F. Wang

Hantaan virus replication is promoted via AKT activated mitochondria OXPHOS

This study shows Hantaan virus uses mitochondrial OXPHOS for replication, driven by AKT activation and PNPT phosphorylation.

HMGN5 escorts oncogenic STAT3 signaling by regulating chromatin landscape in tumorigenesis of breast cancer

This study identifies HMGN5 as a novel epigenetic target in breast cancer by showing it promotes tumorigenesis through STAT3-mediated chromatin regulation and suggests siRNA-based therapy.

Histone neutralization in a rat model of acute lung injury induced by double-hit lipopolysaccharide

This study shows that histone neutralization with STC3141 reduces circulating histones, improves oxygenation, and decreases lung edema in a rat model of LPS-induced ALI, similar to dexamethasone.

Molecular mechanisms governing circulating immune cell heterogeneity across different species revealed by single cell sequencing

This study uses single-cell RNA-sequencing to analyze immune cell diversity across 12 species, revealing conserved and divergent molecular mechanisms and cellular interactions.

On the use of facial and neck cooling to improve indoor occupant thermal comfort in warm conditions

This study evaluates two wearable face and neck cooling fans to improve indoor thermal comfort and reduce HVAC energy use in warm conditions.

A pair of transporters controls mitochondrial Zn2+ levels to maintain mitochondrial homeostasis

The paper identifies two transporters that regulate mitochondrial Zn2+ levels in C. elegans, showing their roles in maintaining mitochondrial homeostasis.

Coordinated DNA and Histone Dynamics Drive Accurate Histone H2A.Z Exchange

The paper uses single-molecule FRET to show SWR1 unwraps DNA and exchanges H2A-H2B for H2A.Z-H2B with timed precision.

FOXP4 differentially controls cold-induced beige adipocyte differentiation and thermogenesis

This study identifies FOXP4 as a regulator of beige adipocyte differentiation and thermogenesis, showing it suppresses thermogenic potential in preadipocytes but enhances it in mature adipocytes.

HOXB13 suppresses de novo lipogenesis through HDAC3-mediated epigenetic reprogramming

This study identifies HOXB13's AR-independent role in suppressing lipogenesis via HDAC3-mediated epigenetic repression, linking its loss to metastatic prostate cancer progression.

Engineered neuron-targeting, placental mesenchymal stromal cell-derived extracellular vesicles for in utero treatment of myelomeningocele

This paper engineers neuron-targeting extracellular vesicles for in utero treatment of myelomeningocele, showing improved neuroprotection and reduced apoptosis in a rodent model.

α-/γ-Taxilin are required for centriolar subdistal appendage assembly and microtubule organization

This study identifies α-taxilin and γ-taxilin as new components of centriolar subdistal appendages, showing their role in microtubule anchorage and spindle orientation.

Dissecting the roles of Haspin and VRK1 in Histone H3 threonine-3 phosphorylation during mitosis

This study investigates the roles of Haspin and VRK1 in phosphorylating histone H3 during mitosis, finding that VRK1 does not directly phosphorylate H3T3 or H3S10, while Haspin is essential for H3T3ph.

SNR-efficient distortion-free diffusion relaxometry imaging using ACcelerated Echo-train shifted EPTI (ACE-EPTI)

This paper introduces ACE-EPTI, a diffusion MRI technique that improves SNR efficiency and reduces distortion, achieving high-resolution, multi-TE images with 3-shot acquisition.

Non-Invasive Confocal Fluorescence Imaging of Mice Beyond 1700 nm Using Superconducting Nanowire Single-Photon Detectors

This paper develops a non-invasive imaging technique using NIR-IIc light to image deep tissues in mice, achieving imaging depths of ~800 m and visualizing immune structures in lymph nodes.

Pancreatic Brsk2 amplifies parasympathetic signals to promote type 2 diabetes

This study shows Brsk2 amplifies parasympathetic signals to promote type 2 diabetes by enhancing β-cell insulin secretion in obese mice and associates human BRSK2 variants with metabolic disorders.

