S. Lu

Constitutive G protein coupling profiles of understudied orphan GPCRs

The paper uses BRET to determine G protein coupling profiles of 48 orphan GPCRs without ligands, identifying 48 receptor-G protein pairs, many previously unknown.

A trimeric human angiotensin-converting enzyme 2 as an anti-SARS-CoV-2 agent in vitro

This study creates a trimeric ACE2 variant with high affinity for SARS-CoV-2 spike protein and shows it inhibits viral infection in cell culture.

Structural and immunological identification and antiviral infection experiment of the dominant cytotoxic T lymphocyte epitopes of the oncogenic Marek's disease virus

The paper identifies dominant cytotoxic T lymphocyte epitopes of Marek's disease virus, confirms their immunoprotective effects, and highlights key factors for effective antitumor immunity.

Endothelial SOCS3 maintains homeostasis and promotes survival in endotoxemic mice

This paper shows that endothelial SOCS3 prevents shock-induced organ failure by inhibiting IL-6 signaling and maintaining vascular barrier function.

The immunodominant and neutralization linear epitopes for SARS-CoV-2

This study identifies immunodominant and neutralizing epitopes on SARS-CoV-2 proteins through computational simulation and experimental validation in mice.

An effective, safe and cost-effective cell-based chimeric vaccine against SARS-CoV2

This study develops a cell-based chimeric vaccine against SARS-CoV-2 that induces strong T cell immunity and neutralizing antibodies without toxicity.

Separation and identification of permethylated glycan isomers by reversed phase nanoLC-NSI-MSn

This paper develops an optimized LC-MSn workflow for separating and identifying permethylated glycan isomers without requiring glycan standards or high-resolution mass spectrometers.

The SARS-CoV-2 Nucleocapsid phosphoprotein forms mutually exclusive condensates with RNA and the membrane-associated M protein

This study shows the SARS-CoV-2 N protein forms distinct condensates with RNA and M protein, aiding viral RNA packaging and virion assembly.

Modeling alcoholic liver disease in a human Liver-Chip

This paper develops a human ALD Liver-Chip to model alcohol-induced liver injury, showing it recapitulates FLD markers and enables multimodal profiling of clinically relevant endpoints.

Chloroquine and hydroxychloroquine as ACE2 blockers to inhibit viropexis of 2019-nCoV Spike pseudotyped virus

This study investigates whether chloroquine and hydroxychloroquine inhibit 2019-nCoV infection by blocking ACE2 binding, showing both drugs suppress virus entry into ACE2-expressing cells.

Validation and Performance Comparison of Three SARS-CoV-2 Antibody Assays

This study validates and compares three SARS-CoV-2 antibody assays, finding high sensitivity and specificity with low cross-reactions and interferences.

Comparison of SARS-CoV-2 Indirect and Direct Detection Methods

This paper compares indirect and direct SARS-CoV-2 detection methods, finding that BGI's system is most sensitive but costly, while direct methods are less sensitive but faster and cheaper.

Broad-spectrum antivirals of protoporphyrins inhibit the entry of highly pathogenic emerging viruses

This study identifies a protoporphyrin derivative that inhibits entry of enveloped viruses by targeting viral lipids, showing broad antiviral activity in vitro and in vivo.

Susceptibility of tree shrew to SARS-CoV-2 infection

This study investigates tree shrew susceptibility to SARS-CoV-2 infection and finds that they show mild symptoms and low viral replication, suggesting limited susceptibility.

Resolving an underrepresented circulating tumor cell population in lung cancer enabled by Hexokinase 2 analysis

This study identifies HK2 as a marker for detecting underrepresented CTCs in NSCLC, revealing a distinct subpopulation with unique characteristics.

Comparison of SARS-CoV-2 infections among 3 species of non-human primates

This study compares SARS-CoV-2 infection outcomes in three non-human primate species, finding that M. mulatta is most susceptible, followed by M. fascicularis and C. jacchus.

KMT2D Links TGF-β Signalling to Non-Canonical Activin Pathway and Regulates Pancreatic Cancer Cell Plasticity

This study identifies KMT2D as a tumor suppressor in pancreatic cancer, linking TGF-β signaling to the non-canonical activin A pathway through miR-147b and showing its role in cancer cell plasticity and metastasis.

TDP-43 and HSP70 phase separate into anisotropic, intranuclear liquid spherical annuli

The paper shows acetylation of TDP-43 drives its phase separation into intranuclear spherical annuli with liquid properties, regulated by HSP70 chaperone activity and proteasome function.

Accelerated single cell seeding in relapsed multiple myeloma

This study uses whole genome sequencing to show that relapsed multiple myeloma exhibits accelerated systemic seeding driven by chemotherapy-induced mutations and clonal expansion of single myeloma cells.

Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody

This study shows that the SARS-CoV-specific antibody CR3022 binds strongly to 2019-nCoV RBD with a KD of 6.3 nM, while other antibodies targeting the ACE2 site fail to bind, highlighting the importance of RBD differences for cross-reactivity.

Red blood cell-derived extracellular vesicles mediate intercellular communication in ischemic heart failure

The paper uses a transgenic mouse model to show RBC-derived extracellular vesicles target cardiomyocytes and microglia in ischemic heart failure, with targeted cells showing gene enrichment in proliferation and metabolism.

Beyond a ribosomal RNA methyltransferase, the wider role of MraW in DNA methylation, motility and colonization in Escherichia coli O157:H7

This paper identifies MraW as a DNA methylase in E. coli O157:H7, showing its role in motility, colonization, and virulence through genome-wide methylation and regulation of flagellar genes.

Natural selection on TMPRSS6 associated with the blunted erythropoiesis and improved blood viscosity in Tibetan Pigs

This study identifies a deletion in TMPRSS6 associated with reduced hemoglobin and improved blood viscosity in Tibetan pigs adapted to high altitude.

Systematic Discovery of the Functional Impact of Somatic Genome Alterations in Individual Tumors through Tumor-specific Causal Inference

This paper introduces a tumor-specific causal inference framework to identify causative somatic genome alterations and their impact on molecular phenotypes in individual tumors.

Mono-homologous linear DNA recombination by the non-homologous end-joining pathway as a novel and simple gene inactivation method: a proof of concept study in Dietzia sp. DQ12-45-1b

This paper demonstrates a novel gene inactivation method using NHEJ-mediated mono-homologous linear DNA recombination in Dietzia sp. DQ12-45-1b, showing its potential for broad application in prokaryotes.

Acute and chronic toxicity assessment of benzylpenicillin G residues in heat-treated animal food products

This study assesses the acute and chronic toxicity of benzylpenicillin G residues in heat-treated animal food products using a mouse model, finding reduced LD50 and organ damage at high exposure levels.