water diversion canal, finding deterministic processes shape bacterial communities while stochasticity dominates micro-eukaryotic communities.

Spatial and temporal localization of cell wall associated pili in Enterococcus faecalis

This study investigates the spatial and temporal localization of Ebp pili on E. faecalis cell surfaces, finding they are anchored to the cell hemisphere, not at the septum where new cell wall is synthesized.

Structure of Infective Getah Virus at 2.8 A-resolution Determined by Cryo-EM

The paper determines the structure of infective Getah virus at 2.8 Å resolution using cryo-EM, revealing glycosylation, S-acylation sites, and lipid interactions critical for immune evasion and host cell invasion.

Dynamics of glioma-associated microglia and macrophages reveals their divergent roles in the immune response of brain

The paper uses single-cell sequencing to analyze glioma-associated microglia and macrophages, revealing their distinct roles in tumor progression and clinical outcomes.

Wall-associated Receptor Kinase and The Expression Profiles in Wheat Responding to Fungal Stress

This study classifies wheat WAKs and WAKLs, identifies structural features, and shows that TaWAK75 and TaWAK76b are involved in resistance to Bgt.

Comparative phylogenomic analysis reveals evolutionary genomic changes and novel toxin families in endophytic Liberibacter pathogens

This study identifies genomic changes and novel toxins in Liberibacter pathogens through comparative phylogenomic analysis, linking prophage loci and gene gains/losses to pathogenicity.

Analysis of meiosis in Pristionchus pacificus reveals plasticity in homolog pairing and synapsis in the nematode lineage

The paper analyzes meiosis in Pristionchus pacificus, showing that DMC-1 and RAD-51 have distinct roles in homolog pairing and synapsis compared to C. elegans.

Early cross-coronavirus reactive signatures of protective humoral immunity against COVID-19

The paper profiles early humoral immune responses in COVID-19 patients, finding that survivors show rapid SARS-CoV-2-specific immunity linked to pre-existing OC43 immunity, while non-survivors have delayed and blunted responses.

Coil-to-Helix Transition at the Nup358-BicD2 Interface Activates BicD2 for Dynein Recruitment

The paper identifies a Nup358 helix that transitions to an α-helix upon BicD2 binding, facilitating dynein recruitment and processive motility.

Mechanistic Insights of High Temperature-Interfered Meiosis in Autotetraploid Arabidopsis thaliana

This study investigates how high temperatures affect meiosis in autotetraploid Arabidopsis thaliana, revealing that heat stress disrupts chromosome axis stability and meiotic recombination.

Circadian Control of Heparan Sulfate Levels Times Phagocytosis of Amyloid Beta Aggregates

This study shows that circadian rhythms control heparan sulfate levels, which regulate phagocytosis of amyloid-beta aggregates in a mouse model of Alzheimer's disease.

Genome of the estuarine oyster provides insights into climate impact and adaptive plasticity

The paper analyzes the genome of the estuarine oyster to show how climate history and physical forces shape genomic diversity and adaptive plasticity through gene expansion and regulatory selection.

Homo-harringtonine (HHT) - A highly effective drug against coronaviruses and the potential for large-scale clinical applications

The paper identifies Homo-harringtonine (HHT) as a potent antiviral drug against coronaviruses, effective in mouse models and safe in dogs, with potential for large-scale clinical use.

Genome-wide CRISPR activation screen identifies novel receptors for SARS-CoV-2 entry

This study identifies novel SARS-CoV-2 receptors through a CRISPR activation screen, revealing LDLRAD3, TMEM30A, and CLEC4G as functional receptors independent of ACE2.