In Vitro efficacy comparison of linezolid, tedizolid, sutezolid and delpazolid against rapid growing Mycobacteria isolated in Beijing, China

This study compares the in vitro efficacy of four oxazolidinones against rapid-growing Mycobacteria isolates from Beijing, finding tedizolid most effective against M. abscessus and delpazolid against M. fortuitum.

COVID-ONE-humoral immune: The One-stop Database for COVID-19-specific Antibody Responses and Clinical Parameters

The paper introduces a database that compiles antibody responses and clinical data from COVID-19 patients for analysis and visualization.

Cdc14 activates autophagy to regulate spindle pole body dynamics during meiosis

This study identifies Cdc14 as a meiosis-specific autophagy regulator that controls spindle pole body dynamics by dephosphorylating Atg13 and promoting autophagy during anaphase I and II.

Dynamic surveillance of mosquitoes and their viromes in Wuhan during 2020.

This study analyzes mosquito species and viromes in Wuhan, China, from April to October 2020, revealing seasonal changes and stable viruses in Culex mosquitoes.

Single-dose respiratory mucosal delivery of next-generation viral-vectored COVID-19 vaccine provides robust protection against both ancestral and variant strains of SARS-CoV-2

This study evaluates a multivalent Ad-vectored vaccine delivered via respiratory mucosal route, showing robust protection against SARS-CoV-2 and variants in mice.

Heterogeneity in the transcriptional response of the human pathogen Aspergillus fumigatus to the antifungal agent caspofungin

This study investigates transcriptional heterogeneity in Aspergillus fumigatus strains responding to caspofungin, identifying a core response and variable response linked to secondary metabolite biosynthesis and iron homeostasis.

WDR82-binding long non-coding RNA lncEry controls mouse erythroid differentiation and maturation

The paper identifies lncEry, a long non-coding RNA that regulates mouse erythroid differentiation and maturation by interacting with WDR82 to control Klf1 and globin gene transcription.

Isolation and characterization of a Cyprinid herpesvirus strain YZ01 from apparently healthy goldfish after rising water temperature

The paper isolates and characterizes a Cyprinid herpesvirus strain YZ01 from goldfish exposed to elevated water temperatures, showing high genomic similarity to other C genotype strains.

Activating P2Y1 receptors improves function in arteries with repressed autophagy

This study shows that activating P2Y1 receptors enhances arterial function in conditions where endothelial autophagy is suppressed.

The globular C1q receptor is required for epidermal growth factor receptor signaling during Candida albicans infection

This study identifies proteins interacting with EGFR during C. albicans infection and shows that gC1qR is essential for EGFR signaling and immune responses.

Screening of chemical libraries for new antifungal drugs against Aspergillus fumigatus reveals the potential mechanism of action of miltefosine

This study screens 1,127 compounds against Aspergillus fumigatus, identifies miltefosine as fungicidal, and reveals RmiA as a transcription factor regulating sphingolipid biosynthesis involved in miltefosine resistance.

3D Echo Planar Time-resolved Imaging (3D-EPTI) for ultrafast multi-parametric quantitative MRI

This paper introduces 3D-EPTI, a novel MRI technique that enables ultrafast multi-parametric quantitative imaging with high resolution and efficiency.

A statistical test for clonal exclusivity in tumour evolution

This paper introduces a statistical test, GeneAccord, to identify clonally exclusive gene pairs in tumours and applies it to AML data, finding 6 exclusive and 2 co-occurring pairs.

Structures of the active HER2/HER3 receptor complex reveal dynamics at the dimerization interface induced by binding of a single ligand

This study presents cryo-EM structures of the HER2/HER3 receptor complex bound to NRG1β, revealing conformational dynamics at the dimerization interface and how mutations and therapeutics interact with this interface.

Toxoplasma TgATG9 is critical for autophagy and long-term persistence in tissue cysts

This study shows that TgATG9 is essential for autophagy and long-term survival of Toxoplasma gondii bradyzoites in tissue cysts.